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Myocardial scintigraphy — 25 years after start

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Abstract

The development of myocardial scintigraphy (MS) reflects the clinical success of a representative procedure in nuclear medicine. Radiopharmaceuticals for visualizing vital and damaged myocardium and techniques (planar-qualitative, planar-quantitative, SPECT-qualitative — quantitative with comparative sensitivities) are briefly reviewed with the main focus on their clinical application in coronary (CHD) and noncoronary heart disease, where recent literature from the United States and Europe is considered. The limited value of MS for screening of CHD is outlined and its present and future role in detecting asymptomatic (silent) ischemia/infarction and asymptomatic patients at professional risk is stressed. The present state of MS in coronary heart disease is discussed for single and multivessel disease, previous infarction, and risk stratification (myocardial washout, pulmonary uptake, ischemic dilation, absent heart sign), reflecting the importance of the procedure in exercise-induced ischemia as well as in ischemia at rest for prognostication of the natural and therapeutic course, i.e., therapy control (angioplasty, bypass, lysis, cardiac drugs). More marginal but upcoming clinical indications are mentioned, such as progressive systemic sclerosis, cardiac transplantation, pediatric cardiology, and problems of nephrology/urology. The “normal” values and the impact of digital radiology and of contrast cardiography are touched upon. Preliminary cases with 111In-antimyosin and 99mTc-Isonitriles are presented including correlative results between global ejection fraction determination according to gated 99mTc-isonitrile and conventional 99mTc-erythrocyte ventriculogram (r=0,75; n=10).

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References

  • Abenavoli T, Rubler S, Fisher VJ, Axelrod HI, Zuckerman KP (1981) Exercise testing with myocardial scintigraphy in asymptomatic diabetic males. Circulation 63:54–64

    Google Scholar 

  • Akins CW, Pohost GM, Desanctis RW, Block PC (1980) Selection of angina free patients with severe left ventricular dysfunction for myocardial revascularization. Am J Cardiol 46:695

    Google Scholar 

  • American College of Cardiology/American Heart Association Task Force Ass. Cardiovasc. Proc. (1986) Guidelines for clinical use of cardiac radionuclide imaging. Circulation 74:1469A-1482A

    Google Scholar 

  • Amor M, Balaud A, Karcher G, Ethevenot G (1984) Diagnosis of chronic coronary insufficiency by stress single photon emission tomography. In: Schmidt HAE, Vauramo DE (eds) Nuklearmedizin. FK Schattauer, Stuttgart, p 123

    Google Scholar 

  • Atwood JE, Jenson D, Froelicher V (1981) Agreement in human interpretation of analogue thallium myocardial perfusion images. Circulation 64:601–609

    Google Scholar 

  • Ballard FB, Danforth WH, Naegele S (1960) Myocardial metabolism of fatty acids. J Clin Invest 39:717

    Google Scholar 

  • Bateman TM, Maddahi J, Gray RJ (1984) Diffuse slow washout of myocardial thallium 201: A new scintigraphic indicator of extensive coronary artery disease. J Am Coll Cardiol 4:55–64

    Google Scholar 

  • Bähre M, Neumann GP, Grouls V (1979) Myokardszintigraphie mit Tl-201 bei Angiosarkom des Herzens. Nuc Comp 10:86–88

    Google Scholar 

  • Bailey IK, Come PC, Kelly DT (1977) Thallium-201 myocardial perfusion imaging in aortic valve stenosis. Am J Cardiol 40:889

    Google Scholar 

  • Becker W, Borst U, Maisch B, Epping I, Börner W, Kochsiek K (1987a) Localization of inflammatory heart disease by In-111-labeled granulocytes. In: Schmidt HAE, Emrich D (eds) Nuklearmedizin. FK Schattauer, Stuttgart New York, p 60

    Google Scholar 

  • Bellamy GR, Yannikas J, Detrano R, Simpfendorfer C, Salcedo EE (1986) Detection of multivessel disease after myocardial infarction using intravenous stress digital subtraction angiography. Radiology 161:685–689

    Google Scholar 

  • Benjelloun H, Itti R, Logeron JM, Charbonnier B, Brochier M (1983) Negative lung thallium uptake in right ventricular infarction. Eur J Nucl Med 8:99–100

    Google Scholar 

  • Berger BC, Watson DD, Burwell LR, Crosby IK, Wellons HA, Teates CHD, Beller GA (1979) Redistribution of thallium at rest in patients with stable and unstable angina and the effect of coronary artery bypass surgery. Circulation 60:114–1125

    Google Scholar 

  • Bergman STR, Lerch RA, Mathias CJ, Sobel BE, Welch MJ (1983) Noninvasive detection of coronary thrombi with In-111 platelets: Concise communication. J Nucl Med 14:130–135

    Google Scholar 

  • Berman DS, Mason DT (1981) Clinical nuclear cardiology. Grune and Stratton, New York London

    Google Scholar 

  • Bingham JB, Straus HW, Pohost GM (1978) Mechanism of lung uptake of thallium-201 (abstr). Circulation 57/58 (Suppl II)

  • Botsch H (1987) Myocardscintigraphie. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Boucher CHA, Zir LM, Beller GA, Kenneth R (1980) Increased lung uptake of thallium 201 during exercise myocardial imaging and angiographic implications in patients with coronary artery disease. Am J Cardiol 46:189–196

    Google Scholar 

  • Boucher CHA, Brewster DC, Darling RC (1985) Determination of cardiac risk by dipyridamol-thallium imaging before peripheral vascular surgery. N Engl J Med 312:389–394

    Google Scholar 

  • Bourguignon MH, Valette H, Le Guludec D, Pauwels EKJ (1987) Evaluation of 3 dimensional space and time filtering on ECG gated 201-Tl-myocardial images. Eur J Nucl Med 13:278–282

    Google Scholar 

  • Brachman MB, Rozanski A, Charuzi Y (1981) Thallium-201 stress redistribution abnormalities of the right ventricle: A manifestation of proximal right coronary artery stenosis. Am Heart J 101:288–291

    Google Scholar 

  • Brown KA, Boucher CHA, Okada RD (1983) Prognostic value of exercise thallium-201 imaging in patients presenting for evaluation of chest pain. J Am Coll Cardiol 1:994–1001

    Google Scholar 

  • Brown KA, Benoit L, Clements JP, Wackers FJTH (1987) Fast washout of thallium-201 from area of myocardial infarction: Possible artifact of background subtraction. J Nucl Med 28:945–949

    Google Scholar 

  • Büll U, Strauer BE (1980) Wertigkeit nuklearmedizinischer Verfahren in der Diagnostik des akuten Myokardinfarktes. Internist 21:667–674

    Google Scholar 

  • Büll U, Strauer BE (1981) Assessment of left ventricular muscle mass with thallium 201 myocardial imaging. In: Strauer BE (ed) The heart in hypertension, Springer, Berlin Heidelberg New York, p 345

    Google Scholar 

  • Büll U, Strauer BE, Bürger S, Witte J, Niendorf HP (1978) Effects of physical stress and pharmacologically induced coronary dilation on myocardial and non-myocardial thallium 201 uptake. Eur J Nucl Med 3:19–27

    Google Scholar 

  • Büll U, Kirsch CM, Höfling B, Roedler HD (1986) Ergebnisse der 201 Thallium-SPECT des Myokards zur Erfassung der koronaren Herzkrankheit und zur Verlaufskontrolle bei perkutaner transluminaler koronarer Angioplastik. Nucl Med 25:71–77

