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Delayed maturation of the vagus nerve in sudden infant death syndrome

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Abstract

Abnormalities of the respiratory control system have been implicated in the cause of death in sudden infant death syndrome (SIDS). The vagus nerve is a major component of the neural regulation of respiration. Ultrastructural quantitative morphometry of myelinated and unmyelinated fibers was performed on cervical vagus nerves taken from 30 SIDS victims and 29 age-matched controls between 1 and 9 months of age. In SIDS infants, more small and fewer large myelinated vagal fibers were found than in controls, suggesting that the vagus nerve in SIDS is relatively immature. Delayed vagal nerve maturation, together with delays in central nervous system myelination and dendritic development, indicates a neural developmental delay in SIDS, the cause of which is undetermined.

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References

  1. Armstrong D, Sachis P, Bryan C, Becker L (1982) Pathological features of persistent infantile sleep apnea with reference to the pathology of sudden infant death syndrome. Ann Neurol 12:169–174

    Google Scholar 

  2. Asala SA, Bower AJ (1986) A electron microscope study of vagus nerve composition in the ferret. Anat Ambryol (Berl) 175:247–253

    Google Scholar 

  3. Becker LE (1984) Neuropathological basis for respiratory dysfunction in sudden infant death syndrome. In: Tildon JT, Roeder LM, Steinschneider A (es) Sudden infant death syndrome. Academic Press, New York, pp 99–114

    Google Scholar 

  4. Becker LE (1990) Neural maturational delay as a link in the chain of events leading to SIDS. Can J Neurol Sci 17:361–371

    Google Scholar 

  5. Bruce K, Becker LE (1991–92) Quantitation of medullary astrogliosis in sudden infant death syndrome. Pediatr Neurosurg 17:74–79

    Google Scholar 

  6. Daly M de B, Evans DHL (1953) Functional and histological changes in the vagus nerve of the cat after degenerative section at various levels. J Physiol (Lond) 120:579–595

    Google Scholar 

  7. De Neef KJ, Jansen JR, Versprille A (1982) Developmental morphology and physiology of rabbit vagus nerve. Brain Res 256:265–274

    Google Scholar 

  8. Feldman JL, McCrimmon DR, Smith JC, Ellenberger HH, Speck DF (1986) Respiratory pattern generation in mammals. In: von Euler C, Langercrantz H (eds) Neurobiology of the control of breathing. Raven Press, New York, pp 157–164

    Google Scholar 

  9. Ferriere G, Denef JF, Rodriguez J, Guzzetta F (1985) Morphometric studies of normal sural nerves in children. Muscle Nerve 8:697–704

    Google Scholar 

  10. Filiano JJ, Kinney HC (1992) Arcuate nucleus hypoplasia in the sudden infant death syndrome. J Neuropathol Exp Neurol 51:394–403

    Google Scholar 

  11. Guo Y-P, McLeod JG, Baverstock J (1987) Pathological changes in the vagus nerve in diabetes and chronic alcoholism. J Neurol Neurosurg Psychiatry 50:1449–1453

    Google Scholar 

  12. Jenq CB, Chung K, Coggeshall RE (1986) Postnatal loss of axons in normal rat sciatic nerve. J Comp Neurol 244:445–450

    Google Scholar 

  13. Kinney HC, Brody BA, Finkelstein DM, Vawter GF, Mandell F, Gilles FH (1991) Delayed central nervous system myelination in the sudden infant death syndrome. J Neuropathol Exp Neurol 50:29–48

    Google Scholar 

  14. Krous HF, Jordan J, Wen J, Farber JP (1985) Developmental morphometry of the vagus nerve in the opossum. Brain Res 352:155–159

    Google Scholar 

  15. Mei N, Condamin M, Boyer A (1980) The composition of the vagus nerve of the cat. Cell Tissue Res 209:423–431

    Google Scholar 

  16. Naeye RL, Ladis B, Drage JS (1976) Sudden infant death syndrome. A prospective study. Am J Dis Child 130:1207–1210

    Google Scholar 

  17. Pereyra PM, Zhang W, Schmidt M, Becker LE (1992) Development of myelinated and unmyelinated fibers of human vagus nerve during the first year of life. J Neurol Sci 10:107–113

    Google Scholar 

  18. Perrin DG, Cutz E, Becker LE, Bryan AC, Madapallimatum A, Sole MJ (1984) Sudden infant death syndrome: increased carotid-body dopamine and noradrenaline content. Lancet II:535–537

