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Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22)

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Abstract

Inhalation pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22) were studied in male Wistar rats by use of a closed inhalation chamber system. CFC 21 was readily eliminated via metabolism.

However, CFC 22 underwent no detectable metabolism; pretreatment of the rats with DDT or phenobarbital did not stimulate metabolic transformation of the compound. Hence, formation of biologically relevant amounts of reactive intermediates from CFC 22 as a mechanism of toxicity seems unlikely.

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Authors and Affiliations

  1. Institut für Arbeitsphysiologie an der Universität Dortmund, Abteilung Toxikologie und Arbeitsmedizin, Ardeystr. 67, D-4600, Dortmund 1

    H. Peter & H. J. Wiegand

  2. Gesellschaft für Strahlen- und Umweltforschung, Abteilung Toxikologie, Ingolstädter Landstr. 1, D-8042, Neuherberg

    J. G. Filser

  3. Institut für Theoretische Chemie der Universität Stuttgart, Pfaffenwaldring 55, D-7000, Stuttgart 80, Federal Republic of Germany

    L. v. Szentpály

Authors
  1. H. Peter
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  2. J. G. Filser
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  3. L. v. Szentpály
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  4. H. J. Wiegand
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Peter, H., Filser, J.G., v. Szentpály, L. et al. Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22). Arch Toxicol 58, 282–283 (1986). https://doi.org/10.1007/BF00297122

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  • DOI: https://doi.org/10.1007/BF00297122

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