    Google Scholar 

  • Büll U, Stirner H, vom Dahl J, Uebis R (1987) Quantitative evaluation of myocardial stress/rest Tl-201 SPECT: Results of a ROI-based method in 108 patients with CHD. Nucl Med 26:234–240

    Google Scholar 

  • Bureau JF, Gaillard JF, Granier R, Ollivier JP (1987) Diagnostic and prognostic criteria of chronic left ventricular failure obtained during exercise-201 Tl-imaging. Eur J Nucl Med 12:613–616

    Google Scholar 

  • Caldwell JH, Williams DL, Hamilton GW (1982) Regional distribution of myocardial blood flow measured by SPECT: Comparison with in vitro counting. J Nucl Med 23:490–495

    Google Scholar 

  • Caldwell JH, Williams DL, Harper GD (1984) Quantitation of size of relative myocardial perfusion defect by SPECT. Circulation 70:1048–1056

    Google Scholar 

  • Campbell S, Holman B, Kirshenbaum J (1986) The scintigraphic evaluation of myocardial infarction and regional ventricular performance using technetium-99m hexakis (t-butylisonitrile) technetium I (TBI): A new myocardial imaging agent. Eur J Nucl Med 12:219–225

    Google Scholar 

  • Canhasi B, Dae M, Botvinick E (1985) Interaction of “supplementary” scintigraphic indicators of ischemia and stress electrocardiography in the diagnosis of multivessel coronary disease. J Am Coll Cardiol 6:581–588

    Google Scholar 

  • Carr E, Beierwaltes WH, Patno ME (1962) The detection of experimental myocardial infarcts by photoscanning. Am Heart J 64:650

    Google Scholar 

  • Cinotti L, Meignan M, Usdin JP, Vasile N, Castaigne A (1983) Diagnostic value of image processing in myocardial scintigraphy. J Nucl Med 24:768–774

    Google Scholar 

  • Cogswell TL, Sagar KB, Wann LS (1987) Echocardiographic evaluation of cardiac function during exercise. In: Pohost GM, Higgins CHB, Morganroth J, Ritchie JL, Schelbert HR (eds) New concepts in cardiac imaging 1987. Year Book Medical Publ., Chicago London, p 13

    Google Scholar 

  • Cohen HA, Baird MG, Rouleau JR, Fuhrmann CF (1976) Thallium 201 myocardial imaging in patients with pulmonary hypertension. Circulation 54:790–795

    Google Scholar 

  • Cohn PF (1977) Severe asymptomatic coronary artery disease—A diagnostic, prognostic and therapeutic puzzle. Am J Med 62:565–568

    Google Scholar 

  • Cox PH (1976) Thallium 201-chloride uptake in tumours, a possible complication in heart scintigraphy. Br J Radiol 49:767

    Google Scholar 

  • Creutzig H, Creutzig A (1985) Kardiale und periphere Perfusionsstörungen. In: Hör G, Kaltenbach M, Maul FD, Pabst HW (eds) Interventionelle Nuklearkardiologie. Kern und Birner, Frankfurt/M, p 23

    Google Scholar 

  • Dash H, Massie BM, Botvinick EH, Brundage BH (1979) The noninvasive identification of left main and three-vessel coronary artery disease by myocardial stress perfusion scintigraphy and treadmill exercise electrocardiography. Circulation 60:276–283

    Google Scholar 

  • Daspit SG, Stemple DR, Doherty PW, Goris ML (1977) Unusual findings in 201-Tl myocardium scintigraphy: The “hot heart” sign. Clin Nucl Med 2:1–5

    Google Scholar 

  • Detry JMR, Melin JA, Derwael-Barchy C, D'Hondt AM (1984) Role of exercise testing and stress thallium scintigraphy in the management of old men with suspected or documented coronary artery disease. Eur Heart J 5 (Suppl E):75–77

    Google Scholar 

  • Deutsch E, Glavan KA, Sodd WJ, Nishiyama H, Ferguson DL, Lukes STJ (1981) Cationic Tc-99m complexes as potential myocardial imaging agent. J Nucl Med 22:897–907

    Google Scholar 

  • Doherty PW, Lipton MJ, Berninger WH, Skioldebrand CG, Carlsson E, Redington RW (1981) Detection and quantitation of myocardial infarction in vivo using transmission computed tomography. Circulation 63:597–606

    Google Scholar 

  • Dreyfuss F, Ben-Porath M, Menczel J (1960) Radioiodine uptake by the infarcted heart. Am J Cardiol Aug:237–245

  • Dudzak R, Lenzhofer R, Kletter K (1985) Indication of doxorubicin induced impairtmet in fatty acid utilization. J Nucl Med (abstr) 26:829

    Google Scholar 

  • Dunn RF, Freedman B, Balley IK (1980) Exercise thallium imaging: Location of perfusion abnormalities in single coronary artery disease. J Nucl Med 21:717–722

    Google Scholar 

  • Dunn RF, Wolff L, Wagner S, Botvinivk EH (1981) The inconsistent pattern of thallium defects—A clue to the false positive scintigram. Am J Cardiol 48:224–233

    Google Scholar 

  • Dunn RF, Uren RF, Sadick N (1982) Comparison of thallium-201 scanning in idiopathic dilated cardiomyopathy and severe coronary artery disease. Circulation 66:804–810

    Google Scholar 

  • Duska F, Nesvadba Z, Zdansky P, Novak J, Kubicek J, Kafka P, Vizda J, Mazurova Y (1984) The pyrophosphate heart scintigram in children with progressive muscular dystrophy. Nucl Med 23:189–191

    Google Scholar 

  • Eichstädt H (1984) Quantitative Myokardszintigraphie bei Koronaroperationen. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Eichstädt H, Krämer R, Dougherty FCH, Schneider R, Felix R, Schmutzler H (1983) Darstellung von Hypertrophieregression unter chronischer Betablockade mit Hilfe der quantitativen Schichtszintigraphie. Z Kardiol Suppl Abstr No 183

  • Eisen HJ, Eisenberg STB, Saffitz JE, Bolman RM (1987) Noninvasive detection of rejection of transplanted hearts with 111 Inlabeled lymphocytes. Circulation 75:868–876

    Google Scholar 

  • Eißner D von, Olshausen K, Hahn K (1986) Long term results of percutaneous transluminal coronary angioplasty documented by thallium-201 exercise scintigraphy. In: Schmidt HAE, Ell PJ, Britton KE (eds) Nuklearmedizin, FK Schattauer, Stuttgart New York, p 58

    Google Scholar 

  • Evans JR, Gunton RW, Baker RG, Beanlands DS, Spears JC (1965) Use of radioiodinated fatty acid for photoscans of heart. Circ Res 16:1

    Google Scholar 

  • Feinendegen LE, Vyska K, Freundlieb CHR, Höck A, Machulla HJ, Kloster G, Stöcklin G (1981) Non-invasive analysis of metabolic reactions in body tissues, the case of myocardial fatty acids. Eur J Nucl Med 6:191–200

    Google Scholar 

  • Feinendegen LE, Höck A, Spohr G (1985) Therapeutische Intervention: Myokardmetabolismus. In: Hör G, Kaltenbach M, Maul FD, Pabst HW (eds) Interventionelle Nuklearkardiologie. Kern und Birner, Frankfurt, p 346

