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Functional diversity within the rudimentary locus of Drosophila melanogaster

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Summary

The rudimentary locus of Drosophila melanogaster is shown to be at least bifunctional. Mutants in different regions of the locus have either no CPSase or no ATCase activity; some mutants lack both activities. The results are discussed in correlation with the complementation and genetic map of the locus.

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References

  • Anderson, P. M., Meister, A.: Evidence for an activated form of carbon dioxide in the reaction catalyzed by E. coli carbamyl phosphate synthetase. Biochemistry 4, 2803–2806 (1965)

    Google Scholar 

  • Anderson, P. M., Wellner, V. P., Rosenthal, G. A., Meister, A.: Carbamyl phosphate synthetase. In: Methods in enzymology, H. Tabor and C. W. Tabor (eds.), p. 235–243. New York: Academic Press 1970

    Google Scholar 

  • Carlson, P. S.: A genetic analysis of the rudimentary locus of Drosophila melanogaster. Genet. Res. Camb. 17, 63–81 (1971)

    Google Scholar 

  • Davis, R. H., Woodward, V. W.: The relationship between gene suppression and aspartate transcarbamylase activity in pyr-3 mutants of Neurospora. Genetics 47, 1075–1078 (1962)

    Google Scholar 

  • Denis-Duphil, M., Lacroute, F.: Fine structure of the ura 2 locus in Saccharomyces cerevisiae. Molec. gen. Genet. 112, 354–364 (1971).

    Google Scholar 

  • Fahmy, O., Fahmy, M.: Complementation among the sub-genic mutants of the r locus of Drosophila melanogaster. Nature (Lond.) 184, 1927–1929 (1959)

    Google Scholar 

  • Falk, D. R.: Ph. D. Thesis, University of Alberta (1973)

  • Falk, D. R., Nash, D.: The search for auxotrophic mutants in Drosophila melanogaster. In: Insect and mite nutrition, J. G. Rodriguez (ed.), p. 9–31 Amsterdam: North Holland 1972

    Google Scholar 

  • Falk, D. R., Nash, D.: Pyrimidine auxotrophy in Drosophila: normal winged, auxotrophic mutants and dominant auxotrophy. Molec. gen. Genet. (in press) (1974a)

  • Falk, D. R., Nash, D.: Sex-linked auxotrophic and putative auxotrophic mutants of Drosophila melanogaster. Genetics 76, 755–766 (1974b)

    Google Scholar 

  • Gelbart, W. M., McCarron, M., Pandey, J., Chovnick, A.: Genetic limits of the xanthine dehydrogenase structural element within the rosy locus in Drosophila melanogaster. Genetics (in press) (1974)

  • Berhart, J. C., Pardee, A. B.: The enzymology of control by feed back inhibition. J. biol. Chem. 237, 891–894 (1962)

    Google Scholar 

  • Green, M. M.: Interallelic complementation and recombination at the rudimentary wing locus in Drosophila melanogaster. Genetics 34, 242–253 (1963)

    Google Scholar 

  • Jones, M. E.: Regulation of uridylic acid biosynthesis in eucaryotic cells. In: Current topic in cellular regulation, B. L. Horecker and E. R. Stadtman (eds.), p. 227–247. New York: Academic Press 1972

    Google Scholar 

  • Lefevre, G., Jr.: Salivary chromosome bands and the frequency of crossing over in Drosophila melanogaster. Genetics 67, 497–507 (1971)

    Google Scholar 

  • Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, J. R.: Protein measurement with Folin phenol reagent. J. biol. Chem. 193, 265–275 (1951)

    CAS  PubMed  Google Scholar 

  • Lue, P. F., Kaplan, J. G.: Heat-induced disegregation of a multi-functional enzyme complex catalyzing the first step in pyrimidine biosynthesis in baker's yeast. Canad. J. Biochem. 48, 155–159 (1970)

    Google Scholar 

  • Morgan, T. H.: A modification of the sex ratios and other ratios in Drosophila through linkage. Z. indukt. Abstamm.-u. Vererb.-L. 7, 233–235 (1912)

    Google Scholar 

  • Morgan, T. H.: The infertility of rudimentary winged females of Drosophila amyelophila. Amer. Nat. 49, 240–250 (1915)

    Google Scholar 

  • Norby, S.: A specific requirement for pyrimidines in rudimentary mutants of Drosophila melanogaster. Hereditas (Lund) 66, 205–214 (1970)

    Google Scholar 

  • Norby, S.: The biochemical genetics of rudimentary mutants of Drosophila melanogaster. Hereditas (Lund) 73, 11–16 (1973)

    Google Scholar 

  • Norby, S.: The biochemical genetics of rudimentary mutants of Drosophila melanogaster.

  • Shoaf, W. T., Jones, M. E.: Initial step in pyrimidine synthesis in Ehrlich ascites carcinoma. Biochem. biophys. Res. Commun. 45, 796–802 (1971)

    Google Scholar 

  • Tatibana, M., Shigesada, K.: Activation by 5-phosphoribosyl 1-pyrophosphate of glutamine-dependent carbamyl phosphate synthetase from mouse spleen. Biochem. biophys. Res. Commun. 46, 491–497 (1972)

    Google Scholar 

  • Tramell, P. R., Campbell, J. W.: Carbamyl phosphate synthesis in a land snail, Strophocheilus oblongus. J. biol. Chem. 245, 6634–6641 (1970)

    Google Scholar 

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Communicated by E. Hadorn

Supported by National Research Council of Canada, grant A-1764 and National Cancer Institute of Canada, grant 6051 to D. T. Suzuki.

Researcher, Centre National de la Recherche Scientifique, France and recipient of European Molecular Biology Organization Fellowship.

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Jarry, B., Falk, D. Functional diversity within the rudimentary locus of Drosophila melanogaster . Molec. Gen. Genet. 135, 113–122 (1974). https://doi.org/10.1007/BF00264779

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  • DOI: https://doi.org/10.1007/BF00264779

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