Skip to main content
SpringerLink
Log in

Mutual inhibition between olivary cell groups projecting to different cerebellar microzones in the cat

  • Published:
Experimental Brain Research Aims and scope Submit manuscript

Summary

This study was carried out predominantly on the b zone in the lateral vermis of the cerebellar anterior lobe. This zone is divided into sagittally oriented microzones which receive a somatotopically organized climbing fibre input.

  1. 1.

    It was shown that the climbing fibre input to one microzone is inhibited by stimulation of a nerve that projects to an adjacent microzone.

  2. 2.

    The degree of inhibition was related to the proximity of the microzones involved.

  3. 3.

    The latency of the inhibition was short and the duration 70–110 ms.

  4. 4.

    The inhibition of climbing fibre responses occurred in the inferior olive and was presumably due to post-synaptic inhibition of the olivo-cerebellar neurones.

  5. 5.

    The mutual inhibition could be produced by antidromic activation of olivo-cerebellar neurones.

  6. 6.

    An inhibition with similar properties as in the b zone, but weaker, was observed between forelimb and hindlimb inputs to the c1 and c3 zones in the pars intermedia. In the c3 zone, an inhibition between adjacent forelimb microzones also occurred.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Andersson G, Eriksson L (1981) Spinal, trigeminal, and cortical climbing fibre paths to the lateral vermis of the cerebellar anterior lobe in the cat. Exp Brain Res 44: 71–81

    Google Scholar 

  • Andersson G, Oscarsson O (1978) Climbing fiber microzones in cerebellar vermis and their projection to different groups of cells in the lateral vestibular nucleus. Exp Brain Res 32: 565–579

    Google Scholar 

  • Armstrong DM, Campbell NC, Edgley SA, Schild RF, Trott JR (1982) Investigations of the olivocerebellar and spinoolivary pathways. In: Chan-Palay V, Palay SL (eds) Cerebellum, New vistas. Exp Brain Res, Suppl 6, pp 195–232

  • Armstrong DM, Eccles JC, Harvey RJ, Matthews PBC (1968) Responses in the dorsal accessory olive of the cat to stimulation of hindlimb afferents. J Physiol (Lond) 194: 125–145

    Google Scholar 

  • Armstrong DM, Harvey RJ (1966) Responses in the inferior olive to stimulation of the cerebellar and cerebral cortices in the cat. J Physiol (Lond) 187: 553–574

    Google Scholar 

  • Armstrong DM, Harvey RJ (1968) Responses of a spino-olivo-cerebellar pathway in the cat. J Physiol (Lond) 194: 147–168

    Google Scholar 

  • Armstrong DM, Harvey RJ, Schild RF (1973a) Cerebello-cerebellar responses mediated via climbing fibres. Exp Brain Res 18: 19–39

    Google Scholar 

  • Armstrong DM, Harvey RJ, Schild RF (1973b) The spatial organisation of climbing fibre branching in the cat cerebellum. Exp Brain Res 18: 40–58

    Google Scholar 

  • Armstrong DM, Harvey RJ, Schild RF (1974) Topographical localization in the olivo-cerebellar projection: An electrophysiological study in the cat. J Comp Neurol 154: 287–302

    Google Scholar 

  • Armstrong DM, Schild RF (1980) Location in the spinal cord of neurons projecting directly to the inferior olive in the cat. In: Courville J, de Montigny C, Lamarre Y (eds) The inferior olivary nucleus, anatomy and physiology. Raven Press, New York, pp 125–143

    Google Scholar 

  • Boesten AJP, Voogd J (1975) Projections of the dorsal column nuclei and the spinal cord on the inferior olive in the cat. J Comp Neurol 161: 215–238

    Google Scholar 

  • Brodal A, Kawamura K (1980) Olivocerebellar projection: a review. Advances in Anatomy, Embryology and Cell Biology 64. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Clendenin M, Ekerot C-F, Oscarsson O, Rosén I (1974) Distribution in cerebellar cortex of mossy fibre afferents from the lateral reticular nucleus in the cat. Brain Res 69: 136–139

    Google Scholar 

  • Crill WE (1970) Unitary multiple-spiked responses in cat inferior olive nucleus. J Neurophysiol 33: 199–209