    Google Scholar 

  • Follansbee WP, Curtiss EII, Medsger THA, Owens GR, Steen VD, Rodnan GP (1984) Myocardial function and perfusion in the CREST-syndrome variant of progressive systemic sclerosis. Am J Med 77:489–496

    Google Scholar 

  • Freeman LM, Blaufox MD (eds) (1987) Single photon emission computed tomography. Semin Nucl Med 17:183–275

  • Froelicher VF, Brown PH (1981) Exercise and coronary heart disease. J Cardiac Rehabil 4:277–288

    Google Scholar 

  • Funke-Küpper AJ, Verheugt FWA, Jaarsam W (1986) Detection of ventricular thrombosis in acute myocardial infarction: Value of indium-111 platelet scintigraphy in relation of two-dimensional echocardiography and clinical course. Eur J Nucl Med 12:337–341

    Google Scholar 

  • Fuster V, Dewanjee MK, Kaye MP (1979) Noninvasive radioisotopic technique for detection of platelet deposition in coronary artery bypass grafts in dogs and its reduction with platelets inhibitors. Circulation 60:1508

    Google Scholar 

  • Gaffney FA, Wohl AI, Blomquist CG, Parkey RW, Willerson JT (1978) Thallium-201 myocardial perfusion studies in patients with mitral valve prolapse syndrome. Am J Med 64:21–26

    Google Scholar 

  • Gammage MD, Murray DP, Rafiqui E, Murray RG (1986) The clinical role of thallium-201 scintigraphy in the management and prognosis of coronary artery disease. Eur Heart J 7:412–417

    Google Scholar 

  • Garcia EV, van Train K, Maddahi J (1985) Quantification of rotational thallium-201 myocardial tomography. J Nucl Med 26:17–26

    Google Scholar 

  • Gasic S, Dudzak R, Korn A, Kletter K (1980) Beeinflussung der Thallium-201-Myokardperfusion unter Belastung bei Patienten mit koronarer Herzkrankheit durch den Kalziumantagonisten Dimeditiapramamin(Ro-11-1781). Wien Klin Wochenschr 92:284

    Google Scholar 

  • Gelber CM, Diskin CJ, Claunch BC (1984) Thallium myocardial imaging in patients with chronic hemodialysis. Nephron 36:136–142

    Google Scholar 

  • Gewirtz H, Beller GA, Strauss HW, Dismore RE, Zir LM, McKusick KA, Pohost GM (1979) Transient defects of resting thallium scans in patients with coronary artery disease. Circulation 59:707

    Google Scholar 

  • Gibson RS, Taylor GT, Watson DD (1980) Prognostic significance of resting anterior thallium-201 defects in patients with inferior myocardial infarction. J Nucl Med 21:1015–1021

    Google Scholar 

  • Gibson RS, Watson DD, Craddock GB (1983) Prediction of cardiac events after uncomplicated myocardial infarction: A prospective study comparing predischarge exercise-thallium-201 scintigraphy and coronary angiography. Circulation 68:321–336

    CAS  PubMed  Google Scholar 

  • Gilday DL (1981) Static myocardial scintigraphy in pediatrics. In: Hör G, Felix R (eds) Kardiovaskuläre Nuklearmedizin. Schnetztor, Konstanz, p 141–150

    Google Scholar 

  • Giles R, Hoffer P, Lange R, Zaret B, Wackers F (1982) Serial alternating assessment of ventricular performance and myocardial perfusion using gold-195 m and thallium 201. J Nucl Med 23:P80

    Google Scholar 

  • Gitler B, Fishbach M, Steingart RM (1984) Use of electrocardiographic thallium exercise testing in clinical practice. J Am Coll Cardiol 21:262–271

    Google Scholar 

  • Goldstein RA, Klein MS, Sobel BE (1980) Detection of myocardial ischemia before infarction based on accumulation of labelled pyruvate. J Nucl Med 21:1101

    Google Scholar 

  • Goldstein RA, Kirkeeide RL, Smalling RW, Nishikawa A (1987) Changes in myocardial perfusion reserve after PTCA: Noninvasive assessment with positron tomography. J Nucl Med 28:1262–1267

    Google Scholar 

  • Golitsin A, Pinedo JI, Cienfuegos JA, Chamorro JL, Ortitz-Berrocal J, Castillo-Ovarez JL (1984) Thallium-201-uptake: A useful method for assessing heart transplantation. Transplant Proc 16:1262–1264

    Google Scholar 

  • Gottlieb SO, Weisfeldt ML, Ouyang P (1986) Silent ischemia as a marker for early unfavorable outcomes in patients with unstable angina. N Engl J Med 314:1214–1219

    Google Scholar 

  • Gould KL (1987) Pharmacological intervention as an alternative to exercise studies. Semin Nucl Med 17:121–130

    Google Scholar 

  • Grenz R, Maul FD, Standke R, Klepzig H Jr, Kober G, Hör G (1986) Ergebnisse der kombinierten Myokardszintigraphie und Radionuklidventrikulographie vor und nach transluminaler Koronarangioplastik kritischer Koronararterienstenosen. Nucl Med 25:106–113

    Google Scholar 

  • Grover-McKay M, Froelicher VF (1987) A new hihgly specific thallium-201 marker for severe and extensive coronary artery disease. J Am Coll Cardiol 9:760–762

    Google Scholar 

  • Haber E, Yasuda T, Palacios IF, Dec GW, Golg HK (1986) Antibody imaging in the diagnosis of acute myocarditis. Eur Heart (Suppl E) J 7

  • Hakki AH, Iskandrian AS, Segal BL, Kane SA (1981) Use of exercise thallium scintigraphy to assess extent of ischemic myocardium in patients with left anterior descending artery disease. Br Heart J 45:703–709

    Google Scholar 

  • Halama JR, Henkin RE (1987) Quality assurance in SPECT imaging. Appl Radiol 16:41–50

    Google Scholar 

  • Hall TS, Baumgartner WA, Borkon M (1986) Diagnosis of acute cardiac rejection with antimyosin monoclonal antibody, phosphorus nuclear magnetic resonance imaging, two-dimensional echocardiography and endocardial biopsy. J Heart Transplant 5:419–424

    Google Scholar 

  • Herrmann G, Simon R, Lichtlen PR (1986) Eingefäßerkrankung des Ramus interventricularis anterior eines kombinierten Vorder- und Hinterwandinfarktes im Vergleich zur Zweigefäß-erkrankung des RIVA und der RCA. Z Kardiol 75:334–341

    Google Scholar 

  • Hockings B, Saltissi S, Croft DN, Webb-Peploe N (1983) Effect of beta adrenergic blockade on thallium-201 myocardial perfusion imaging. Br Heart J 49:83–89

    Google Scholar 

  • Höck A, Freundlieb CHR, Vyska K, Lösse B, Erbel R, Feinendegen LE (1983) Myocardial imaging and metabolic studies with (17-I-123)iodoheptadecanoic acid in patients with idiopathic congestive cardiomyopathy. J Nucl Med 24:22–28

    Google Scholar 

  • Höck A, Notohamiprodjo G, Spohr G, Kaiser KP (1986) Myocardial fatty acid metabolism after acute ethanol consumption. Nucl Med Commun 7:671–682

