Abstract
Lead acetate was shown to stimulate a striking leukocytosis in young adult female mice. The effect was manifest 4 days after lead injection and continued throughout the following 4 days. At the higher treatment level, lead induced an increase of 300% for both monocytes and neutrophils. The leukocytosis was due primarily to the elevated levels of neutrophils as suggested by a decrease in the ratios of peripheral agranulocytes to granulocytes. No differences from normal leukocyte cytology were observed in blood samples collected from animals receiving lead.
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Hogan, G.R., Adams, D.P. Lead-induced leukocytosis in female mice. Arch. Toxicol. 41, 295–300 (1979). https://doi.org/10.1007/BF00296899
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DOI: https://doi.org/10.1007/BF00296899