Abstract
Mutations in paired-box-containing (Pax) genes have recently been found to be the primary lesions underlying human genetic disorders such as Waardenburg's Syndrome type 1 and mouse developmental mutants such as undulated (un), splotch (Sp), and small eye (Sey). In addition, PAX-6 is a strong candidate gene for aniridia in man. Eight independent Pax genes have been isolated in the mouse. All eight map to distinct regions of the mouse genome; they do not appear to be clustered in the same way as some groups of homeobox-containing genes. We have now mapped the human homologs of all eight of these genes; PAX genes are found on human Chromosomes (Chr) 1, 2, 7, 9, 10, 11, and 20.
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Pilz, A.J., Povey, S., Gruss, P. et al. Mapping of the human homologs of the murine paired-box-containing genes. Mammalian Genome 4, 78–82 (1993). https://doi.org/10.1007/BF00290430
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DOI: https://doi.org/10.1007/BF00290430