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Chromosomal rearrangements with a common breakpoint at 6p23 in five cases of myeloid leukemia

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Summary

Rearrangement of the short arm of chromosome 6 with a breakpoint at 6p23 was found in five patients with myeloid leukemia. Three of them had different morphological variants of AML (M2, M3, M4) and two blastic crisis of Ph1 negative and Ph1 positive CML. Identical translocation, t(6;9)(p23;q34), was revealed in two patients. One of them had AML (M2), the other blastic crisis of Ph1 negative CML. The blast cells of the last patient were morphologically similar to those in the M2 variant of AML.

Translocation (6;9)(q23;q34) was also detected in two AML patients of Rowley and Potter (1976).

The role of the breakpoint at 6p23 in myeloid malignancies needs further investigation.

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References

  • Mitelman F, Levan G (1981) Clustering of aberrations to specific chromosomes in human neoplasms. IV. A survey of 1,871 cases. Hereditas 95:79–139

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  • Rowley JD, Potter D (1976) Chromosomal banding patterns in acute nonlymphocytic leukemia. Blood 47:705–721

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Authors and Affiliations

  1. Laboratory of Cytogenetics, All-Union Cancer Research Center, AMS USSR, Kashirskoye shosse 24, 115 478, Moscow, USSR

    E. W. Fleischman, E. L. Prigogina, G. W. Iljinskaja, L. N. Konstantinova, G. P. Puchkova, M. A. Volkova, M. A. Frenkel & S. A. Balakirev

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  1. E. W. Fleischman
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  2. E. L. Prigogina
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  3. G. W. Iljinskaja
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  4. L. N. Konstantinova
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  5. G. P. Puchkova
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  6. M. A. Volkova
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  7. M. A. Frenkel
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  8. S. A. Balakirev
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Fleischman, E.W., Prigogina, E.L., Iljinskaja, G.W. et al. Chromosomal rearrangements with a common breakpoint at 6p23 in five cases of myeloid leukemia. Hum Genet 64, 254–256 (1983). https://doi.org/10.1007/BF00279404

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  • DOI: https://doi.org/10.1007/BF00279404

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