Abstract
The adenylyl cyclases (AC) act as second messengers in regulatory processes in the central nervous system. They might be involved in the pathophysiology of diseases, but their biological function is unknown, except for AC type I, which has been implicated in learning and memory. We previously mapped the gene encoding AC I to human Chromosome (Chr) 7p12. In this study we report the mapping of the adenylyl cyclase genes type I–VI to mouse chromosomes by fluorescence in situ hybridization (FISH): Adcy1 to Chr 11A2, Adcy2 to 13C1, Adcy3 to 12A-B, Adcy4 to 14D3, Adcy5 to 16B5, and Adcy6 to 15F. We also confirmed previously reported mapping results of the corresponding human loci ADCY2, ADCY3, ADCY5, and ADCY6 to human chromosomes and, in addition, determined the chromosomal location of ADCY4 to human Chr 14q11.2. The mapping data confirm known areas of conservation between mouse and human chromosomes.
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Bakalyar, H.A., Reed, R.R. (1990). Identification of a specialized adenylyl cyclase that may mediate odorant detection. Science 250, 1403–1406.
Cali, J.J., Zwaagstra, J.C., Mons, N., Cooper, D.M.F., Krupinski, J. (1994). Type VIII adenylyl cyclase, a Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain. J. Biol. Chem. 269, 12190–12195.
Choi, E-J., Xia, Z., Villacres, E.C., Storm, D.R. (1993). The regulatory deversity of the mammalian adenylyl cyclases. Curr. Opin. Cell Biol. 5, 269–273.
Copeland, N.G., Jenkins, N.A., Gilbert, D.J., Eppig, J.T., Maltais, L.J., Miller, J.C., Dietrich, W.F., Weaver, A., Lincoln S.E., Steen, R.G., Stein, L.D., Nadeau, J.H., Landers, E.S. (1993). A genetic linkage map of the mouse: current applications and future prospects. Science 262, 57–66.
Edelhoff, S., Ayer, D.E., Zervos, A.S., Steingrimsson, E., Jenkins, N.A., Copeland, N.G., Eisenman, R.N., Brent, R., Disteche, C.M. (1994). Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19. Oncogene 9, 665–668.
Feinstein, P.G., Schrader, K.A., Bakalyar, H.A., Tang, W.-J., Krupinski, J., Gilman, A.G., Reed, R.R. (1991). Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Proc. Natl. Acad. Sci. USA 88, 10173–10177.
Furuyama, T., Inagaki, S., Takagi, H. (1993). Distribution of type II adenylyl cyclase rRNA in the rat brain. Mol. Brain Res. 19, 165–170.
Gao, B., Gilman, A.G. (1991). Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proc. Natl. Acad. Sci. USA 88, 10178–10182.
Green, M.C. (1989). Catalog of mutant genes and polymorphic loci. In Genetic Variants and Strains of the Laboratory Mouse 2nd ed., M.F. Lyon, A.G. Searle, eds. (Oxford, New York, Tokyo: Oxford University Press), pp 12–404.
Haber, N., Stengel, D., Defer, N., Roeckel, N., Mattei, M.-G., Hanoune, J. (1994). Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI. Hum. Genet. 94, 69–73.
Ishikawa, Y., Katsushika, S., Chen, L., Halnon, N.J., Kawabe, J.-i., Homcy, C.J. (1992). Isolation and characterization of a novel cardiac adenylylcyclase cDNA. J. Biol. Chem. 267, 13553–13557.
Iyengar, R. (1993). Molecular and functional diversity of mammalian Gs-stimulated adenylyl cyclases. FASEB J. 7, 768–775.
Katsushika, S., Chen, L., Kawabe, J.-i., Nilakantan, R., Halnon, N.J., Homcy, C.J., Ishikawa, Y. (1992). Cloning and characterization of a sixth adenylyl cyclase isoform: types V and VI constitute a subgroup within the mammalian adenylyl cyclase family. Proc. Natl. Acad. Sci. USA 89, 8774–8778.
Kosik, K.S., Orecchio, L.D., Bruns, G.A., Benowitz, L.I., MacDonald, G.P., Cox, D.R., Neve, R.L. (1988). Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human. Neuron 1, 127–132.
Krupinski, J., Lehman, T.C., Frankenfield, C.D., Zwaagstra, M.C., Watson, P.A. (1992). Molecular diversity in the adenylylcyclase family. Evidence for eight forms of the enzyme and cloning of type VI. J. Biol. Chem. 267, 24858–24862.
Stengel, D., Parma, J., Gannage, M.-H., Roeckel, N., Mattei, M.-G., Barouki, R., Hanoune, J. (1992). Different chromosomal localization of two adenylyl cyclase genes expressed in human brain. Hum. Genet. 90, 126–130.
Villacres, E.C., Xia, Z., Bookbinder, L.H., Edelhoff, S., Disteche, C.M., Storm, D.R. (1993). Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase. Genomics 16, 473–478.
Wu, Z.-L., Thomas, S.A., Villacres, E.C., Xia, Z., Simmons, M.L., Chavkin, C., Palmiter, R.D., and Storm, D.R. (1995). Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice. Proc. Natl. Acad. Sci. USA (in press)
Xia, Z., Refsdal, C.D.R., Merchant, K.M., Dorsa, D.M., Storm, D.R. (1991). Patterns for the distribution of mRNA for the calmodulin-sensitive adenylyl cyclase in rat brain: expression in areas associated with learning and memory. Neuron 6, 431–443.
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Edelhoff, S., Villacres, E.C., Storm, D.R. et al. Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse. Mammalian Genome 6, 111–113 (1995). https://doi.org/10.1007/BF00303253
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DOI: https://doi.org/10.1007/BF00303253