Abstract
Three classes of 12,13-epoxytrichothecenes, differing in the number of hydroxy or acetoxy substituents, were implanted or injected into rat brain to establish structure-toxicity relationships. A free 3α-hydroxy group increases toxicity more than 10-fold, when compared to trichothecenes lacking this substituent. The 8α-hydroxy group enhances toxicity about 4-fold.
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References
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Bergmann, F., Yagen, B. Structure-activity relationships for the direct toxic action of trichothecenes on rat brain. Arch Toxicol 63, 155–156 (1989). https://doi.org/10.1007/BF00316439
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DOI: https://doi.org/10.1007/BF00316439