Abstract
The pharmacokinetics of a cholinesterase reactivating oxime, 2-PAM, was comparatively studied in healthy volunteers and in persons suffering from poisoning by organophosphorus insecticides. The elevation of plasma concentrations of the oxime and prolongation of its “effective half-life” were noticed in poisoned individuals. These changes were attributed to the disturbed general hemodynamics and reduced renal blood flow in organophosphorus intoxication rather than to the direct renal toxicity of anticholinesterases.
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References
Chursin IG, Shevtsov IP, Rybalko VM, Samulevich MK (1980) Change in the general hemodynamics and renal blood flow in acute poisoning by organophosphorus compounds (in Russian). Voen Med Žur 2: 63–64
Clement JG, Simons KJ, Briggs CJ (1988) Effect of poisoning by soman (pynacolyl methylphosphonofluoridate) on the serum half-life of the cholinesterase reactivator HI-6 in mice. Biopharm Drug Dispos 9: 177–186
Glick D (1971) Determination of activity of cholinesterases. In: Glick D (ed) Methods of biochemical analysis. Interscience Publishers, New York, pp 235–242
Green MD, Jones DE, Hilmas DE (1985) Sarin intoxication elevates plasma pralidoxime. Toxicol Lett 28: 17–21
Hettwer H (1975a) Über Veränderungen an der Ultrastructur der Rattenniere nach Phosphorsäureestervergiftungen. Acta Histochem 52: 165–210
Hettwer H (1975b) Histochemische Untersuchungen an Leber und Niere der Ratte nach Phosphorsäureestervergiftungen. Acta Histochem 52: 239–252
Jager BV, Stagg GN, Green N, Jager L (1958) Studies on distribution and disappearance of pyridine-2-aldoxime methiodide (PAM) and of diacetyl monoxime (DAM) in man and experimental animals. Bull John Hopkins Hosp 102: 225–234
Jeevarathinam K, Ghosh AK, Srinivasan A, Das Gupta S (1988) Pharmacokinetics of pralidoxime chloride and its correlation to therapeutic efficacy against diisopropyl fluorophosphate intoxication in rats. Pharmazie 43: 114–115
Kepner LA, Wolthuis OL (1978) A comparison of the oximes HS-6 and HI-6 in the therapy of soman intoxication in rodents. Eur J Pharmacol 48: 377–382
Maksimović M, Vojvodić V (1969) Selection of the method for determination of oxime content in biological material (in Serbocroatian, with Summary in English). Arch Hig rada Toksikol 20: 173–176
Ritschel WA (1984) Graphic approach to clinical pharmacokinetics. JR Prous Publishers, Barcelona, pp 36–41
Schoene K, Konig A, Oldiges H, Krugel M (1988) Pharmacokinetics and efficacies of obidoxime and atropine in paraoxon poisoning. Arch Toxicol 61: 387–391
Sidell FR, Groff WA (1971) Intramuscular and intravenous administration of small doses of 2-pyridinium aldoxime methochloride to man. J Pharm Sci 60: 1224–1228
Sundwall A (1961) Minimum concentrations of N-methylpyridinium-2-aldoxime methane sulphonate (P29) which reverse neuromuscular block. Biochem Pharmacol 8: 413–417
Swartz RD, Sidell FR (1974) Renal tubular secretion of pralidoxime in man. Proc Soc Exp Biol Med 146: 419–424
Wolthuis OL, Clason-Van der Wiel HJ, Visser RP (1976) The dependence of the blood level of the oxime HS-6 on the severity of organophosphate poisoning. Eur J Pharmacol 39: 417–421
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Jovanović, D. Pharmacokinetics of pralidoxime chloride. Arch Toxicol 63, 416–418 (1989). https://doi.org/10.1007/BF00303133
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DOI: https://doi.org/10.1007/BF00303133