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Distribution of two forms of somatostatin in the brain, anterior intestine, and pancreas of adult lampreys (Petromyzon marinus)

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Summary

The distribution of two major immunoreactive forms of somatostatin, somatostatin-14 and somatostatin-34, within the brain, pancreas and intestine of adult lampreys, Petromyzon marinus, was identified using antisera raised against these peptides. Immunostaining of the brain is similar in juveniles and upstream migrants, and somatostatin-14 is the major somatostatin form demonstrated. A few somatostatin-34-containing cells are localized within the olfactory bulbs, thalamus and hypothalamus, but cells immunoreactive to anti-somatostatin-34 in the hypothalamus and thalamus do not co-localize somatostatin-14. Immunostaining of pinealocytes within the pineal pellucida with anti-somatostatin-14 may infer a novel function for this structure. Somatostatin-14 and somatostatin-34 are co-localized within D-cells of the cranial pancreas and caudal pancreas of juveniles and upstream migrants. Numerous somatostatin-34-immunoreactive cells are distributed within the epithelial mucosa of the anterior intestine but not all of these cells cross-react with anti-somatostatin-14. It appears that somatostatin-34 is the major somatostatin in the pancreo-gastrointestinal system of adult lampreys.

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Authors and Affiliations

  1. Department of Zoology and Scarborough Campus, University of Toronto, West Hill, Ontario, Canada

    Richard Cheung & John H. Youson

  2. School of Fisheries, University of Washington, Seattle, Washington, USA

    Erika M. Plisetskaya

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  1. Richard Cheung
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  2. Erika M. Plisetskaya
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  3. John H. Youson
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Cheung, R., Plisetskaya, E.M. & Youson, J.H. Distribution of two forms of somatostatin in the brain, anterior intestine, and pancreas of adult lampreys (Petromyzon marinus). Cell Tissue Res 262, 283–292 (1990). https://doi.org/10.1007/BF00309883

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