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The cerebellar corticonuclear and nucleocortical projections in the cat as studied with anterograde and retrograde transport of horseradish peroxidase

III. The anterior lobe

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Summary

The cerebellar corticonuclear and nucleocortical connections of the anterior lobe were studied in the cat by means of anterograde and retrograde transport of HRP.

Previous experimental studies have given evidence that the cortex of the anterior lobe can be subdivided in a mediolateral direction into seven longitudinal zones: A, B, C1, C2, C3, D1 and D2. An analysis of the present material shows that the Purkinje axons from each cortical zone have their own terminal region within the cerebellar nuclei, and that these areas correspond to those receiving terminal corticonuclear fibres from the same zones in other parts of the cerebellum (Dietrichs and Walberg 1979, 1980). The terminal fields are the rostral part of the fastigial nucleus (the nuclear A zone), the medial nucleus interpositus anterior (the nuclear B zone), the ventromedial nucleus interpositus posterior (the nuclear C1 zone), the dorsolateral nucleus interpositus posterior (the nuclear C2 zone), the lateral nucleus interpositus anterior and the medial part of the transition area between the dentate nucleus and nucleus interpositus anterior (the nuclear C3 zone), the lateral part of this transition area and the medial dentate nucleus (the nuclear D1 zone) and the lateral part of the dentate nucleus (the nuclear D2 zone). The nuclear zones have no sharp borders. The seven main terminal fields are connected by areas where scanty terminal fibres occur, indicatin that the Purkinje axons from each folium of the anterior lobe from medial to lateral terminate along a continuous band which loops through the cerebellar nuclei.

With few exceptions the nucleocortical projection shows the same zonal arrangement as the corticonuclear, but there is in addition a weak nucleocortical connection to the anterior lobe from the middle and caudal parts of the fastigial nucleus.

These and other findings are discussed with reference to previous studies on the corticonuclear and nucleocortical projections, and some comments are made concerning the zonal subdivision of the anterior lobe.

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References

  • Anderson G, Oscarsson O (1978) Climbing fibre microzones in cerebellar vermis and their projection to different groups of cells in the lateral vestibular nucleus. Exp Brain Res 32:565–579

    Google Scholar 

  • Armstrong DM, Schild RF (1978a) An investigation of the cerebellar corticonuclear projections in the rat using an autoradiographic tracing method. I. Projections from the vermis. Brain Res 141:1–19

    Google Scholar 

  • Armstrong DM, Schild RF (1978b) An investigation of the cerebellar corticonuclear projection in the rat using an autoradiographic tracing method. II. Projections from the hemisphere. Brain Res 141:235–249

    Google Scholar 

  • Bishop GA, McCrea RA, Lighthall JW, Kitai ST (1979) An HRP and autoradiographic study of the projection from the cerebellar cortex to the nucleus interpositus anterior and nucleus interpositus posterior of the cat. J Comp Neurol 185:735–756

    Google Scholar 

  • Brodal A, Courville J (1973) Cerebellar corticonuclear projections in the cat: Crus II. An experimental study with silver methods. Brain Res 50:1–23

    Google Scholar 

  • Brodal A, Walberg F (1977) The olivocerebellar projection in the cat studied with the method of retrograde axonal transport of horseradish peroxidase. IV. The projection to the anterior loge. J Comp Neurol 172:85–108

    Google Scholar 

  • Brodal A, Kawamura K (1980) Olivocerebellar projection. A review. Adv Anat Embryol Cell Biol 64:1–40

    Google Scholar 

  • Brodal A, Walberg F, Hoddevik GH (1975) The olivocerebellar projection in the cat studied with the method of retrograde axonal transport of horseradish peroxidase. I. The projection to the paramedian lobule. J Comp Neurol 164:449–470

    Google Scholar 

  • Brodal A, Walberg F, Berkley KJ, Pelt A (1980) Anatomical demonstration of branching olivocerebellar fibres by means of a double retrograde labelling technique. Neuroscience 5:2193–2202

    Google Scholar 

  • Brodal P, Walberg F (1977) The pontine projection to the cerebellar anterior lobe. An experimental study in the cat with retrograde transport of horseradish peroxidase. Exp Brain Res 29:233–248

    Google Scholar 

  • Carrea RME, Reissig M, Mettler FA (1947) The climbing fibers of the simian and feline cerebellum Experimental inquiry into their origin by lesion of the inferior olives and deep cerebellar nuclei. J Comp Neurol 87:321–365

    Google Scholar 

  • Cohen D, Chambers WW, Sprague JM (1958) Experimental study of the efferent projections from the cerebellar nuclei to the brainstem of the cat. J Comp Neurol 109:233–259

    Google Scholar 

  • Courville J, Brodal A (1966) Rubro-cerebellar connections in the cat: An experimental study with silver impregnation methods. J Comp Neurol 126:471–486

    Google Scholar 

  • Courville J, Diakiw N (1976) Cerebellar corticonuclear projection in the cat. The vermis of the anterior and posterior lobes. Brain Res 110:1–20

