Skip to main content
SpringerLink
Log in

Periosteocyte demineralization in disuse osteoporosis

The effect of calcitonin

  • Published:
International Orthopaedics Aims and scope Submit manuscript

Summary

We have investigated disuse osteoporosis in the calcaneum of the rabbit. Periosteocytic demineralization is an accurate indication of the degree of osteoporosis. It is influenced by the degree of skeletal maturity and the administration of calcitonin.

Résumé

L'étude des paramètres classiques de l'ostéoporose (ostéogénèse, résorption, volume absolu osseux et volume trabéculaire osseux), nous a permis dans un premier temps de nous assurer que nous disposions d'un modèle expérimental satisfaisant. Puis nous avons analysé la valeur de la mesure de la déminéralisation périostéocytaire dans l'étude de l'ostéoporose d'immobilisation. La déminéralisation périostéocytaire est différente suivant le degré de maturation squelettique et elle est freinée par l'administration de calcitonine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Arnold, J. S., Frost, H. M., Buss, R. O.: The osteocyte as a bone pump. Clin. Orthop. 78, 47–55 (1971)

    Google Scholar 

  2. Balsan, S., Jehanne, M.: Action comparée de la T.C.T. et du phosphore à forte dose sur la calciurie des enfants immobilisés. Arch. Franç. Péd. 28, 929–944 (1971)

    Google Scholar 

  3. Baud, C. A.: Morphologie et structure infra-microscopique des ostéocytes. Acta Anat. 51, (3), 209–225 (1962)

    Google Scholar 

  4. Baud, C. A., Pouezat, J. A.: Données microradiographiques quantitatives sur le minéral osseux dans l'ostéoporose postraumatique. Rhumatologie 25 (2), 53–55 (1973)

    Google Scholar 

  5. Bernard, J., Meunier, P.: L'analyse morphométrique de l'ostéolyse périostéocytaire. Son application au diagnostic des hyperparathyroïdies. Ann. Anat. Pathol. (Paris) 20 (4) 367–380 (1975)

    Google Scholar 

  6. Bohr, H.: Calcium metabolism during immobilizsation. Calcium Metabolism, Bone, and Metabolic Bone Disease, pp. 39–42, 1975

  7. Bordier, P. H., Matrajt, H., Miravet, L., Hioco, D.: Mesure histologique de la masse et de la résorption des travées osseuses. Pathol. Biol. 12 (23–24), 1238–1243 (1964)

    Google Scholar 

  8. Burckhart, J. M., Jowsey, J.: Parathyroïd and thyroïd hormones in the development of immobilization osteoporosis. Endocrinology 81, 1053–1062 (1967)

    Google Scholar 

  9. Cabanela, M. E., Jowsey, J.: The effects of phosphonates on experimental osteoporosis. Calcif. Tiss. Res. 8, 114–120 (1971)

    Google Scholar 

  10. Cauchoix, J., Duriez, J.: La lyse péri-ostéocytaire. SICOT, Xe Congrès, Paris, Sept. 1968

  11. Chiroff, R. T., et al.: The effect of Calcitonin on immobilization osteopenia. J. Bone Joint Surg. [Am.] 52, 1138–1146 (1970)

    Google Scholar 

  12. Dhem, A.: Recherches expérimentales sur l'ostéoporose aiguë. Ann. Anat. Pathol. 6 (4), 498–501 (1961)

    Google Scholar 

  13. De Guembecker, C., Duriez, J.: Effet de la calcitonine sur la fixation calcique péri-ostéocytaire et sur l'activité ostéogénique dans l'ostéoporose postménopausique. Rhumatologie 36–1977, VII, 2 (1978)

    Google Scholar 

  14. Delling, G., Schaffer, A., Schleicher, H. J., Ziegler, R.: The effect of Calcitonin on disuse atrophy of bone in the rat. Calcif. Tiss. Res. 6, 143–150 (1970)

    Google Scholar 

  15. Duriez, J., Cauchoix, J.: Le rôle des ostéocytes dans la résorption du tissu osseux. La Presse Méd. 25, 1297–1301 (1967)

    Google Scholar 

  16. Duriez, J., Flautre, B.: Ostéogénèse, activité ostéocytaire et calcitonine. Acta Orthop. Belg. 39 (2) 471–478 (1973)

    Google Scholar 

  17. Duriez, J., Flautre, B.: Fixation calcique péri-ostéocytaire sous calcitonine. Etude microradiographique à l'analyseur automatique d'images dans huit cas d'ostéogénèse imparfaite. La Nouv. Presse Méd. 4, 97–100 (1975)

    Google Scholar 

  18. Engstrom, A., Amprino, R.: X-ray diffraction and X-ray absorption studies of immobilized bones. Experientia 6, 267 (1950)

    Google Scholar 

  19. Geiser, M., Trueta, J.: Muscle action, bone rarefaction and bone formation. J. Bone Joint Surg. [Br.] 40, 282 (1958)

    Google Scholar 

  20. Hantman, D. A.: Attemps to prevent disease osteoporosis by treatment with calcitonin, longitudinal compression, and supplementary calcium and phosphate. J. Clin. Endocrinol. Metab. 36, 845–858 (1973)

