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Neuropathy due to podophyllin intoxication

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Summary

A 22-year-old man developed a severe sensorimotor neuropathy following ingestion of podophyllin, which had been prescribed for genital condylomata. The initial toxic symptoms were vomiting and diarrhoea, followed by peripheral neuropathy. The neuropathy was still present 18 months later. Nerve conduction studies and sural nerve biopsy confirmed the presence of axonal degeneration.

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Authors and Affiliations

  1. Department of Medicine, Cork Regional Hospital, Wilton, Cork, Ireland

    S. O'Mahony, D. O'Riordain & M. Whelton

  2. Neuropathology Laboratory, Pathology Department, Cork Regional Hospital, Wilton, Cork, Ireland

    C. Keohane

  3. Department of Neuropathology, Institute of Neurology and The National Hospital, Queen Square, London, UK

    J. Jacobs

Authors
  1. S. O'Mahony
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  2. C. Keohane
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  3. J. Jacobs
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  4. D. O'Riordain
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  5. M. Whelton
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O'Mahony, S., Keohane, C., Jacobs, J. et al. Neuropathy due to podophyllin intoxication. J Neurol 237, 110–112 (1990). https://doi.org/10.1007/BF00314673

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  • DOI: https://doi.org/10.1007/BF00314673

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