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Bone mass and bone cellular variations after five months of physical training in rhesus monkeys: Histomorphometric study

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Summary

Five Rhesus Monkeys (Maccaca mulatta), a suitable nonhuman model, performed 5 months of ropeclimbing exercise. Duration of the training sessions was progressively increased to reach 1 hour/day after 1 month of training and was maintained until the end of the experiment. Bone mass parameters, bone resorption, and bone formation activity were measured by histomorphometric analysis on iliac crest bone biopsies before and after the experiment. Mineral apposition rate was measured in cortices and trabecular bone after double calcein labeling. Five months of rope-climbing exercise had determined a significant decrease of bone volume with a slight decrease of the number and thickness of trabeculae. This might induce an alteration of biomechanical properties of bone. These architectural modifications were associated with a nonsignificant decrease of bone resorption activity. But the main effect of training was an important decrease of bone formation activity without change of the mineral apposition rate. Endurance exercise at low intensity has determined a decreased bone turnover with osteoblastic depression. This animal experiment points out that exercise modalities might be important in the bone response to training and should be carefully defined for preventive use in humans.

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Authors and Affiliations

  1. Laboratoire de Biologie du Tissu Osseux (LBTO), Faculté de Médecine J. Lisfranc, 15, rue Ambroise Paré, 42023, Saint-Etienne Cedex, France

    Sandrine Bourrin, Laurence Vico & Christian Alexandre

  2. Division d'histophysiologie, Centre d'essais en vol, Centre d'Etudes et de Recherche en Médecine Aérospatiale (CERMA), 91228, Bretigny-Sur-Orge Cedex, France

    Erik Zerath & Claude Milhaud

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  1. Sandrine Bourrin
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  2. Erik Zerath
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  3. Laurence Vico
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  4. Claude Milhaud
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  5. Christian Alexandre
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Bourrin, S., Zerath, E., Vico, L. et al. Bone mass and bone cellular variations after five months of physical training in rhesus monkeys: Histomorphometric study. Calcif Tissue Int 50, 404–410 (1992). https://doi.org/10.1007/BF00296770

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  • DOI: https://doi.org/10.1007/BF00296770

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