    Google Scholar 

  • Hör G, Baum RP (1987) Myocardial perfusion, In: Pabst HW, Adam WE, Hör G, Kriegel H (eds) Textbook of nuclear medicine, Fischer, Stuttgart New York (in press)

    Google Scholar 

  • Hör G, Bussmann WD (eds) (1984) kardiovaskuläre Nuklearmedizin (Ambulanz und Intensivstation). Fischer, Stuttgart New York

    Google Scholar 

  • Hör G, Bussmann WD (1985) Myokardszintigraphie in der Diagnostik des Myokardinfarktes. Inn Med 12:159–165

    Google Scholar 

  • Hör G, Kanemoto N (1981) 201-Thallium myocardial scintigraphy: Current status in coronary artery disease, results of sensitivity/specificity in 3092 patients and clinical recommendations. Nucl Med 20:136–147

    Google Scholar 

  • Hör G, Klepzig H Jr (1987a) Herz. In: Büll U, Hör G (eds) Klinische Nuklearmedizin. VCH, Weinheim, p 139–154

    Google Scholar 

  • Hör G, Klepzig H Jr (1987b) Myocardial scintigraphy with 201 Tl: II. Clinical Applications (Coronary Heart Disease). Nucl Med 26:297/155–200/158

    Google Scholar 

  • Hör G, Maul FD (1985) Beitrag der Myokardszintigraphie in der Therapiekontrolle (Gegenwärtiger Stand und Ausblick). Z Kardiol 74:65–75

    Google Scholar 

  • Hör G, Lichte H, Pabst HW, Luther M (1974) 201-Thallium-Myokardszintigraphie bei Herzinfarkt. Nucl Comp 5:77–82

    Google Scholar 

  • Hör G, Sebening H, Sauer E, Dressler J, Lutilsky L, Wagner-Manslau C, Bofilias I, Wolf I, Pabst HW (1979) 201-thallium-redistribution analysis in early and delayed myocardial scintigrams of patients with coronary heart disease (CHD). Eur J Nucl Med 4:343–350

    Google Scholar 

  • Hör G, Kanemoto N, Standke R, Maul FD, Klepzig H Jr, Kober G, Kaltenbach M (1980) Transluminale Angioplastik: Erfolgskontrolle durch Verfahren der Nuklearmedizin nach nichtoperativer Dilatation kritischer Koronararterienstenosen. Herz 5:168–176

    Google Scholar 

  • Hör G, Maul FD, Standke R, Grossmann R (1985) Transluminale Koronarangioplastik: Nuklearmedizinische Ergebnisse. In: Hör G, Kaltenbach M, Maul FD, Pabst HW (eds) Interventionelle Nuklearkardiologie. Kern und Birner, Frankfurt/Main, p 14

    Google Scholar 

  • Hör G, Kober G, Maul FD, Klepzig H Jr, Standke R, Bittner G, Kanemoto N, Happ J, Baum RP (1987a) Nuclear cardiology results before and after percutaneous transluminal coronary angioplasty (PTCA): 1978–1986. Nucl Med Commun 8:127–137

    Google Scholar 

  • Hör G, Maul FD, Standke R, Bittner G (1987b) Gated myocardial scintigraphy with Tc-99m-isonitrile (“MIBI”) in previous myocardial infarction: Preliminary results of a one-step procedure for perfusion and function (submitted)

  • Holman BL, Hill TC, Wynne J, Lovett RD, Zimmermann RE, Smith EM (1979) Single photon transaxial emission computed tomography of the heart in normal subjects and in patients with infarctions. J Nucl Med 20:736–740

    Google Scholar 

  • Holman BL, Campbell CA, Lister-James J, Jones AG, Davison A, Kloner RA (1986) Effect of reperfusion and hyperemia on the myocardial distribution of technetium-99m t-butyl-isonitrile. J Nucl Med 127:1172–1177

    Google Scholar 

  • Hosenpud JD, Montanaro A, Hart MV (1984) Myocardial perfusion abnormalities in asymptomatic patients with systemic lupus erythematosus. Am J Med 77:286–292

    Google Scholar 

  • Hung J, Goris ML, Nash E (1984) Comparative value of maximal treadmill testing, exercise thallium myocardial perfusion scintigraphy and exercise radionuclide ventriculography for distinguishing high and low risk patients soon after acute myocardial infarction. Am J Cardiol 53:1221–1227

    Google Scholar 

  • Iskandrian AS, Haaz W, Segal BL, Kane SA (1981) Exercise thallium-201 scintigraphy in evaluating aortocoronary surgery. Chest 80:11–16

    Google Scholar 

  • Iskandrian AS, Hakki AH, Kane-Marsch S (1985) Prognostic implications of exercise thallium-201 scintigraphy in patients with suspected or known coronary artery disease. Am Heart J 110:135–143

    Google Scholar 

  • Johnston DL, Rockey R, Okada RD (1987) Nuclear magnetic resonance imaging of the cardiovascular system. Herz 12:51–67

    Google Scholar 

  • Jones AG, Davison M, Abrams MJ (1982) Investigations on a new class of technetium cations. J Nucl Med 23:P16

    Google Scholar 

  • Kalff V, Kelly MJ, Soward A (1985) Assessment of hemodynamic significance of isolated stenoses of the left anterior descending coronary artery using thallium-201-myocardial scintigraphy. Am J Cardiol 55:34–346

    Google Scholar 

  • Kambara H, Ishii Y, Kadota K, Yonekura Y (1980) Thallium-201 myocardial scintigraphy: Fractional uptake by the myocardium at rest and during exercise in patients with coronary artery disease and hypertrophic cardiomyopathy. Eur J Nucl Med 5:493–498

    Google Scholar 

  • Karcher G, Bertrand A, Amor M, Ballaud A (1986) Assessment of residual myocardial ischemia after myocardial infarction by thallium scintigraphy. In: Schmidt HAE, Ell PJ, Britton KE (eds) Nuklearmedizin. FK Schattauer, Stuttgart New York, p 67

    Google Scholar 

  • Kataoka H, Tabuchi H, Ohkubo T, Takaoka S (1987) Analysis of papillary muscle images on planar thallium-201 myocardia scintigrams in various heart diseases. Eur J Nucl Med 13:143–147

    Google Scholar 

  • Kaul S, Kiess M, Liu P (1985) Comparison of exercise electrocardiography and quantitative thallium imaging for single vessel coronary artery disease. Am J Cardiol 56:257

    Google Scholar 

  • Kaul S, Boucher CA, Newell JB (1986a) Determination of the quantitative thallium imaging variables that optimize detection of coronary artery disease. J Am Coll Cardiol 7:527

    Google Scholar 

  • Kaul S, Newell JB, Chesler DA, Pohost GM, Okada RA, Boucher CHAA (1986b) Quantitative thallium imaging findings in patients with normal coronary angiographic findings and in clinically normal subjects. Am J Cardiol 57:509–512

    Google Scholar 

  • Kaul S, Chesler DA, Boucher CHA, Okada RD (1987) Quantitative aspects of myocardial perfusion imaging. Semin Nucl Med 17:131–144

    Google Scholar 

  • Keyes JW Jr, Orlandea N, Heetdercks WJ (1977) The humogotron: A scintillation camera transaxial tomography. J Nucl Med 18:381–387

    Google Scholar 

  • Khaw BA, Fallon JT, Russel PS (1981) New approach to determination of heart transplant rejection by 125-I-antimyosin and Tc-99m fibrinogen (abstr). Clin Res 29:496A

