Summary
The genes encoding apolipoproteins CI, CII, and E have been previously localized to chromosome 19. By use of rodent-human hybrid cell lines containing translocations of chromosome 19 we have now mapped these three genes to the region 19p13–19q13 and most probably 19p13–19 cen. The clustering of APOC1, APOC2, and APOE must reflect their common evolutionary background and suggests that they may be coordinately regulated. Polymorphisms detected for any one gene will be useful for inheritance studies of all three.
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References
Barker WC, Dayhoff MD (1977) Evolution of lipoproteins based on protein sequence data. Comp Biochem Physiol 57B:309–315
Brook JD, Shaw DJ, Meredith L, Bruns GAP, Harper PS (1984) Localization of genetic markers and orientation of the linkage group on chromosome 19. Hum Genet 68:2820285
Bruns GAP, Karathanasis SK, Breslow JL (1983) Human apoprotein AI-CIII gene complex is located on chromosome 11. Arteriosclerosis 4:97–102
Cheung P, Kao F-T, Law ML, Jones C, Pack TT, Chan L (1984) Localization of the structural gene for human apolipoprotein AI on the long arm of human chromosome 11. Proc Natl Acad Sci USA 81:508–511
Donald JA, Wallis SC, Kessling A, Tippett P, Robson EB, Ball S, Davies KE, Scambler P, Berg K, Heiberg A, Williamson R, Humphries SE (1985) Linkage relationships of the gene for apolipoprotein CII with loci on chromosome 19. Hum Genet 69:39–43
Feinberg AP, Vogelstein B (1984) A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 137:266–267
Havel RJ, Eder HA, Bragdon JH (1955) the distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34:1345–1353
Herbert PN, Assmann G, Gotto AM Jr, Fredrikson DS (1983) Familial lipoprotein deficiency: Abetalipoproteinemia, hypobeta-lipoproteinemia, and Tangier disease. In: Stanbury JB, Wyngaarden JB, Fredrickson DS, Goldstein JL, Brown MS (eds) The inherited basis of metabolic diseases, 5th edn. McGraw Hill, New York, pp 589–621
Humphries SE, Berg K, Gill L, Cumming AM, Robertson FW, Stalenhoef AFJ, Williamson R, Borresen AL (1984) The gene for apolipoprotein C-II is closely linked to the gene for apolipoprotein E on chromosome 19. Clin Genet 26:389–396
Karathanasis SK, McPherson J, Zannis VI, Breslow JL (1983a) Linkage of human apolipoproteins AI and CIII genes. Nature 304: 371–373
Karathanasis SK, Zannis VI, Breslow JL (1983b) Isolation and characterization of the human apolipoprotein AI gene. Proc Natl Acad Sci USA 80:6147–6151
Knott TJ, Eddy RL, Robertson ME, Priestley LM, Scott J, Shows TB (1984a) Chromosomal localization of the human apoprotein CI gene and of a polymorphic apoprotein AII gene. Biochem Biophys Res Commun 125:299–306
Knott TJ, Robertson ME, Priestley LM, Urdea M, Wallis S, Scott J (1984b) Characterization of mRNAs encoding the precursor for human apolipoprotein CI. Nucl Acids Res 12:3909–3915
Knott TJ, Wallis SC, Robertson ME, Priestley LM, Rall LB, Urdea M, Scott J (to be published) Human apoprotein AII gene: Structure and expression. Nucl Acids Res
Law SW, Gray G, Brewer HB Jr, Sakaguchi AY, Naylor SL (1984) Human apolipoprotein AI and CIII genes reside in the p11q13 region of chromosome 11. Biochem Biophys Res Commun 118:934–941
McKusick VA (1985) Human gene map 1 December 1984. Clin Genet 27:207–239
McLean JW, Elshourbagy NA, Chang DJ, Mahley RW, Taylor JM (1984) Human apolipoprotein E mRNA: cDNA cloning and nucleotide sequencing of a new variant. J Biol Chem 259:6498–6504
Miller NE, Rao SN, Alaupovic P, Noble N, Slack J, Brunzell JD, Lewis B (1981) Familial apoliprotein CII deficiency: Plasma lipoproteins and apolipoproteins in heterozygous and homozygous subjects and effects of plasma infusion. Eur J Clin Invest 11:69–75
Myklebost O, Williamson B, Markham AF, Myklebost SR, Rogers J, Woods DE, Humphries SE (1984a) The isolation and characterization and cDNA clones for human apolipoprotein CII. J Biol Chem 259:4401–4404
Myklebost O, Rogue S, Olaisen B, Gedde-Dahl T, Prydz H (1984b) The locus for apolipoprotein CII is closely linked to the apolipoprotein E locus on chromosome 19 in man. Hum Genet 67:309–312
Protter AA, Levy-Wilson B, Miller J, Bencen G, White T, Seilhamer JJ (1984) Isolation and sequence analysis of the human apolipoprotein CIII gene and the intergenic region between the apo AI and apo CIII genes. DNA 3:449–456
Rall SC Jr, Weisgraber KH, Innerarity TL, Mahley RW (1982) Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects. Proc Natl Acad Sci USA 79:4696–4700
Schamaun O, Olaisen B, Mevaj B, Gedde-Dahl TR, Ehnholm C, Teisberg P (1984) The two apolipoprotein loca apoA-I and A-IV are closely linked in man. Hum Genet 68:181–184
Sharpe CR, Sidoli A, Lucero MA, Shoulders CC, Baralle FE (1984) Human apolipoproteins AI, AII, CII and CIII: cDNA sequences and mRNA abundance. Nucleic Acids Res 12:3917–3932
Shaw DJ, Meredith AL, Sarfarazi M, Hicson SM, Brook JD, Myklebost O, Harper PS (1985) The apolipoprotein CII gene: Subchromosomal localization and linkage to the myotonic dystrophy locus. Hum Genet (to be published)
Paik Y-K, Chang OJ, Reardon CA, Davies GE, Mahley RW, Taylor JM (1985) Nucleotide sequence and structure of the human apolipoprotein E gene. Proc Natl Acad Sci USA 82:3449
Wallis SC, Donald JA, Forrest LA, Williamson R, Humphries SE (1984) The isolation of a genomic clone containing the apolipoprotein CII gene and the detection of linkage disequilibrium between two common DNA polymorphisms around the gene. Hum Genet 68:286–289
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Scott, J., Knott, T.J., Shaw, D.J. et al. Localization of genes encoding apolipoproteins CI, CII, and E to the p13→cen region of human chromosome 19. Hum Genet 71, 144–146 (1985). https://doi.org/10.1007/BF00283370
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DOI: https://doi.org/10.1007/BF00283370