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Pharmacokinetics of Intravenously and Intraperitoneally Administered Mafedine Sodium in Mice

  • MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
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Pharmaceutical Chemistry Journal Aims and scope

Peculiarities of the pharmacokinetics of mafedine sodium salt upon intraperitoneal (i.p.) and intravenous (i.v.) administration to laboratory mice were studied. A high-performance liquid chromatography (HPLC) method for its quantitative determination was proposed. Mafedine sodium salt was found to have a short biological elimination half-life after both i.p. and i.v. administration (15.73 and 6.98 min, respectively) and high i.p. bioavailability (~94%). Features of the alpha-2-adrenomimetic activity of mafedine sodium salt could be elucidated by further searches for and investigations of its metabolites and their pharmacokinetics.

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Authors and Affiliations

  1. N. P. Bechtereva Institute of the Human Brain, Russian Academy of Sciences, 9 Akad. Pavlova St., St. Petersburg, 197376, Russia

    Yu. I. Sysoev, V. A. Prikhodko, E. D. Semivelichenko, E. I. Eletskaya & S. V. Okovityi

  2. St. Petersburg State Chemical and Pharmaceutical University, Ministry of Health of the Russian Federation, 14/A Prof. Popova St., St. Petersburg, 197376, Russia

    Yu. I. Sysoev, A. K. Whaley, V. A. Prikhodko, E. D. Semivelichenko, E. I. Eletskaya, V. G. Luzhanin & S. V. Okovityi

  3. Institute of Translational Biomedicine, St. Petersburg State University, 7 – 9 Universitetskaya Nab., Room 1050, St. Petersburg, 199034, Russia

    Yu. I. Sysoev

Authors
  1. Yu. I. Sysoev
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  2. A. K. Whaley
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  3. V. A. Prikhodko
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  4. E. D. Semivelichenko
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  5. E. I. Eletskaya
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  6. V. G. Luzhanin
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  7. S. V. Okovityi
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Corresponding author

Correspondence to V. A. Prikhodko.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 12, pp. 3 – 7, December, 2020.

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Sysoev, Y.I., Whaley, A.K., Prikhodko, V.A. et al. Pharmacokinetics of Intravenously and Intraperitoneally Administered Mafedine Sodium in Mice. Pharm Chem J 54, 1193–1197 (2021). https://doi.org/10.1007/s11094-021-02342-y

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  • DOI: https://doi.org/10.1007/s11094-021-02342-y

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