Summary
The power of experiments aimed at detecting linkage between a quantitative locus and a marker locus, both segregating in the backross or F2 generation of a cross between two inbred lines, is examined. Given that the two lines are close to fixation for alternative alleles of both marker locus and quantitative locus, it is concluded that experiments involving a few thousand offspring should be able to detect close linkages involving quantitative loci (or groups of loci) having rather modest effects (i.e., that contribute, say, 1% of the total phenotypic variance in the F2).
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Literature
Al-Murrani, W.K.; Roberts, R.C.: Genetic variation in a line of mice selected to its limit for high body weight. Anim. Prod. 19, 273–289 (1974)
Briggs, D.M.; Nordskog, A.W.: Influence of sex chromosomes on laying house performance of chickens. Brit. Poultry Sci. 14, 403–412 (1973)
Chai, L.K.: Analysis of quantitative inheritance of body size in mice. V. Effects of small number of polygenes on similar genetic background. Genetical Res. 11, 239–246 (1968)
Elston, R.C.; Stewart, J.: Biometrical genetics with one or two loci: The inheritance of physiological characters in mice. Genetics 73, 675–693 (1973a)
Elston, R.C.; Stewart, J.: The analysis of quantitative traits for simple genetic models from parental, F1 and backcross data. Genetics 73, 695–711 (1973b)
Falconer, D.L.: Introduction to Quantitative Genetics. Edinburgh: Oliver and Boyd, 1960
Henderson, S.A.; Edwards, R.G.: Chiasma frequency and maternal age in mammals. Nature 218, 22–28 (1968)
Jayakar, S.D.: On the detection and estimation of linkage between a locus influencing a quantitative character and a marker locus. Biometrics 26, 451–464 (1970)
Law, C.N.: The location of genetic factors affecting a quantitative character in wheat. Genetics 53, 487–498 (1966)
McMillan, I.; Robertson, A.: The power of methods for the detection of major genes affecting quantitative traits. Heredity 32, 349–356 (1974)
Ohno, S.: Sex Chromosomes and Sex-linked Genes. Berlin: Springer, 1967
Pollack, D.: Personal communication (1974)
Scheffé, H.: The Analysis of Variance. New York: Wiley 1959
Soames, R.G.: Linkage relationships in Domestic Fowl. J. of Heredity 64, 217–221 (1973)
Spickett, S.G.; Thoday, J.M.: Regular responses to selection. 3. Interaction between located polygenes. Genetical Res. 7, 96–121 (1966)
Stewart, J.: Biometrical genetics with one or two loci. I. The choice of a specific genetic model. Heredity 24, 211–224; II. The estimation of linkage. Heredity 24, 225–238 (1969)
Taylor, B.A.: Genetic relationships between inbred strains of mice. J. of Heredity 63, 83–86 (1972)
Wehrhahn, C.; Allard, R.W.: The detection and measurement of the effects of individual genes involved in the inheritance of a quantitative character in wheat. Genetics 51, 109–119 (1965)
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Communicated by A. Robertson
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Soller, M., Brody, T. & Genizi, A. On the power of experimental designs for the detection of linkage between marker loci and quantitative loci in crosses between inbred lines. Theoret. Appl. Genetics 47, 35–39 (1976). https://doi.org/10.1007/BF00277402
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DOI: https://doi.org/10.1007/BF00277402