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The effect of a lipid suspension on amitriptyline disposition

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Abstract

A 5-h infusion of a lipid suspension or saline was given on separate occasions to four healthy volunteers taking amitriptyline. Mean plasma levels of amitriptyline plus nortriptyline were 14% higher at the end of the lipid infusion but the difference was not statistically significant. Infusion of a lipid suspension is unlikely to materially affect the severity of amitriptyline intoxication.

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Authors and Affiliations

  1. Poisons Unit, Guy's Hospital, SE1 9RT, London, UK

    N. A. Minton & J. A. Henry

  2. Guy's Hospital, SE1 9RT, London, UK

    A. G. Goode

Authors
  1. N. A. Minton
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  2. A. G. Goode
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  3. J. A. Henry
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Minton, N.A., Goode, A.G. & Henry, J.A. The effect of a lipid suspension on amitriptyline disposition. Arch Toxicol 60, 467–469 (1987). https://doi.org/10.1007/BF00302392

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  • DOI: https://doi.org/10.1007/BF00302392

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