Summary
We report the successful use of a new method described by Gosden and Borck (1977) in two cases of anencephaly; according to this method ‘rapidly adhering cells’ are identified as neural cells of a specific morphology. Although the original method described adherence of cells during the first 20 h, we were able to identify a considerable number of such cells after a delay of three days due to mailing of the amniotic fluid.
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Gosden, C. M., Brock, D. J. H.: Morphology of rapidly adhering amniotic fluid cells as an aid to the diagnosis of neural tube defects. Lancet 1977I, 919–922
Gosden, C. M., Brock, D. J. H., Eason, P.: The origin of the rapidly adhering cells found in amniotic fluids from fetuses with neural tube defects. Clin. Genet. 12, 193–201 (1977)
Nelson, M. M., Ruttiman, M. T., Brock, D. J. H.: Predictive value of amniotic fluid macrophages in gross C.N.S. defects. Lancet 1974I, 504
Sutherland, G. R., Brock, D. J. H., Scrimgeour, J. B.: Amniotic fluid macrophages and anencephaly. Lancet 1973II, 1098–1099
Sutherland, G. R., Brock, D. J. H., Scrimgeour, J. B.: Amniotic fluid macrophages and the antenatal diagnosis of anencephaly and spina bifida. J. Med. Genet. 12, 135–137 (1975)
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Voigtländer, T., Müller, U. & Schroeder, T.M. Rapidly adhering cells in two cases of anencephaly. Hum Genet 45, 107–110 (1978). https://doi.org/10.1007/BF00277582
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DOI: https://doi.org/10.1007/BF00277582