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Abnormal cytoskeletal pathology peculiar to corticobasal degeneration is different from that of Alzheimer's disease or progressive supranuclear palsy

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Abstract

An autopsy case of clinically diagnosed “corticobasal degeneration (CBD)” was investigated. In addition to status spongiosus and neuronal achormasia around the central sulcus, cortical pyramidal neurons and thread-like structures were densely stained by Gallyas stain and tau immunohistochemistry, but apparent fibrillary structures like Alzheimer's disease neurofibrillary tangle were absent. Bodian, methenamine-Bodian, Congo red, thioflavin S, or Bielshowsky stains failed to visualize these structures. They were not stained by immunohistochemical stain with anti-ubiquitin antibody. The widespread cytoskeletal pathology, which is distinct from that in Alzheimer's disease or progressive supranuclear palsy, is suggestive of CBD.

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Authors and Affiliations

  1. Department of Neurology, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, 113, Bunkyo-ku, Tokyo, Japan

    Toshiki Uchihara, Kazuko Mitani & Masahito Yamada

  2. Department of Neurology, Kakeyu Rehabilitation Center Hospital, 1308 Nishiuchi, Maruko-machi, Chiisagata-gun, 386-03, Nagano, Japan

    Kazuko Mitani

  3. Department of Psychiatry, Asai Hospital, 38 Yatoku, 283, Tougane-City, Chiba, Japan

    Hiroshi Mori

  4. Department of Neuropathology, Tokyo Institute of Psychiatry, 2-1-8 Kamikitazawa, 156, Setagaya-ku, Tokyo, Japan

    Toshiki Uchihara, Hiromi Kondo & Kenji Ikeda

Authors
  1. Toshiki Uchihara
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  2. Kazuko Mitani
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  3. Hiroshi Mori
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  4. Hiromi Kondo
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  5. Masahito Yamada
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  6. Kenji Ikeda
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Uchihara, T., Mitani, K., Mori, H. et al. Abnormal cytoskeletal pathology peculiar to corticobasal degeneration is different from that of Alzheimer's disease or progressive supranuclear palsy. Acta Neuropathol 88, 379–383 (1994). https://doi.org/10.1007/BF00310383

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  • DOI: https://doi.org/10.1007/BF00310383

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