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Decreased plasma half-life of cyclophosphamide during repeated high-dose administration

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  • Cyclophosphamide Plasma Half Life
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Summary

Cyclophosphamide was given as IV doses of 50 mg/kg/day on each of four successive days as treatment for ovarian and lung cancer. Blood samples were taken at regular intervals and analysed for cyclophosphamide by gas liquid chromatography.

The plasma half-lives (t1/2) and volumes of distribution (VD) were calculated for each of the treatment days; t1/2 was found to decreased with subsequent doses whereas VD was not significantly changed.

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References

  1. Bagley CM Jr, Bostick FW, DeVita VT Jr (1973) Clinical pharmacology of cyclophosphamide. Cancer Res 33:226

    Google Scholar 

  2. Cohen JL, Jao JY, Jusko WJ (1971) Pharmacokinetics of cyclophosphamide in man. Br J Pharmacol 43:677

    Google Scholar 

  3. D'Incalci M, Bolis G, Facchinetti T, Mangioni C, Morasca L, Morazzoni P, Salmona M (1979) Decreased half-life of cyclophosphamide in patients under continual treatment. Eur J Cancer 15:7

    Google Scholar 

  4. Jardine I, Fenselau C, Appler M, Kan M-N, Brundrett RB, Colvin M (1978) Quantitation by gas chromatography-chemical ionisation mass spectometry of cyclophosphamide, phosphoramide mustard and nornitrogen mustard in the plasma and urine of patients receiving cyclophosphamide therapy. Cancer Res 38:408

    Google Scholar 

  5. Marinello AJ, Gurtoo HL, Struck RF, Paul B (1978) Denaturation of cytochrome P-450 by cyclophosphamide metabolites. Biochem Biophys Res Commun 83:1347

    Google Scholar 

  6. Mullins GM, Colvin M (1975) Intensive cyclophosphamide (NSC-26271) therapy in solid tumours. Cancer Chemother Rep 59:411

    Google Scholar 

  7. Pantarotto C, Bossi A, Belvedere G, Martini A, Donelli MG, Frigerio A (1974) Quantitative GLC determination of cyclophosphamide and isophosphamide in biological specimens. J Pharm Sci 63:1554

    Google Scholar 

  8. Souhami RL, Harper PG, Linch D, Trask C, Goldstone AH, Tobias J, Spiro SG, Geddes DM, Richards JM (1982) High-dose cyclophosphamide with autologous marrow transplantation as initial treatment of small cell carcinoma of the bronchus. Cancer Chemother Pharmacol 8:31

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of Toxicology and Pharmacokinetics, Dept. of Clinical Pharmacology, University College London, 5, University Street, WC1, London

    M. I. Graham, I. C. Shaw, B. Sidau & A. E. M. McLean

  2. Department of Radiotherapy and Oncology, University College Hospital, Gower Street, WC1, London, England

    R. L. Souhami & P. G. Harper

Authors
  1. M. I. Graham
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  2. I. C. Shaw
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  3. R. L. Souhami
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  4. B. Sidau
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  5. P. G. Harper
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  6. A. E. M. McLean
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Graham, M.I., Shaw, I.C., Souhami, R.L. et al. Decreased plasma half-life of cyclophosphamide during repeated high-dose administration. Cancer Chemother. Pharmacol. 10, 192–193 (1983). https://doi.org/10.1007/BF00255760

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  • DOI: https://doi.org/10.1007/BF00255760

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