    Google Scholar 

  • Khaw BA, Straus HW, Moore R, Fallon JT, Yasuda T, Gold HK, Haber E (1987) Myocardial damage delineated by indium-111 antimyosin fab and technetium-99m pyrophosphate. J Nucl Med 28:76–82

    Google Scholar 

  • Kinney EL, Jackson GL, Reeves GC, Zelis R, Beers E (1980) Thallium scan myocardial defects and echocardiographic abnormalities in patients with sarcoidosis without clinical cardiac dysfunction. Am J Med 68:497–503

    Google Scholar 

  • Kirsch CM, Doliwa R, Büll U, Hoefling B (1985) Sensitivität und Spezifität von Belastungsuntersuchungen des Herzens mit Tl-201 in SPECT-Technik. Nuklearmediziner 8:241–249

    Google Scholar 

  • Kleinman B, Henkin RE, Glisson SN, El-Etr AA, Bakhos M, Sullivan HJ, Montoya A, Pifarre R (1986) Qualitative evaluation of coronary flow during anesthetic induction using thallium-201 perfusion scans. Anesthesiology 64:157–164

    Google Scholar 

  • Klepzig H Jr, Kaltenbach M (1985) Stufendiagnostik der koronaren Herzdiagnostik. Intern Welt 6:19–26

    Google Scholar 

  • Kober G, Grossmann R, Tauer HM, Scherer D (1984) Silent myocardial ischemia deduced from improved left ventricular function after coronary angioplasty. In: Rutishauser W, Roskamm H (eds) Silent myocardial ischemia. Springer, Berlin Heidelberg New York, p 58

    Google Scholar 

  • Köhn H, Frohner K, Bialonczyk C, Unger G, Mostbeck A, Steinbach K (1984) Intravenous streptokinase therapy in acute myocardial infarction: Assessment of therapy effects by quantitative Tl-201 imaging (including SPECT) and radionuclide ventriculography. Eur J Nucl Med 9:408–412

    Google Scholar 

  • Kondo M, Kubo A, Yamazaki H, Ohsuzu F, Handa S, Tsugu T, Masaki H, Kinoshita F, Hashimoto S (1978) Thallium 201 myocardial imaging for evaluation of right ventricular overloading. J Nucl Med 19:1197–1200

    Google Scholar 

  • Koskinen M, Pöyhönen L, Seppänen S (1987) Thallium-201 washout in coronary artery disease using SPECT — a comparison with coronary angiography. Eur J Nucl Med 12:609–612

    Google Scholar 

  • Koss JH, Kobren STM, Grunwald AM, Bodenheimer MM (1987) Role of exercise thallium-201 myocardial perfusion scintigraphy in predicting prognosis in suspected coronary artery disease. Am J Cardiol 59:531–534

    Google Scholar 

  • Kotler J, Trobaugh GB, Williams DL, Gustafson DE, Tutt RC (1982) Demonstration of a right ventricular infarction with tomographic thallium myocardial imaging. J Nucl Med 23:1111–1113

    Google Scholar 

  • Ladenheim ML, Pollack BH, Rozanski A (1986) Extent and severity of myocardial hypoperfusion as orthogonal indices of prognosis in patients with suspected coronary artery disease. J Am Coll Cardiol 7:464–471

    Google Scholar 

  • La France MD, Fracier C, Ravert H, Cole P, Borkon M, Baumgartner W, Reitz B, Wagner HN Jr (1987) In-111-antimyosin monoclonal antibody (AMAb) in detecting rejection of cyclosporin treated heart transplantation. J Nucl Med 28:663 (abstr no 443)

    Google Scholar 

  • Laird EE, Rajathurai A, Williams ED, Mittra B, Rankin D (1984) Quantitative analysis of rotating gamma camera thallium-201 scintigrams of myocardium. Nucl Med Commun 5:577–586

    Google Scholar 

  • Lebowitz E, Greene MW, Fairchild R, Bradley-Moore PR, Atkins HL, Ansari AN, Richards P, Belgrave E (1975) Thallium for medical use I. J Nucl Med 16:151–155

    Google Scholar 

  • Lees RS, Garabedian HD, Lees AM, Schumacher DJ, Miller A, Isaacsoh JL, Derksen A, Strauss HW (1985) Technetium 99m low density lipoproteins: Preparation and biodistribution. J Nucl Med 26:1056–1062

    Google Scholar 

  • Leonard JC, Raftery RG (1985) Metastatic osteogenic sarcoma involving the left ventricle. Identification with gallium-67. Clin Nucl Med 10:440

    Google Scholar 

  • Leppo J, Yipintsoi T, Blankenstein R (1979) Thallium-201 myocardial scintigraphy in patients with triple vessel disease and ischemic exercise stress tests. Circulation 59:714–721

    Google Scholar 

  • Leppo JA, O'Brien J, Rothendler JA (1984) Dipyridamol-thallium scintigraphy in the prediction of future cardiac events after myocardial infarction. N Engl J Med 310:1014–1018

    Google Scholar 

  • Levy R, Rozanski A, Berman DS (1983) Analysis of the degree of the pulmonary thallium wash-out after exercise in patients with coronary artery disease. J Am Coll Cardiol 2:719–728

    Google Scholar 

  • Liu P, Kiess M, Okada RD (1985) Increased thallium lung uptake after exercise in isolated left anterior decending coronary artery disease. Am J Cardiol 55:1469–1473

    Google Scholar 

  • Löllgen H, Ulmer HV (1985) Ergometrie-Empfehlungen zur Durchführungen und Bewertung ergometrischer Untersuchungen. Klin Wochenschr 63:651–677

    Google Scholar 

  • Lösse B, Kroenert H, Rafflenbeul D (1979) Empfindlichkeit und Treffsicherheit der Thallium-201-Myokardszintigraphie bei der Diagnostik der koronaren Herzkrankheit und von Myokardschäden anderer Ursache. Z Kardiol 68:429–435

    Google Scholar 

  • Maddahi J, Abdulla A, Gracia EV, Swan HJC, Berman DS (1986) Noninvasive identification of left main and triple vessel coronary artery disease: Improved accuracy using quantitative analysis of regional myocardial stress distribution and wash-out of thallium 201. J Am Coll Cardiol 7:53–60

    Google Scholar 

  • Mathey D, Montz R, Hanrath P, Knop J, Kupper W, Schneider C, Bleifeld W (1978) Kurzfristige regionale Myokardischämie und ihre Folgen bei Prinzmetal-Angina. Dtsch Med Wochenschr 103:969–971

    Google Scholar 

  • Maublant J, Cassagnes J, Jourde M, Veyre A, Meyniel G (1981) Myocardial emission tomography with thallium-201. Eur J Nucl Med 6:289–294

    Google Scholar 

  • Maul FD, Hör G, Standke R Kober G (1985) Anforderungen an die ergometrische Myokardzintigraphie mit Thallium-201 vor und nach Koronarrevaskularisation am Beispiel der transluminalen Angioplastik. Nuklearmediziner 8:251–263

    Google Scholar 

  • McKillop JH, Billingham M, Schroeder JS, Dougall IR (1982) Correlation of an abnormal rest 201-thallium myocardial image: Pathological findings in cardiac transplant recipients. Eur J Nucl Med 7:243–247

