Summary
A paraganglioma of the orbit in a 21-year-old woman is presented, containing oculo-cutaneous melanin in many tumor cells, occasionally adjacent to neurosecretory granules, and in macrophages. This tumor expands the list of neuroectodermal tumors with potential melaninization.
Similar content being viewed by others
References
Amemiya T, Kadoya M (1980) Paraganglioma in the orbit. J Cancer Res Clin Oncol 96: 169–179
Aouidj L, Dellagi K, Kchir N, Kujas M, Khaldi M, Bettaieb A, Zitonna MM (1988) Chémodectome de l'orbite. A propos d'un cas et revue de la littérature. Neurochirurgie 34: 201–204
Boesel CP, Suhan JP (1979) A pigmented choroid plexus carcinoma. Histochemical and ultrastructural studies. J Neuropathol Exp Neurol 38: 177–186
Curtis JL, Rubinstein LJ (1982) Pigmented olfactory neuroblastoma. A new example of melanotic neuroepithelial neoplasm. Cancer 49: 2136–2143
Cutler LS, Chaudhry AP, Topazian R (1981) Melanotic neuroectodermal tumor of infancy. An ultrastructural study, literature review, and reevaluation. Cancer 48: 257–270
DeChadarevian JP, Montes JL, O'Gorman AM, Freeman CR (1987) Maturation of cerebellar neuroblastoma into ganglioneuroma with melanosis. A histologic, immunocytochemical and ultrastructural study. Cancer 59: 69–76
Erdelyi E, VandenBerg SR, Raese J, Barchas JD, Rubinstein LJ, Herman MM (1981) Neuronal differentiation in the OTT-6050 mouse teratoma: enzymatic and immunofluorescence characterization of a tumor fraction showing melanogenesis in neuroepithelial cells. Virchows Arch [A] 393: 27–37
Fisher ER, Hazard JB (1952) Nonchromaffine paraganglioma of the orbit. Cancer 5: 521–524
Glenner GG, Grimley PM (1974) Tumors of the extraadrenal paraganglion system (including chemoreceptors). Atlas of tumor pathology, 2nd ser, fasc 9. Armed Forces Institute of Pathology, Washington, DC
Googe PB, Ferry JA, Bhan AK, Dickersin GR, Pilch BZ, Goodman M (1988) A comparison of paraganglioma, carcinoid tumor, and small cell carcinoma of the larynx. Arch Pathol Lab Med 112: 809–815
Gould VE, Wiedenmann B, Lee I, Schwechheimer K, Dockhorn-Dworniczak B, Radosevich JA, Moll R, Franke WW (1987) Synaptophysin expression in neuroendocrine neoplasms as determined by immunohistochemistry. Am J Pathol 126: 243–257
Greenberg R, Rosenthal I, Falk GS (1969) Electron microscopy of human tumors secreting catecholamines: correlation with biochemical data. J Neuropathol Exp Neurol 28: 475–482
Hahn JF, Netsky MG, Butler AB, Sperber EE (1976) Pigmented ganglioneuroblastoma: relation of melanin and lipofuscin to schwannomas and other tumors of neural crest origin. J Neuropathol Exp Neurol 35: 393–403
Hamid Q, Varndell IM, Ibrahim NB, Mingazzini P, Polak JM (1987) Extraadrenal paragangliomas. An immunocytochemical and ultrastructural report. Cancer 60: 1776–1781
Hawthorne MR, Makek MS, Harris JP, Fisch U (1988) The histopathological and clinical reatures of irradiated and nonirradiated temporal paragangliomas. Laryngoscope 98: 325–331
Herrick MK, Rubinstein LJ (1979) The cytological differentiation potential of pineal parenchymal neoplasms (true pinealomas). Brain 102: 289–320
Hunt SJ, Johnson PC (1989) Melanotic ganglioglioma of the pineal region. Acta Neuropathol 79: 222–225
Jellinger K, Böck F, Brenner H (1988) Meningeal melanocytoma. Acta Neurochir (Wien) 94: 78–87
Johnson RE, Scheithauer BW, Dahlin DC (1983) Melanotic neuroectodermal tumor of infancy. A review of 7 cases. Cancer 52: 661–666
Katenkamp D, Stiller D, Holzhausen HJ (1983) Morphologie des Neuroblastoms. Licht- und elektronenmikroskopische Untersuchungen als Beitrag zur Diagnose und Differentialdiagnose. Zentralbl Allg Pathol 127: 207–218
Lana-Peixoto MA, Lagos J, Silbert SW (1977) Primary pigmented carcinoma of the choroid plexus. A light and electron microscopical study. J Neurosurg 47: 442–450
Mawas J (1936) Sur un organ épithélial non décrit: le paraganglion infra-orbitaire. CR Acad Sci 202: 977–978
McCloskey JJ, Parker JC, Brooks WH, Blacker HM (1976) Melanin as a component of cerebral gliomas. The melanotic cerebral ependymoma. Cancer 37: 2373–2379
Mukai M, Torikata C, Iri H, Morikawa Y, Shimizu K, Shimoda T, Nukina N, Ihara Y, Kageyama K (1986) Expression of neurofilament triplet proteins in human neural tumors. An immunohistochemical study of paraganglioma, ganglioneuroma, ganglioneuroblastoma, and neuroblastoma. Am J Pathol 122: 28–35
Mullins JD (1980) A pigmented differentiating neuroblastoma. A light and ultrastructural study. Cancer 46: 522–528
Parizek J, Nemecek S, Cernoch Z, Heger L, Nozicka Z, Spacek J (1986) Melanotic neuroectodermal neurocranial tumor of infancy of extra-, intra- and subdural right temporal location: CT examination, surgical treatment, literature review. Neuropediatris 17: 115–123
Prabhakar S, Sawhney IMS, Chopra JS, Kak VK, Banerjee AK (1984) Hemibase syndrome: an unusual presentation of intracranial paraganglioma. Surg Neurol 22: 39–42
Rubinstein LJ, Northfield DWC (1964) The medulloblastoma and the so-called “arachnoidal cerebellar sarcoma”. A critical reexamination of a nosological problem. Brain 87: 379–412
Russell DS, Rubinstein LJ (1989) Pathology of tumours of the nervous system, 5th edn. E Arnold, London Melbourne Auckland p 960
Takahashi H, Nakashima S, Kumanishi T, Ikuta F (1987) Paraganglioma of the craniocervical region. An immunohistochemical study on tyrosine hydroxylase. Acta Neuropathol (Berl) 73: 227–232
Tavassoli FA (1986) Melanotic paraganglioma of the uterus. Cancer 58: 942–948
Venkataramana NK, Sastry Kolluri VR, Raj Kumar DV, Vasudev Rao T, Das BS (1989) Paraganglioma of the orbit with extension to the middle cranial fossa: case report. Neurosurgery 24: 762–764
Winston KR, Sotrel A, Schnit SJ (1987) Meningeal melanocytoma. Case report and review of the clinical and histological features. J Neurosurg 66: 50–57
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Paulus, W., Jellinger, K. & Brenner, H. Melanotic paraganglioma of the orbit: a case report. Acta Neuropathol 79, 340–346 (1989). https://doi.org/10.1007/BF00294673
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00294673