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Assignment of a gene for human quinoid-dihydropteridine reductase (QDPR, EC 1.6.5.1) to chromosome 4

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Summary

An acrylamide gel electrophoretic procedure is described which allows the separation of human quinoid-dihydropteridine reductase (QDPR), EC 1.6.5.1) from the homologous enzyme expressed in established rodent cell lines. The human enzyme marker segregates exclusively with chromosome 4 in a series of well characterized man-mouse somatic cell hybrid clones from our clone bank. This observation supports the assignment of a structural gene for QDPR to human chromosome 4.

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Authors and Affiliations

  1. Institut für Humangenetik der Universität Bonn, Wilhelmstraße 31, D-5300, Bonn, Federal Republic of Germany

    P. Kuhl, K. Olek & P. Wardenbach

  2. Institut für Humangenetik der Universität Münster, Vesaliusweg 12-14, D-4400, Münster, Federal Republic of Germany

    K. -H. Grzeschik

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  1. P. Kuhl
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  2. K. Olek
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  3. P. Wardenbach
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  4. K. -H. Grzeschik
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Kuhl, P., Olek, K., Wardenbach, P. et al. Assignment of a gene for human quinoid-dihydropteridine reductase (QDPR, EC 1.6.5.1) to chromosome 4. Hum Genet 53, 47–49 (1979). https://doi.org/10.1007/BF00289450

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  • DOI: https://doi.org/10.1007/BF00289450

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