Skip to main content
Log in

Gliofibroma: immunohistochemical analysis

  • Case Reports
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Summary

A case of gliofibroma occurring in an adult patient as a large circumscribed supratentorial tumor is reported. The bimorphic pattern was substantiated and further analyzed by immunohistochemistry. Some evidence in favor of collagen production by mesenchymal and/or inflammatory cells leading to a progressive fibrous replacement of the glial cells in this particular tumor type is presented.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Bonnin JM, Warner JC, Turner MS (1990) Cystic gliofibroma of the fourth ventricle (abstract). J Neuropathol Exp Neurol 49:261

    Google Scholar 

  2. Budka H, Sunder-Plassmann M (1980) Benign mixed glialmesenchymal tumour (“glio-fibroma”) of the spinal cord. Acta Neurochir 55:141–145

    Google Scholar 

  3. Friede RL (1978) Gliofibroma — A peculiar neoplasia of collagen forming glia-like cells. J Neuropathol Exp Neurol 37:300–313

    Google Scholar 

  4. Ghadially FN (1988) Ultrastructural pathology of the cell and matrix, 3rd edn, vol 2. Butterworths, London, pp 1232–1233

    Google Scholar 

  5. Grant JW (1983) Histiocytic origin of the sarcomatous elements in gliosarcomas (abstr). Neuropathol Appl Neurobiol 9:335

    Google Scholar 

  6. Grant JW, Steart PV, Aguzzi A, Jones DB, Gallagher PJ (1989) Gliosarcoma: an immunohistochemical study. Acta Neuropathol 79:305–309

    Google Scholar 

  7. Ho K-L (1990) Histogenesis of sarcomatous component of the gliosarcoma: an ultrastructural study. Acta Neuropathol 81:178–188

    Google Scholar 

  8. Iglesias JR, Richardson EP Jr, Collia F, Santos A, Garcia MC, Redondo C (1984) Prenatal intramedullary gliofibroma. Acta Neuropathol (Berl) 62:230–234

    Google Scholar 

  9. Kepes JJ, Rubinstein LJ, Eng LF (1979) Pleomorphic xanthoastrocytoma: a distinctive meningocerebral glioma of young subjects with relatively favorable prognosis. Cancer 44:1839–1852

    Google Scholar 

  10. McKeever PE, Fligiel SEG, Varani J, Hudson JL, Smith D, Castle R, McCoy JP (1986) Products of cells cultured from gliomas. IV. Extracellular matrix proteins of gliomas. Int J Cancer 45:471–478

    Google Scholar 

  11. Kochi N, Budka H (1987) Contribution of histiocytic cells to sarcomatous development of the gliosarcoma: an immunohistochemical study. Acta Neuropathol (Berl) 73:124–130

    Google Scholar 

  12. Liesi P, Kaakkola S, Dahl D, Vaheri A (1984) Laminin is induced in astrocytes of adult brain by injury. EMBO J 3:683–686

    Google Scholar 

  13. Meis JM, Ho K-L, Nelson JS (1990) Gliosarcoma: a histologic and immunohistochemical reaffirmation. Mod Pathol 3:19–24

    Google Scholar 

  14. Ng THK, Fung CF, Ma LT (1990) The pathological spectrum of desmoplastic infantile gangliogliomas. Histopathology 16:235–241

    Google Scholar 

  15. Paulus W, Roggendorf W, Schuppan D (1988) Immunohistochemical investigation of collagen subtypes in human glioblastomas. Virchows Arch [A] 413:325–332

    Google Scholar 

  16. Reifenberger G (1991) Immunhistochemie der Tumoren des Nervensystems. Springer, Berlin Heidelberg New York, p 153

    Google Scholar 

  17. Reinhardt V, Nahser HCh (1984) Gliofibroma originating from temporoparietal hamartoma-like lesions. Clin Neuropathol 3:131–138

    Google Scholar 

  18. Rushing EJ, Rorke LB, Sutton L (1991) Gliofibromas and desmoplastic cerebral astrocytoma of infancy — same entity or separate lesions (abstract). Neuropathol Appl Neurobiol (in press)

  19. Russell DS, Rubinstein LJ (1989) Pathology of tumours of the nervous system, 5th edn. Arnold, London Melbourne Auckland, pp 233–237

    Google Scholar 

  20. Taratuto AL, Monges J, Lylyk P, Leiguarda R (1984) Superficial cerebral astrocytoma attached to dura. Cancer 54:2505–2512

    Google Scholar 

  21. VandenBerg SR, May EE, Rubinstein LJ, Herman MM, Perentes E, Vinores SA, Collins VP, Park TS (1987) Desmoplastic supratentorial neuroepithelial tumors of infancy with divergent differentiation potential (“desmoplastic infantile gangliogliomas”). Report on 11 cases of a distinctive embryonal tumor with favorable prognosis. J Neurosurg 66:58–71

    Google Scholar 

  22. Zülch KJ (1979) Histological typing of tumours of the central nervous system. International histological classification of tumours. WHO, Geneva

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schober, R., Bayindir, C., Canbolat, A. et al. Gliofibroma: immunohistochemical analysis. Acta Neuropathol 83, 207–210 (1992). https://doi.org/10.1007/BF00308481

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00308481

Key words

Navigation