Abstract
The anterior hippocampus and the entorhinal cortex of 167 non-demented individuals (controls) and 22 patients with Alzheimer's dementia were investigated. Senile plaques and neurofibrillary tangles were counted on paraffin sections stained with methenamin silver and Gallyas silver iodide, respectively. The results showed that both senile plaques and neurofibrillary tangles areal densities (lesions per mm2) correlated significantly with age in the control collective. No significant correlation between Alzheimer's disease lesions and age was found in patients with Alzheimer's dementia. Positive and significant correlation between senile plaques and neurofibrillary tangles was found in the control group but not in the Alzheimer group. Control individuals (n = 43, matched for age with the Alzheimer group) displayed both plaques and tangles. In this subgroup neither plaques nor tangles correlated with age; however, there was a significant correlation betwen senile plaques and neurofibrillary tangles. We hypothesize that the continuous activity of underlying processes associated with senile plaques and neurofibrillary tangles formation or resolution might lead to the unbalanced production of these lesions in Alzheimer's disease.
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References
Alafuzoff I, Iqbal K, Friden H, Adolfsson R, Winblad B (1987) Histopathological criteria for progressive dementia disorders: clinico-pathological correlation and classification by multivariate data analysis. Acta Neuropathol (Berl) 74:209–225
Armstrong RA, Myers D, Smith CU, Cairns N, Luthert PJ (1991) Alzheimer's disease: the relationship between the density of senile plaques, neurofibrillary tangles and A4 protein in human patients. Neurosci Lett 123:141–143
Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42: 631–639
Braak H, Braak E, Grundke-Iqbal I, Iqbal K (1986) Occurrence of neuropil threads in the senile human brain and Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neurosci Lett 65: 351–355
Crystal H, Dickson D, Fuld P, Masur D, Scott R, Mehler M, et al (1988) Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer's disease. Neurology 38:1682–1687
Gallyas F (1971) Silver staining of Alzheimer's neurofibrillary changes by means of physical development. Acta Morphol Acad Sci Hung 19:1–8
Khatchaturian Z (1985) Diagnosis of Alzheimer's disease. Arch Neurol 42:1097–1105
Mann D, Tucker C, Yates P (1987) The topographic distribution of senile plaques and neurofibrillary tangles in the brains of non-demented persons of different age. Neuropathol Appl Neurobiol 13:123–139
McKee AC, Kosik KS, Kowall NW (1991) Neuritic pathology and dementia in Alzheimer's disease. Ann Neurol 30:156–165
Probst A, Anderton BH, Brion JP, Ulrich J (1989) Senile plaque neurites fail to demonstrate anti-paired helical filament and anti-microtubule-associated protein-tau immunoreactive proteins in the absence of neurofibrillary tangles in the neocortex. Acta Neuropathol (Berl) 77:430–436
Probst A, Langui D, Ulrich J (1991) Alzheimer's disease: a description of the structural lesions. Brain Pathol 1:229–239
Silverman W, Popovitch E, Schupf N, Zigman WB, Rabe A, Sersen E, Wisniewski HM (1993) Alzheimer neuropathology in mentally retarded adults: statistical independence of regional amyloid plaque and neurofibrillary tangle densities. Acta Neuropathol 85:260–266
Tomlinson BE, Blessed G, Roth M (1968) Observations on the brains of non demented old people. J Neurol Sci 7:331–356
Ulrich J (1985) Alzheimer changes in non demented patients younger than sixty five: possible early stages of Alzheimer's disease and senile dementia of Alzheimer type. Ann Neurol 17:273–277
Yajima G (1987) Periodic acid methenamin silver stain. Med Technol 5:1041–1046
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Supported by the “Ciba-Geigy Jubiläum Stiftung”, and a grant from the Swiss National Foundation (grant no. 31-32314.91) (to J.U.)
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Lagui, D., Probst, A. & Ulrich, J. Alzheimer's changes in non-demented and demented patients: a statistical approach to their relationships. Acta Neuropathol 89, 57–62 (1995). https://doi.org/10.1007/BF00294260
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DOI: https://doi.org/10.1007/BF00294260