    Google Scholar 

  21. Hantman, D. A., Donaldson, C. L., Wasserman, S. I., Hulley, S. B.: Administration of calcitonin or calcium and phosphate during prolonged bed rest. Clin. Res. 19, 476 (1971)

    Google Scholar 

  22. Hardt, A. B.: Early metabolic response of bone to immobilization. J. bone Joint Surg. [Am.] 54, 119–124 (1972)

    Google Scholar 

  23. Hoffman, R. A.: Immobilization: Comparison of calcium and phosphorus excretion with bone density changes during restraint in immature Macaca nemestrima primates. Aerosp. Med. 43, 376–383 (1972)

    Google Scholar 

  24. Jowsey, J., Riggs, B. L., Kelly, P. J.: Mineral Metabolism in osteocytes. Proc. Mayo Clinic 39, 480–484 (1964)

    Google Scholar 

  25. Kazarian, L. E., von Gierke, H. E.: Bone loss as a result of immobilization and chelation, preliminary results in Macaca Mulatta. Clin. Orthop. 76, 65–67 (1969)

    Google Scholar 

  26. Kenner, G. H., Gabrieısone, N., Lovell, J. E., Marshall, A. E.: Electrical Modification of Disuse Osteoporosis. Calcif. Tiss. Res. 18, 111–117 (1975)

    Google Scholar 

  27. Kharmosh, O., Saville, P. D.: The effect of motor denervation on muscle and bone in the rabbit's hind limb. Acta Orthop. Scand. 36, 361–370 (1965)

    Google Scholar 

  28. Krempien, B., Manegold, C., Ritz, E., Bommer, J.: The influence of immobilization on osteocyte morphology. Osteocyte differential count and electron microscopical studies. Virchows Arch. [Pathol. Anat.] 370, 55–68 (1976)

    Google Scholar 

  29. Krook, L., Whalen, J., Lesser, G., Berens, D.: Experimental studies on Osteoporosis. Methods Achiev. Exp. Pathol. 7, 72–108 (1975)

    Google Scholar 

  30. Lacroix, P., Ponlot, R.: Remarques sur l'histo-pathologie de l'ostéoporose post-traumatique. Acta Chir. Belg. 56 (suppl. 1), 149–164 (1957)

    Google Scholar 

  31. Landry, M., Fleish, M.: The influence of immobilization on bone formation as evaluated by osseous incorporation of tetra-cyclines. J. Bone Joint Surg. [Br.] 46, 764–771 (1964)

    Google Scholar 

  32. Lindgren, U.: The effect of thyroparathyroïdectomy-Development of disuse osteoporosis in adult rat. Clin. Orthop. Rel. Res. 118, 251–256 (1976)

    Google Scholar 

  33. Lozupone, E., Marotti, G., S Aquilino, P.: Appositional growth rate in the spongiosa of unloaded long bones of the dog. Anat. Anz. 138, 259–265 (1975)

    Google Scholar 

  34. Mattson, S.: The reversibility of disuse osteoporosis. Experimental studies in the adult rat. Acta Orthop. Scand. (suppl.) 144 (1972)

  35. Meunier, P., Vignon, G., Vauzelle, J. L.: Méthodes histologiques quantitatives en pathologie osseuse. Rev. Lyonnaise Méd. 28, 133–142 (1969)

    Google Scholar 

  36. Minaire, P., Meunier, P., Edouard, C., Bernard, J., Courpron, P.: Données histo-morphométriques et biologiques sur l'ostéoporose d'immobilisation. Rev. Rhum. 42 (7–9), 479–488 (1975)

    Google Scholar 

  37. Onino, H.: Effect of calcitonin on the development of immobilization osteoporosis in rat. Endocrinol Jpn. 17, 117–121 (1971)

    Google Scholar 

  38. Rasmussen, H., Bordier, P.: The cellular basis of metabolic bone disease. N. Engl. J. Med. 289, 25–32 (1973)

    Google Scholar 

  39. Rosemeyer, B., Wallner, B.: Changes in bone turnover under immobilization and remobilization. Animal experiments using Ca and Tetracycline labelling. Arch. Orthop. Unfallchir. 83/1, 1–8 (1975)

    Google Scholar 

  40. Schock, C. C., Noyes, F. R., Crouch, M. M., Mathews, C. H. E.: The effects of immobility on long bone remodelling in the Rhesus Monkey. H. Ford Hosp. Med. J. 23/3, 107–116 (1975)

    Google Scholar 

  41. Semb, H.: Experimental disuse osteoporosis. Acta Soc. Med. Upsalieusis 71, 83–107 (1966)

    Google Scholar 

  42. Shashkov, V. S., Kroton, V. P., Volozhin, A. I., Egorov, B., Omitriev, B. S.: Effect of prolonged TCT administration on electrolyte metabolism during normal and restricted movement. Bull. Exp. Biol. Med. 77 (5) 491–493 (1974)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut de Recherche sur les Maladies du Squelette, Institut Calot, 62600, Berck-Plage, France

    R. Duriez & J. Duriez

Authors
  1. R. Duriez
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Duriez
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Duriez, R., Duriez, J. Periosteocyte demineralization in disuse osteoporosis. International Orthopaedics 5, 299–304 (1982). https://doi.org/10.1007/BF00271086

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00271086

Key words

Search

Navigation