    Google Scholar 

  • Courville J, Faraco-Cantin F (1980) Topography of the olivocerebellar projection. An experimental study in the cat with an autoradiographic tracing method. In: J Courville, C de Montigny, Y Lamarc (eds) The inferior olivary nucleus: Anatomy and physiology. Raven Press, New York

    Google Scholar 

  • Courville J, Diakiw N, Brodal A (1973) Cerebellar corticonuclear projection in the cat. The paramedian lobule. An experimental study with silver methods. Brain Res 50:25–45

    Google Scholar 

  • Courville J, Augustine JR, Martel P (1977) Projections from the inferior olive to the cerebellar nuclei in the cat demonstrated by retrograde transport of horseradish peroxidase. Brain Res 130:405–419

    Google Scholar 

  • Dietrichs E, Walberg F (1979) The cerebellar corticonuclear and nucleocortical projections in the cat as studied with anterograde and retrograde transport of horseradish peroxidase. I. The paramedian lobule. Anat Embryol 158:13–39

    Google Scholar 

  • Dietrichs E, Walberg F (1980) The cerebellar corticonuclear and nucleocortical projections in the cat as studied with anterograde and retrograde transport of horseradish peroxidase. II. Lobulus simplex, crus I and II. Anat Embryl 161:83–103

    Google Scholar 

  • Dietrichs E, Walberg F (1981) The cerebellar nucleo-olivary projection in the cat. Anat Embryol in press

  • Dietrichs E, Walberg F, Nordby T (1981) On retro- and anterograde transport of horseradish peroxidase in the pontocerebellar fibers as studied with the Mesulam TMB technique. Brain Res 204:179–183

    Google Scholar 

  • Eager RP (1963) Efferent corticonuclear pathways in the cerebellum of the cat. J Comp Neurol 120:81–104

    Google Scholar 

  • Ekerot C-F, Larson B (1979a) The dorsal spino-olivocerebellar system in the cat. I. Functional organization and termination in the anterior lobe. Exp Brain Res 36:201–217

    Google Scholar 

  • Ekerot C-F, Larson B (1979b) The dorsal spino-olivocerebellar system in the cat. II. Somatotopical organization. Exp Brain Res 36:219–232

    Google Scholar 

  • Ekerot C-F, Larson B (1980) Termination in overlapping sagittal zones in cerebellar anterior lobe of mossy and climbing fiber paths activated from dorsal funiculus. Exp Brain Res 38:163–172

    Google Scholar 

  • Gould BB (1977) Topographic organization of the cerebellar nucleo-cortical projection in the cat. Anat Rec 187:592

    Google Scholar 

  • Gould BB (1979) The organization of afferents to the cerebellar cortex in the cat: Projection from the deep cerebellar nuclei. J Comp Neurol 184:27–42

    Google Scholar 

  • Gould BB, Graybiel A (1976) Afferents to the cerebellar cortex in the cat: evidence for an intrinsic pathway leading from the deep nuclei to the cortex. Brain Res 110:601–611

    Google Scholar 

  • Graham RC, Karnovsky MJ (1966) The early stages of absorption of injected horseradish peroxidase in the proximal tubule of mouse kidney: Ultrastuctural cytochemistry by a new technique. J Histochem Cytochem 14:291–302

    Google Scholar 

  • Groenewegen HJ, Voogd J (1977) The parasagittal zonation within the olivocerebellar projection. I. Climbing fiber distribution in the vermis of the cat cerebellum. J Comp Neurol 174:417–488

    Google Scholar 

  • Groenewegen HJ, Voogd J, Freedman SL (1979) The parasagittal zonation within the olivocerebellar projection. II. Climbing fiber distribution in the intermediate and hemispheric parts of cat cerebellum. J Comp Neurol 183:551–602

    Google Scholar 

  • Haines DE (1976) Cerebellar corticonuclear and corticovestibular fibers of the anterior lobe vermis in a prosimian primate, Galago senegalensis. J Comp Neurol 170:67–96

    Google Scholar 

  • Haines DE (1978) Cerebellar corticonuclear-nucleocortical topography: A study of the tree shrew, Tupaia, paraflocculus. Anat Rec 190:411

    Google Scholar 

  • Haines DE, Whitworth RH (1978) Cerebellar cortical efferent fibers of the paraflocculus of tree shrew, Tupaia glis. J Comp Neurol 182:137–150

    Google Scholar 

  • Haines DE, Pearson JC (1979) Cerebellar corticonuclear-nucleocortical topography: A study of the tree shrew, Tupaia, paraflocculus. J Comp Neurol 187:745–758

    Google Scholar 

  • Haines DE, Rubertone JA (1979) Cerebellar corticonuclear fibers of the dorsal culminate lobule (anterior lobe-lobule V) in a prosimian primate, Galago senegalensis. J Comp Neurol 186:321–342

    Google Scholar 

  • Haines DE, Patrick GW (1980) Cerebellar cortical efferent fibers of the dorsal culminate lobule (anterior lobe-lobule V) of the squirrel monkey, Saimiri sciureus. Soc Neuroscience Abstr 6:512

