Summary
In the present study, we compared the effects of good blood glucose control and that of aldose reductase inhibitor (Statil) treatment on diabetic retinal capillary basement membrane thickening in the diabetic BB-rat. Aggressive insulin treatment maintaining euglycaemia for 4 months prevented the characteristic basement membrane thickening in both the superficial and deep capillary beds of the diabetic retina. Statil treatment of hyperglycaemic rats for the same length of time prevented basement membrane thickening in the deep capillary bed but not in the superficial capillaries.
Article PDF
Similar content being viewed by others
References
Rohrbach DH, Martin GR (1982) Structure of basement membrane in normal and diabetic tissue. Ann NY Acad Sci 401: 203–209
Frank RN (1984) On the pathogenesis of diabetic retinopathy. Ophthalmology 91: 626–634
Frank RN, Keirn RJ, Kennedy A, Frank KW (1983) Galactose induced retinal capillary basement membrane thickening, prevention by sorbinil. Invest Ophthalmol Vis Sci 24: 1519–1524
Robison WG Jr., Kador PF, Kinoshita JH (1983) Retinal capillaries: basement membrane thickening by galactosemia prevented by aldose reductase inhibitor. Science 221: 1177–1179
Chandler ML, Shanon WA, DeSantis L (1984) Prevention of retinal capillary basement membrane thickening in diabetic rats by aldose reductase inhibitors. Invest Ophthalmol Vis Sci 25 [Suppl]: 159
Polsum R, Boot-Hardtford RP, Heath H (1983) The effects of long term treatment of streptozotocin diabetic rats with an aldose reductase inhibitor. Exp Eye Res 37: 507–15
Yagihashi S, Sima AAF (1985) Diabetic autonomic neuropathy. The distribution of structural changes in sympathetic nerves of the BB-rat. Am J Pathol 121: 138–147
McEwen T, Chakrabarti S, Sima AAF (1987) A rapid reproducible method for measurement of basement membrane thickness in biological structures. Comp Biol Med 17: 193–197
Robison WG Jr., Kador PF, Akagi Y, Kinoshita JH, Gonzalez R, Dvornik D (1986) Prevention of basement membrane thickening in retinal capillaries by a novel inhibitor of aldose reductase, Tolrestat. Diabetes 35: 295–299
Wise GN, Dollery CT, Henkind P (1971) The retinal circulation. Harper and Row, New York Evanstone San Francisco London, pp 21–54
Williamson JR, Vogler NJ, Kilo C (1971) Regional variation in width of basement membrane of muscle capillaries in man and giraffe. Am J Pathol 63: 359–370
Cohen MP (1986) Diabetes and protein glycosylation, measurement and biologic relevance. Springer, New York Berlin Heidelberg Tokyo, pp 5–16
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Chakrabarti, S., Sima, A.A.F. Pathogenetic heterogeneity in retinal capillary basement membrane thickening in the diabetic BB-rat. Diabetologia 30, 966–968 (1987). https://doi.org/10.1007/BF00295883
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00295883