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The syncarcinogenic effect of methylcholanthrene and dimethylnitrosamine in Swiss mice

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Summary

The combined application of MCA (i.g.) and DMN (i.p.) to Swiss mice resulted in an increased incidence of tumors and in a decreased tumor latency, compared with the animals treated with each compound alone. In the MCA+DMN group the rate of lung carcinomas and neoplasms of the kidney was found to be significantly enhanced, while the DMN group showed an increase of vascular tumors. In the MCA group malignant lymphomas were seen more frequently than in the other groups. The findings concerning the lung and kidney were interpreted as a syncarcinogenic effect of the combined application of MCA + DMN.

Zusammenfassung

Die kombinierte Verabreichung von Methylcholanthren (MCA) (intragastrisch) und Dimethylnitrosamin (DMN) (intraperitoneal) führte bei Swiss-Mäusen zu erhöhter Tumorrate bei verkürzter Latenzzeit im Vergleich zu Tieren, die jeweils nur mit einer der beiden Substanzen behandelt wurden. In der MCA+DMN-Gruppe fanden sich vermehrt Lungencarcinome, Neoplasmen der Nieren und Lymphome. Bei den Tieren der DMN-Gruppe zeigten sich gehäuft Gefäßtumoren. Die Befunde der MCA + DMN-Gruppe werden als syncarcinogene Wirkung der Substanzen diskutiert.

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Authors and Affiliations

  1. The Eppley Institute for Research in Cancer, Omaha, Nebraska

    A. Cardesa, P. Pour, M. Rustia, J. Althoff & U. Mohr

  2. Abteilung für Experimentelle Pathologie, Medizinische Hochschule, Hannover, West Germany

    A. Cardesa, P. Pour, M. Rustia, J. Althoff & U. Mohr

Authors
  1. A. Cardesa
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  2. P. Pour
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  3. M. Rustia
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  4. J. Althoff
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  5. U. Mohr
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Supported by U. S. Public Health Service contract 43-68-959 from the National Cancer Institute.

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Cardesa, A., Pour, P., Rustia, M. et al. The syncarcinogenic effect of methylcholanthrene and dimethylnitrosamine in Swiss mice. Z. Krebsforsch. 79, 98–107 (1973). https://doi.org/10.1007/BF00284384

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  • DOI: https://doi.org/10.1007/BF00284384

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