    Google Scholar 

  • Itaya SK, Williams TH, Engel EL (1978) Anterograde transport of horseradish peroxidase enhanced by poly-L-ornithine. Brain Res 150:170–176

    Google Scholar 

  • Jansen J, Brodal A (1940) Experimental studies on the intrinsic fibers of the cerebellum. II. The corticonuclear projection. J Comp Neurol 73:267–321

    Google Scholar 

  • Jansen J, Brodal A (1942) Experimental studies on the intrinsic fibers of the cerebellum. III. The corticonuclear projection in the rabbit and the monkey. Avh Norske Vid-Akad: I Mat Nat K1 3:1–50

    Google Scholar 

  • Kitai ST, McCrea RA, Prutin RJ, Bishop GA (1977) Electrophysiological and horseradish peroxidase studies of precerebellar afferents to the nucleus interpositus anterior. I. Climbing fiber system. Brain Res 122:197–214

    Google Scholar 

  • Korneliussen HK (1967) Cerebellar corticogenesis in Cetacea, with special reference to regional variations. J Hirnforsch 9:151–185

    Google Scholar 

  • Korneliussen HK (1968) On the ontogenetic development of the cerebellum (nuclei, fissures, and cortex) of the rat, with special reference to regional variations in corticogenesis. J Hirnforsch 10:379–412

    Google Scholar 

  • Larsell O (1970) The comparative anatomy and histology of the cerebellum from monotremes through apes (J Jansen, ed) The University of Minnesota Press, Minneapolis

    Google Scholar 

  • Mesulam M-M (1978) Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction-product with superior sensitivity for visualizing neural afferents and efferents. J Histochem Cytochem 26:106–117

    Google Scholar 

  • Mesulam M-M, Rosene D (1979) Sensitivity in horseradish peroxidase neurohistochemistry: A comparative and quantitative study of nine methods. J Histochem Cytochem 27:763–773

    Google Scholar 

  • Oscarsson O (1979) Functional units of the cerebellum — sagittal zones and microzones. Trends in Neurosciences 2:143–145

    Google Scholar 

  • Oscarsson O (1980) Functional organization of olivary projection to the cerebellar anterior lobe. In: J Courville, C de Montigny, Y Lamarc (eds) The inferior olivary nucleus: Anatomy and physiology. Raven Press, New York

    Google Scholar 

  • Satrulee P, Culberson JL, Haines DE (1980) The organization of cerebellar corticonuclear fibers in opossum: Evidence of zones in anterior lobe. Soc Neuroscience Abstr 6:471

    Google Scholar 

  • Tolbert DL, Bantli H (1979) An HRP and autoradiographic study of cerebellar corticonuclear-nucleocortical reciprocity in the monkey. Exp Brain Res 36:563–571

    Google Scholar 

  • Tolbert DL, Bantli H, Bloedel JR (1976) Anatomical and physiological evidence for a cerebellar nucleo-cortical projection in the cat. Neuroscience 1:205–217

    Google Scholar 

  • Tolbert DL, Bantli H, Bloedel JR (1978) Organizational features of the cat and monkey cerebellar nucleocortical projection. J Comp Neurol 182:39–56

    Google Scholar 

  • Vachananda B (1959) The major spinal afferent systems to the cerebellum and the cerebellar corticonuclear connection in Macaca mulatta. J Comp Neurol 112:303–353

    Google Scholar 

  • van Rossum J (1969) Corticonuclear and corticovestibular projections of the cerebellum: an experimental investigation of the anterior lobe, simple lobule and the caudal vermis in the rabbit. Thesis. Van Gorcum, Assen

  • Voogd J (1964) The cerebellum of the cat. Structure and fibre connexions. Thesis. Van Gorcum, Assen

  • Voogd J (1969) The importance of fiber connections in the comparative anatomy of the mammalian cerebellum. In: R Llinás (ed) Neurobiology of cerebellar evolution and development. Amer med Ass, Chicago

    Google Scholar 

  • Voogd J, Bigaré F (1980) Topographical distribution of olivary and corticonuclear fibers in the cerebellum: A review. In: J Courville, C de Montingy, Y Larmarc (eds) The inferior olivary nucleus: Anatomy and physiology. Raven Press, New York

    Google Scholar 

  • Walberg F, Jansen J (1964) Cerebellar corticonuclear projection studied experimentally with silver impregnation methods. J Hirnforsch 6:338–354

    Google Scholar 

  • Walberg F, Nordby T, Dietrichs E (1980) A note on the anterograde transport of horseradish peroxidase within the olivocerebellar fibres. Exp Brain Res 40:233–236

    Google Scholar 

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  1. Anatomical Institute, University of Oslo, Karl Johansgt. 47, Oslo 1, Norway

    Espen Dietrichs

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Dietrichs, E. The cerebellar corticonuclear and nucleocortical projections in the cat as studied with anterograde and retrograde transport of horseradish peroxidase. Anat Embryol 162, 223–247 (1981). https://doi.org/10.1007/BF00306494

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