Summary
Chromosomal aberrations, sister chromatid exchanges, mitotic index and cell kinetics were observed in human peripheral lymphocytes after treatment with four different concentrations (0.0125, 0.025, 0.05 and 0.1 μg/ml) of benzene hexachloride (BHC), an organochlorine pesticide. Cells were treated with BHC for 24, 48 and 72h. There was a dose-dependent increase in the frequency of chromosomal aberrations and sister chromatid exchanges. A significant decrease in mitotic index was observed at all concentrations and times of exposure. BHC did not show a significant effect on cell kinetics.
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Rupa, D.S., Reddy, P.P. & Reddi, O.S. Genotoxic effect of benzene hexachloride in cultured human lymphocytes. Hum Genet 83, 271–273 (1989). https://doi.org/10.1007/BF00285170
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DOI: https://doi.org/10.1007/BF00285170