    Google Scholar 

  • Mehrotra PP, Weaver YYJ, Higginbotham EA (1983) Myocardial perfusion defect on thallium-201 imaging in patients with chronic obstructive pulmonary disease. J Am Coll Cardiol 2:233–239

    Google Scholar 

  • Meltzer RS (1987) Clinical utility and limitations of contrast echocardiography. In: Pohost GM, Higgins CHB, Morganroth J, Ritchie JL, Schelbert HR (eds) New concepts in cardiac imaging 1987. Year Book Medical Publ, Chicago London, p 35

    Google Scholar 

  • Meyer-Pavel CM, Logic JR (1982) Ischemia-induced transient left bundle branch block during exercise documented by 201-thallium perfusion imaging. Eur J Nucl Med 7:44–46

    Google Scholar 

  • Miller DD, Liu P, Block PC (1986) Prognostic value of exercise thallium imaging early after percutaneous transluminal coronary angioplasty (PTCA): Quantitative and qualitative analysis. J Am Coll Cardiol 5:532

    Google Scholar 

  • Morrow CHE, Schwartz JS, Sutherland DER, Simmons RL (1983) Predictive value of thallium stress testing for coronary and cardiovascular events in uremic diabetic patients before renal transplantation. Am J Surg 146:331–335

    Google Scholar 

  • Müller M, Oberhausen E, Stoll HP, Schmidt EL, Hanser A, Vogel W (1986) 81-Rubidium-81m-Krypton-SPECT-Untersuchungen zur Beurteilung hochgradiger Koronarstenosen. Herz/Kreislauf 3:128–133

    Google Scholar 

  • Müller SP, Creutzig H (1987) SPECT-physikalische und technische Voraussetzungen. Nucl Med 26:58–67

    Google Scholar 

  • Mullani NA (1984) Myocardial perfusion with rubidium-82: Theory relating severity of cornary stenosis to perfusion deficit. J Nucl Med 25:1190–1196

    Google Scholar 

  • Murray DP, Rafiqi E, Murray RG, Littler WA (1986) Prognostic investigations after myocardial infarction: A comparison of radionuclide angiography and 201-Tl-scintigraphy. Eur J Nucl Med 11:381–385

    Google Scholar 

  • Nakajo M, Shapiro B, Glowniak J, Sisson JC, Beierwaltes WH (1983) Inverse relationship between cardiac accumulation of meta-(131I)iodobenzyluanidine and circulating catecholamines in suspected pheochromocytoma. J Nucl Med 24:1127–1134

    Google Scholar 

  • Newth CJL, Corey ML, Fowler RS, Gilday DL (1981) Thallium myocardial perfusion scans for the assessment of right ventricular hypertrophy in patients with cystic fibrosis. Am Rev Respir Dis 124:463–468

    Google Scholar 

  • Nishimura T, Uehara T, Hayashida K, Kozuka T (1987) Clinical significance of 201-Tl-reverse redistribution in patients with aorto-coronary bypass surgery. Eur J Nucl Med 13:139–142

    Google Scholar 

  • Oberhausen E (1981) Strahlenexposition des Patienten und des Personals bei nuklearmedizinischen Untersuchungen des Herzens. In: Hör G, Felix R (eds) Kardiovaskuläre Nuklearmedizin. Schnetztor, Konstanz, p 51

    Google Scholar 

  • O'Connell JB, Robinson JA, Henkin RE, Gunnar RM (1981) Immunosuppressive therapy in patients with congestive cardiomyopathy and myocardial uptake of gallium-67. Circulation 64:780–786

    Google Scholar 

  • O'Hara MJ, Lahiri A, Whittington JR (1985) Detection of high risk coronary artery disease by thallium imaging. Br Heart J 53:616–623

    Google Scholar 

  • Pabst HW, Hör G, Lichte H, Sebening H, Kriegel H (1976) Experience with 201-thallium in detection of myocardial infarction. Eur J Nucl Med 1:19–25

    Google Scholar 

  • Pamelia FX, Gibson RS, Watson DD (1985) Prognosis with chest pain and normal thallium exercise scintigrams. Am J Cardiol 55:920–926

    Google Scholar 

  • Patel J, Henderson J, Park C (1981) Pitfalls in 201-thallium myocardial imaging. J Nucl Med Technol 9:58

    Google Scholar 

  • Patterson RE, Horowitz STF, Eng C, Meller J, Goldsmith STJ (1983) Can noninvasive exercise test criteria identify patients with left main or 3 vessel coronary disease after a first myocardial infarction? Am J Cardiol 51:361–372

    Google Scholar 

  • Patterson RE, Shonkoff D, Churchwell AR, Gober A, Neckman C (1987) How frequent is silent ischemia during exercise SPECT-201-Tl? (abstr no 134). J Nucl Med 28:585

    Google Scholar 

  • Pichard AD, Wiener I, Martinez E, Horowitz S (1981) Septal myocardial perfusion imaging with thallium-201 in the diagnosis of proximal left anterior descending coronary artery disease. Am Heart J 102:30–36

    Google Scholar 

  • Pitt B, Strauss HW (1976) Myocardial perfusion imaging and gated cardiac blood pool scanning: Clinical application. Am J Cardiol 38:739–748

    Google Scholar 

  • Poe ND, Robinson GD, McDonald NS (1973) Myocardial extraction of variously labeled acids and carboxylates. J Nucl Med 14:440

    Google Scholar 

  • Poe ND, Robinson GD, Graham LST, McDonald NS (1976) Experimental basis for myocardial imaging with 123 I-labeled hexadecenoic acid. J Nucl Med 17:1077–1082

    Google Scholar 

  • Poe ND, Robinson GD, Zielinski FW, Cabeen WR (1977) Myocardial imaging with 123I-hexadecenoic acid. Radiology 124:419–424

    Google Scholar 

  • Pohost GM, Fallon JT, Strauss HW (1979) Radionuclide techniques in cardiomyopathy. In: Straus HW, Pitt B (eds) Cardiovascular nuclear medicine, 2nd ed. CV Mosby Company, St Louis Toronto London, p 326

    Google Scholar 

  • Pohost GM, Alpert NM, Ingwall JS, Straus HW (1980) Thallium reditribution: Mechanisms and clinical utility. Semin Nucl Med 10:70

    Google Scholar 

  • Pretschner DP (1981) Planar imaging and picture analysis in nuclear medicine. In: Lindberg DAB, Reichertz PL (eds) Digital image processing in medicine. Springer, Berlin Heidelberg New York, p 1249

    Google Scholar 

  • Pretschner DP (1985) Myokardiale Szintigraphie mit 201-Tl. In: Hundeshagen H (ed) Nuclear medicine, part 3, Diagnostic. II, Encyclopedia of Medical Radiology, vol 15, part 3. Springer, Berlin Heidelberg New York, p 113

    Google Scholar 

  • Pretschner DP, Wolf R, Lichtlen P, Hundeshagen H (1979) Quantitative Auswertung von Myokardszintigrammen. Nuklearmediziner [Suppl] 2:48–58

    Google Scholar 

  • Quyyumi A, Crake T, Wright C, Mockus L, Fox K (1987) The role of ambulatory ST-segment monitoring in the diagnosis of coronary artery disease: Comparison with exercise testing and thallium scintigraphy. Eur Heart J 8:124–129

    Google Scholar 

  • Reifart N, Maul FD, Mützel E, Sarai K (1984) Aortokoronare Bypassoperation bei erheblich reduzierter linksventrikulärer Funktion infolge chronischer Ischämie. Dtsch Med Wochenschr 109:1671–1677

