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A linkage map of mouse Chromosome 1 using an interspecific cross segregating for the gld autoimmunity mutation

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Abstract

An interspecific backross was used to define a high resolution linkage map of mouse Chromosome (Chr) 1 and to analyze the segregation of the generalized lymphoproliferative disease (gld) mutation. Mice homozygous for gld have multiple features of autoimmune disease. Analysis of up to 428 progeny from the backcross [(C3H/HeJ-gld x Mus spretus)F1 x C3H/HeJ-gld] established a map that spans 77.6 cM and includes 56 markers distributed over 34 ordered genetic loci. The gld mutation was mapped to a less than 1 cM segment on distal mouse Chr 1 using 357 gld phenotype-positive backcross mice. A second backcross, between the laboratory strains C57BL/6J and SWR/J, was examined to compare recombination frequency between selected markers on mouse Chr 1. Significant differences in crossover frequency were demonstrated between the interspecific backcross and the inbred laboratory cross for the entire interval studied. Sex difference in meiotic crossover frequency was also significant in the laboratory mouse cross. Two linkage groups known to be conserved between segments of mouse Chr 1 and the long arm of human Chrs 1 and 2 where further defined and a new conserved linkage group was identified that includes markers of distal mouse Chr 1 and human Chr 1, bands q32 to q42.

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Authors and Affiliations

  1. Department of Medicien and Department of Microbiogy, Duke University, 27710, Durham, North Carolina, USA

    Mark L. Watson, Rebecca J. Oakey, Thad A. Howard, Julie M. Rochelle & Michael F. Seldin

  2. Department of Biochemistry and Kaplan Cancer Center, New York University Medical Center, 10016, New York, New York, USA

    Peter D'Eustachio

  3. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, 20892, Bethesda, Maryland, USA

    Beverly A. Mock

  4. Cellular Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 20892, Bethesda, Maryland, USA

    Alfred D. Steinberg

  5. Laboratory of Immunopathology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 20892, Bethesda, Maryland, USA

    Herbert C. Morse III

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  1. Mark L. Watson
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  2. Peter D'Eustachio
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  3. Beverly A. Mock
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  4. Alfred D. Steinberg
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  5. Herbert C. Morse III
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  6. Rebecca J. Oakey
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  7. Thad A. Howard
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  8. Julie M. Rochelle
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  9. Michael F. Seldin
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Watson, M.L., D'Eustachio, P., Mock, B.A. et al. A linkage map of mouse Chromosome 1 using an interspecific cross segregating for the gld autoimmunity mutation. Mammalian Genome 2, 158–171 (1992). https://doi.org/10.1007/BF00302874

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  • DOI: https://doi.org/10.1007/BF00302874

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