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Pharmacokinetics of intravenous cyclophosphamide in man, estimated by gas-liquid chromatography

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  • Pharmacokinetics of Cyclophosphamide
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Summary

A simple gas chromatographic assay utilising alkali flame ionisation detection is described for the estimation of cyclophosphamide as its trifluoroacetate derivative from plasma. Examination of five patients following intravenous cyclophosphamide gave values of 8.9 h (SD 2.7) for the half-life and 0.061 liters/h/kg (SD 0.011) for whole-body clearance of the drug.

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References

  • Bagley, C. M., Bostick, F. W., Vita, V. T. de: Clinical pharmacology of cyclophosphamide. Cancer Res. 33, 226 (1973)

    Google Scholar 

  • Cohen, J. L., Jao, J. Y., Jusko, W. S.: Pharmacokinetics of cyclophosphamide in man. Br. J. Pharmacol. 43, 677 (1971)

    Google Scholar 

  • Fenselau, C., Kan, M.-N. N., Rao, S., Myles, A., Friedman, O. M., Colvin, M.: Identification of aldophosphamide as a metabolite of cyclophosphamide in vitro and in vivo in humans. Cancer Res. 37, 2538 (1977)

    Google Scholar 

  • Gibaldi, M., Perrier, D.: Pharmacokinetics. New York: Dekker 1976

    Google Scholar 

  • Janik, A.: What is the best measure of the detector signal? The peak area or the peak height? J. Chromatogr. Sci. 13, 93 (1975)

    Google Scholar 

  • Jardine, I., Brundrett, R., Colvin, M., Fenselau, C.: Approaches to the pharmacokinetics of cyclophosphamide (NSC-26271): Quantitation of metabolites. Cancer Treat. Rep. 60, 403 (1976)

    Google Scholar 

  • Nelder, J. A., Mead, R.: A simplex method for function minimisation. Computer J. 7, 308 (1965)

    Google Scholar 

  • Norpoth, K., Addicks, H. W., Witting, U.: Quantitative Bestimmungen alkylierender Zytostatika auf der DC-Platte mit 4-Pyridincarboxaldehyd-2-benzothiazolylhydrazon (PBH). Arzneim.-Forsch. 23, 1529 (1973)

    Google Scholar 

  • Pantarotto, C., Bossi, A., Belvedere, G., Martini, A., Donelli, M. G., Frigerio, A.: Quantitative GLC determination of cyclophosphamide and isophosphamide in biological specimens by means of gas chromatography. J. Pharm. Sci. 63, 1554 (1974)

    Google Scholar 

  • Pantarotto, C., Martini, A., Belvedere, G., Donelli, M. G., Frigerio, A.: Studies on the disposition of cyclophosphamide (NSC-26271) in tumor-bearing mice by means of gas chromatography — chemical ionisation — mass fragmentography. Cancer Treat. Rep. 60, 493 (1976)

    Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Guy's Hospital, Medical School, St. Thomas' Street, SE1 9RT, London, England

    F. D. Juma, H. J. Rogers & J. R. Trounce

  2. Department of Forensic Medicine, Guy's Hospital, Medical School, St. Thomas' Street, SE1 9RT, London, England

    I. D. Bradbrook

Authors
  1. F. D. Juma
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  2. H. J. Rogers
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  3. J. R. Trounce
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  4. I. D. Bradbrook
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Juma, F.D., Rogers, H.J., Trounce, J.R. et al. Pharmacokinetics of intravenous cyclophosphamide in man, estimated by gas-liquid chromatography. Cancer Chemother. Pharmacol. 1, 229–231 (1978). https://doi.org/10.1007/BF00257155

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  • DOI: https://doi.org/10.1007/BF00257155

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