    Google Scholar 

  • Reisman ST, Berman D, Maddahi J, Swan HJC (1985) The severe stress thallium defect: An indicator of critical coronary stenosis. Am Heart J 110:128–134

    Google Scholar 

  • Reske SN, Knapp FF, Nitsch J, Kropp J, Reichmann K, Winkler C (1986) Ergebnisse der Fettsäure-SPECT des Myokard bei der koronaren Herzkrankheit. Nucl Med 25:90–98

    Google Scholar 

  • Rigo P, Bailey IK, Lawrence SC, Griffith MD, Pitt B (1980) Value and limitations of segmental analysis of stress thallium myocardial imaging for localization of coronary artery disease. Circulation 61:973–981

    Google Scholar 

  • Rigo P, Larock MP, Cantineau R (1987) Evaluation of the extent of coronary artery disease with Tc-99m-MIBI, a new myocardial perfusion agent (Abstr No 408). J Nucl Med 28:655

    Google Scholar 

  • Ritchie JL, Williams DL, Harp G (1982) Transaxial tomography with thallium-201 for detecting remote myocardial infarction. Am J Cardiol 50:1236–1241

    Google Scholar 

  • Roesler H, Hess T, Weiss M, Noelpp U (1983) Tomoscintigraphic assessment of myocardial metabolic heterogeneity. J Nucl Med 24:285–296

    Google Scholar 

  • Rothlin ME, Bing RJ (1961) Extraction and release of individual free fatty acids by the heart and fat depots. J Clin Invest 40:1380–1386

    Google Scholar 

  • Rozanski A, Berman DS (1987) The efficacy of cardiovascular nuclear medicine exercise studies. Semin Nucl Med 17:104–120

    Google Scholar 

  • Sauer E, Sebening H, Hör G, Lutilsky L (1977) Myokardszintigraphie mit Thallium-201 bei Patienten mit pulmonaler Hypertonie. In: Daum S (ed) Cor pulmonale chronicum. European Society for Clinical Respiratory Physiology and European Society of Cardiology, München, p 463

    Google Scholar 

  • Schelbert HR (1987) Current status and prospects of new radionuclides and radiopharmaceuticals for cardiovascular nuclear medicine. Semin Nucl Med 17:145–181

    Google Scholar 

  • Schicha H (1986) Nuklearmedizinische Diagnostik in der Kardiologie. Intern Welt 2:31–41

    Google Scholar 

  • Schicha H, Rentrop P, Facorro L, Karsch KR, Blanke H, Kreuzer H, Emrich D (1980) Ergebnisse der quantitativen Myokardszintigraphie mit Thallium 201 in Ruhe und unter maximaler Belastung — Kritische Analyse des prädiktiven Wertes und der klinischen Anwendung. Z Kardiol 69:31–42

    Google Scholar 

  • Schlant RC, Blomquist CG, Brandenburg RO (1986) Guidelines for exercise testing. Circulation 74:653A

  • Schmoliner R, Dudzak R, Kronik G, Hutterer B (1983) Thallium-201 imaging after dipyridamole in patients with coronary multivessel disease. Cardiology 70:145–151

    Google Scholar 

  • Schofer J, Mathey DG, Month R, Bleifeld W (1987) Myokardzintigraphie zur frühzeitigen Erfolgsbeurteilung der Thrombolysetherapie beim akuten Myokardinfarkt. Dtsch Med Wochenschr 112:810–814

    Google Scholar 

  • Sethna DH, Bateman TM, Whiting JS, Forrester JS (1987) comprehensive and quantitative cardiac assessment using CINE-CT: Description of a new clinical diagnostic modality. Am J Card Imag 1:18–28

    Google Scholar 

  • Shah PJ, Shreeve WW (1981) Uptake of Ga-67 in the cardiac region on hypersensitivity angiitis. Clin Nucl Med 6:547–549

    Google Scholar 

  • Shulkin BL, Shapiro B, Tobes MC, Shen SHW, Wieland DM (1986) Iodine 123-4-amino-3-iodobenzylguanidine, a new sympathoadrenal imaging agent: Comparison with iodine 123 metaiodbenzylguanidine. J Nucl Med 27:1138–1142

    Google Scholar 

  • Silber S, Vogler A (1986) Die stumme Myokardischämie: Dimensionierung eines Problems. Intensivmed 23:52–63

    Google Scholar 

  • Silber S, Klein U, Gopple L, Rinke H (1977) Thallium myocardial imaging in patients with hypertrophic cardiomyopathy and with right ventricular overload. Herz 2:176–180

    Google Scholar 

  • Silber S, Vogler YA, Theisen K (1986) Stellenwert von Belastungs-EKG und Herzsintigraphie zur Diagnostik und prognostischen Beurteilung einer koronaren Herzkrankheit. Bayer Intern 4:6–16

    Google Scholar 

  • Singer M, Müller-Brand J, Pfisterer ME, Fridrich R (1987) Thallium-201 myocardial scintigraphy in coronary triple vessel disease: An attempt to increase sensitivity using quantitative methods. Eur J Nucl Med 13:269–273

    Google Scholar 

  • Smeets JP, Nigo P, Legrand V (1981) Prognostic value of thallium-201 stress myocardial scintigraphy with exercise ECG after myocardial infarction. Cardiology [Suppl 2] 68:67–70

    Google Scholar 

  • Sochor H, Ogris E, Huber K, Pachinger O (1987) Infarct imaging with monoclonal antimyosin and Tc-99m-pyrophosphate. In: Schmidt HAE, Emrich D (eds) Nuklearmedizin. FK Schattauer, Stuttgart New York, p 95

    Google Scholar 

  • Spielmann RP, Nienaber CA, Heinemann H, Montz R (1985) Localization of post-infarction myocardial ischemia by 201-thallium emission computed tomography. Nucl Med 24:201–205

    Google Scholar 

  • Spies STA, Meyers SHN, Baresi V (1977) A case of myocardial abscess evaluated by radionuclide techniques: Case report. J Nucl Med 18:1089–1090

    Google Scholar 

  • Spiller P, Schmiel FK, Haude M, Jehle J (1984) Messung der Myokardperfusion mittels digitaler Bildbearbeitung. In: Riemann HE, Kollath J (eds) Digitale Radiographie. Schnetztor, Konstanz, p 176

    Google Scholar 

  • Standke R, Hör G (1980) Sektoranalyse der myokardialen 201-Thallium-Redistributionskinetik. Nuc Comp 11: 249–255

    Google Scholar 

  • Standke R, Hör G (1987) Myocardial scintigraphy with 201 Tl: I. Methodology. Nucl Med 26:149–154

    Google Scholar 

  • Staniloff H, Diamond G, Forrester J (1982) Prediction of death, infarction and worsening chest pain with exercise electrocardiography and thallium scintigraphy. Am J Cardiol 49:967 (abstr)

    Google Scholar 

  • Starling MR, Dehmer GJ, Lancaster JL, Lasher JC (1985) Segmental coronary artery disease: Detection by rotating slant-hole collimator tomography and planar thallium-201-myocardial scintigraphy. Radiology 157:781–787

    Google Scholar 

  • Starling MR, Wals RA, Dehmer GJ, Lasher JC, Blumhardt R (1987) Value of tomographic thallium-201 imaging in patients with chest pain following coronary artery bypass grafting. Clin Nucl Med 12:134–139