    Google Scholar 

  19. Quattrochi JJ, McBride PT, Yates AAJ (1985) Brainstem immaturity in sudden infant death syndrome: A quantitative rapid Golgi study of dendritic spines in 95 infants. Brain Res 325;39–48

    Google Scholar 

  20. Rognum TO, Saugstad OD, Øyasæter S, Olaisen B (1988) Elevated levels of hypoxanthine in vitreous humor indicate prolonged cerebral hypoxia in victims of sudden infant death syndrome. Pediatrics 82:615–618

    Google Scholar 

  21. Sachis PN, Armstrong DL, Becker LE, Bryan AC (1981) The vagus nerve and sudden infant death syndrome: A morphometric study. J Pediatr 98:278–280

    Google Scholar 

  22. Sachis PN, Armstrong DL, Becker LE, Bryan AC (1982) Myelination of the human vagus nerve from 24 weeks post-conceptional age to adolescence. J Neuropathol Exp Neurol. 41:466–472

    Google Scholar 

  23. Schäfer K, Friede RL (1988) The onset and rate of myelination in six peripheral and autonomic nerves of the rat. J Anat 159:181–195

    Google Scholar 

  24. Schröder JM, Bohl J, Brodda K (1978) Changes in the ratio between myelin thickness and axon diameter in the human developing sural nerve. Acta Neuropathol (Berl) 43:169–178

    Google Scholar 

  25. Schröder JM, Bohl J, von Bardeleben U (1988) Changes of the ratio between myelin thickness and axon diameter in human developing sural, femoral, ulnar, facial, and trochlear nerves. Acta Neuropathol 76:471–483

    Google Scholar 

  26. Siebert JR, Haas JE (1991) Enlargement of the tongue in sudden infant death syndrome. Pediatr Pathol 11:813–826

    Google Scholar 

  27. Steinschneider A (1977) Nasopharyngitis and the sudden infant death syndrome. Pediatrics 60:531–533

    Google Scholar 

  28. Takashima S, Becker LE (1985) Developmental abnormalities of medullary “respiratory centres” in sudden infant death syndrome. Exp Neurol 90:580–587

    Google Scholar 

  29. Takashima S, Becker LE (1991) Delayed dendritic development of catecholaminergic neurons in the ventrolateral medulla of children who died of sudden infant death syndrome. Neuropediatrics 22:97–99

    Google Scholar 

  30. Takashima S, Armstrong D, Becker L, Bryan C (1978) Cerebral hypoperfusion in the sudden infant death syndrome? Brain stem gliosis and vasculature. Ann Neurol 4:257–262

    Google Scholar 

  31. Takashima S, Armstrong D, Becker LE, Huber J (1978) Cerebral white matter lesions in sudden infant death syndrome. Pediatrics 62:155–159

    Google Scholar 

  32. Takashima S, Mito T, Becker LE (1985) Neuronal development in the medullary reticular formation in sudden infant death syndrome and premature infants. Neuropediatrics 16:76–79

    Google Scholar 

  33. Tonkin S (1983) Pharyngeal airway obstruction: physical signs and factors in its production. In: Tildon JT, Roeder LM, Steinschneider A (eds) Sudden infant death syndrome. Academic Press, New York, pp 453–465

    Google Scholar 

  34. Tranier S, Bougle D, Pottier M, Venezia P (1989) Maturation of peripheral nerves in preterm infants: proprioceptive and motor nerve conductions of tibial nerve. Brain Dev 11:215–220

    Google Scholar 

  35. Valdes-Dapena M (1992) A pathologist's perspective on the sudden infant death syndrome — 1991. Pathol Annu 27:133–164

    Google Scholar 

  36. Williams AL, Uren EC, Bretherton L (1984) Respiratory viruses and sudden infant death. Br Med J 288:1491–1493

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology (Neuropathology), University of Toronto, M5G 1X8, Ontario, Canada

    Laurence E. Becker

  2. Department of Pathology, The Hospital for Sick Children, 555 University Avenue, M5G 1X8, Toronto, Ontario, Canada

    Laurence E. Becker

Authors
  1. Laurence E. Becker
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  2. Weixian Zhang
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  3. Pedro M. Pereyra
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Additional information

This paper was prepared with the assistance of Medical Publications, The Hospital for Sick Children, Toronto, Ontario, Canada

Supported by grants from SIDS. Alliance and Canadian Foundation for the study of infant deaths

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Becker, L.E., Zhang, W. & Pereyra, P.M. Delayed maturation of the vagus nerve in sudden infant death syndrome. Acta Neuropathol 86, 617–622 (1993). https://doi.org/10.1007/BF00294301

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  • DOI: https://doi.org/10.1007/BF00294301

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