Abstract
The interaction between three heavy metals, cadmium, mercury and zinc was investigated. The metals were injected Subcutaneously into the hind leg of male rats of approximately 200 g body weight in a volume of 0.2 ml either alone or in combination with another metal. It has been shown that interaction started at the site of injection, at which the retention of one metal was increased by the presence of the other over a 48 h period. Besides this local interaction, probably based on competition for a carrier compound, there were differences in distribution. Analysis of the data indicates that metals injected simultaneously can influence the distribution of each other and, although each of the studied metal is able to induce thionein, the observed interactions cannot be explained by a single mechanism.
Zusammenfassung
Die Wechselwirkung zwischen den drei Schwermetallen Kadmium, Quecksilber und Zink wurde untersucht. Die Metalle wurden etwa 200 g schweren männlichen Ratten in einem Volumen von 0,2 ml entweder allein oder in Kombination mit dem anderen Metall subcutan in das Hinterbein injiziert. Es ist gezeigt worden, daß die Wechselwirkung an der Injektionsstelle beginnt, wobei die Retention eines Metalls durch die Gegenwart eines anderen über eine Periode von 48 Std erhöht wird. Neben dieser lokalen Wechselwirkung, die wahrscheinlich auf der Konkurrenz gegenüber einem carrier beruht, wurden Unterschiede in der Verteilung aufgefunden. Die Analyse unserer Daten zeigt, daß gleichzeitig injizierte Metalle sich in ihrer Verteilung beeinflussen. Obgleich jedes der untersuchten Metalle die Thioneinbildung zu induzieren vermag, können die beobachteten Wechselwirkungen nicht durch einen einheitlichen Mechanismus erklärt werden.
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Supported partly by International Atomic Energy Agency Grant Number 1530/RB
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Magos, L., Webb, M. The interaction between cadmium, mercury and zinc — administered subcutaneously in a single injection. Arch. Toxicol. 36, 53–61 (1976). https://doi.org/10.1007/BF00277563
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DOI: https://doi.org/10.1007/BF00277563