    Google Scholar 

  • Stolzenberg J (1980) Dilation of the left ventricular cavity on stress thallium scan as an indicator of ischemic disease. Clin Nucl Med 5:289–291

    Google Scholar 

  • Stolzenberg JR, Pollak H (1979) Absent myocardial uptake of Tl-201 under stress in spite of anatomically normal coronary arteries. J Nucl Med 20:900

    Google Scholar 

  • Stratton JR, Ritchie JL, Hamilton GW, Hammermeister KE, Harker LA (1981) Left ventricular thrombi: In vivo detection by indium-111 platelet imaging and two dimensional echocardiography. Am J Cardiol 47:874–881

    Google Scholar 

  • Taillefer R, Dionne D (1983) Gallium-67 uptake by the heart. Semin Nucl Med 13:176–177

    Google Scholar 

  • Tamaki N, Yonekura Y, Mukai T, Kodama SH (1984a) Stress thallium 201 transaxial emission computed tomography: Quantitative versus qualitative analysis for evaluation of coronary artery disease. J Am Coll Cardiol 4:1213–1221

    Google Scholar 

  • Tamaki N, Kambara H, Kadota K, Suzuki Y (1984b) Improved detection of myocardial infarction by emission computed tomography with thallium-201—Relation to infarct size. Br Heart J 52:621–627

    Google Scholar 

  • Tamaki N, Yonekura Y, Mukai T, Fujita T (1984c) Segmental analysis of stress thallium emission tomography for localization of coronary artery disease. Eur J Nucl Med 9:99–105

    Google Scholar 

  • Tamaki N, Yonekura Y, Kadota K, Kambara H, Torizuka K (1985) Thallium myocardial perfusion imaging in myocarditis. Clin Nucl Med 10:562–566

    Google Scholar 

  • Taylor RR, Mews GC, van der Schaaf A (1980) Exercise and thallium-201 myocardial imaging in relation to coronary artery disease in patients with severe aortic valve disease. Aust N Z J 10/6:636–643

    Google Scholar 

  • Treves ST, Hurwitz R, Strauss HW (1985) Heart. In: Treves ST (ed) Pediatric nuclear medicine. Springer, New York Berlin, p 245

    Google Scholar 

  • Tubau J, Witztum K, Froelicher V, Jensen D (1982) Noninvasive assessment of changes in myocardial perfusion and ventricular performance following exercise training. Am Heart J 104:238–248

    Google Scholar 

  • Tzall WR, Sciacca RR, Blood DK, McCarthy DM (1984) Bayesian analysis using Fourier transforms of thallium-201 scintiscans to predict the presence of coronary artery disease. Am J Cardiol 54:289–293

    Google Scholar 

  • Uhl GS, Kay TN, Hickman R, Montgomery MA, McGranaham GM (1980) Detection of coronary artery disease in asymptomatic aircrew members with thallium-201 scintigraphy. Aviat Space Envir Med 51:1250–1256

    Google Scholar 

  • Uthurralt N, Davies GJ, Parodi O (1981) Comparative study of myocardial ischemia during angina at rest and on exertion using thallium 201 scintigraphy. Am J Cardiol 48:410–417

    Google Scholar 

  • van der Wall EE, den Hollander W, Heidendal GAK, Westera G, Majid PA, Roos JP (1981a) Dynamic myocardial scintigraphy with 123 I-labeled free fatty acid in patients with myocardial infarction. Eur J Nucl Med 6:383–389

    Google Scholar 

  • van der Wall EE, Heidendal GAK, den Hollander W, Westera G, Roos JP (1981b) Metabolic myocardial imaging with 123I-labeled heptadecanoic acid in patients with angina pectoris. Eur J Nucl Med 6:391–396

    Google Scholar 

  • van Train KF, Berman DS, Garcia EV (1986) Quantitative analysis of stress thallium-201 myocardial scintigrams: A multicenter trial. J Nucl Med 27:17–25

    Google Scholar 

  • Verani MS (1983) thallium 201 myocardial scintigraphy — an overview. Clin Nucl Med 8:276–287

    Google Scholar 

  • Voth E, Schicha H, Tebbe U, Neumann P, Emrich D (1987) Fatty acid metabolism in symptomatic patients with mitral valve prolaps but without coronary artery disease — Comparison with Tl-201-myocardial perfusion scintigraphy. Nucl Med 26:172–176

    Google Scholar 

  • Wackers FJTH, Stein R, Pytlik L, Plankey M (1983) Gold-195m for serial first pass radionuclide angiocardiography during upright exercise in patients with coronary artery disease. J Am Coll Cardiol 2:497–505

    Google Scholar 

  • Wackers FJT, Russo DJ, Clements JP (1985) Prognostic significance of normal quantitative planar thallium-201 stress scintigraphy in patients with chest pain. J Am Coll Cardiol 6: 27–30

    Google Scholar 

  • Waschek J, Hinkle G, Basmadjian G, Allen EW, Ice R (1981) Effect of cardiac drugs on imaging studies with thallous chloride Tl-201. Am J Hosp Pharmacol 38:1726–1728

    Google Scholar 

  • Weiss AT, Maddahi J, Lew AS, Shah PK, Ganz W, Swan HJC, Berman DS (1986) Reverse redistribution of thallium 201: A sign of non-transmural myocardial infarction with patency of infarct-related coronary artery. J Am Coll Cardiol 7:61–67

    Google Scholar 

  • Weiss AT, Berman DS, Lew AS, Nielsen J, Potkin B, Swan HJC, Waxman A, Maddahi J (1987) Transient ischemic dilation of the left ventricle on stress thallium-201 scintigraphy: A marker of severe and extensive coronary artery disease. J Am Coll Cardiol 9:752–759

    Google Scholar 

  • Whiting JS, Nivatpumin T, Pfaff M, Vas R (1983) Assessing the coronary circulation by digital angiography: Bypass graft and myocardial perfusion imaging. In: Heintzen PH, Brennecke R (eds) Digital imaging in cardiovascular radiology. Thieme, Stuttgart, p 205

    Google Scholar 

  • Wijns W, Serruys PW, Simoons M (1985) Predictive value of early maximal exercise test and thallium scintigraphy after successful percutaneous transluminal coronary angioplasty. Br Heart J 53:194–200

    Google Scholar 

  • Wiseman J, Rouleau J, Rigo P, Strauss HW, Pitt B (1976) Gallium-67 myocardial imaging for the detection of bacterial endocarditis. Radiology 120:135–138

    Google Scholar 

  • Yates WK (1952) Experimental location of myocardial infarction using radioisotopes. US Armed Forces Med J 3:1597–1602

    Google Scholar 

  • Yeh SDJ, Benua RS (1978) Gallium-67 citrate accumulation in the heart with tumor involvement. Clin Nucl Med 3:103–105

    Google Scholar 

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  1. Division of General Nuclear Medicine, Department of Radiology, University of Frankfurt/Main, Theodor Stern Kai 7, D-6000, Frankfurt, Federal Republic of Germany

    G. Hör

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Dedicated to Prof. Heinz Hundeshagen on the occasion of his 60th birthday

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Hör, G. Myocardial scintigraphy — 25 years after start. Eur J Nucl Med 13, 619–636 (1988). https://doi.org/10.1007/BF00256390

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