    Google Scholar 

  • Crill WE, Kennedy TT (1967) Inferior olive of the cat: intracellular recording. Science 157: 716–718

    Google Scholar 

  • Eccles JC, Llinás R, Sasaki K (1966) The excitatory synaptic action of climbing fibres on the Purkinje cells of the cerebellum. J Physiol (Lond) 182: 268–296

    Google Scholar 

  • Ekerot C-F, Larson B (1979) The dorsal spino-olivocerebellar system in the cat. II. Somatotopical organization. Exp Brain Res 36: 219–232

    Google Scholar 

  • Ekerot C-F; Larson B (1982) Branching of olivary axons to innervate pairs of sagittal zones in the cerebellar anterior lobe of the cat. Exp Brain Res 48: 185–198

    Google Scholar 

  • Ekerot C-F, Larson B, Oscarsson O (1979) Information carried by the spinocerebellar paths. In: Granit R, Pompeiano O (eds) Reflex control of posture and movement. Elsevier/North-Holland Biomedical Press, Amsterdam (Prog Brain Res, Vol 50, pp 79–90)

    Google Scholar 

  • Gellman R, Houk JC, Gibson AR (1983) Somatosensory properties of the inferior olive of the cat. J Comp Neurol 215: 228–243

    Google Scholar 

  • Groenewegen HJ, Voogd J (1977) The parasagittal zonation within the olivocerebellar projection. I. Climbing fibre distribution in the vermis of cat cerebellum. J Comp Neurol 174: 417–488

    Google Scholar 

  • Groenewegen HJ, Voogd J, Freedman SL (1979) The parasagittal zonation within the olivocerebellar projection. II. Climbing fibre distribution in the intermediate and hemispheric parts of cat cerebellum. J Comp Neurol 183: 551–602

    Google Scholar 

  • Kawamura K, Hashikawa T (1979) Olivocerebellar projections in the cat studied by means of anterograde axonal transport of labeled amino acids as tracers. Neuroscience 4: 1615–1633

    Google Scholar 

  • Leicht R, Rowe MJ, Schmidt RF (1972) Inhibition of cerebellar climbing fibre activity by stimulation of precruciate cortex. Brain Res 43: 640–644

    Google Scholar 

  • Leicht R, Rowe MJ, Schmidt RF (1973) Cortical and peripheral modification of cerebellar climbing fibre activity arising from cutaneous mechanoreceptors. J Physiol (Lond) 228: 619–635

    Google Scholar 

  • Llinás R, Baker R, Sotelo C (1974) Electrotonic coupling between neurons in cat inferior olive. J Neurophysiol 37: 560–571

    Google Scholar 

  • Llinás R, Yarom Y (1981) Electrophysiology of mammalian inferior olivary neurones in vitro. Different types of voltage-dependent ionic conductances. J Physiol (Lond) 315: 549–567

    Google Scholar 

  • Oscarsson O (1969) Termination and functional organization of the dorsal spino-olivocerebellar path. J Physiol (Lond) 200: 129–149

    Google Scholar 

  • Oscarsson O (1980) Functional organization of olivary projection to the cerebellar anterior lobe. In: Courville J, de Montigny C, Lamarre Y (eds) The inferior olivary nucleus, anatomy and physiology. Raven Press, New York, pp 279–289

    Google Scholar 

  • Oscarsson O, Sjölund B (1977a) The ventral spino-olivocerebellar system in the cat. I. Identification of five paths and their termination in the cerebellar anterior lobe. Exp Brain Res 28: 469–486

    Google Scholar 

  • Oscarsson O, Sjölund B (1977b) The ventral spino-olivocerebellar system in the cat: III. Functional characteristics of the five paths. Exp Brain Res 28: 505–520

    Google Scholar 

  • Rowe MJ (1977) Topography of inhibitory interactions from the cerebral cortex on the climbing fibre input to cerebellar Purkinje cells. Arch Ital Biol 115: 94–107

    Google Scholar 

  • Sotelo C, Llinás R, Baker R (1974) Structural study of inferior olivary nucleus of the cat: Morphological correlates of electrotonic coupling. J Neurophysiol 37: 541–559

    Google Scholar 

  • Takeda T, Maekawa K (1980) Bilateral visual inputs to the dorsal cap of inferior olive: Differential localization and inhibitory interactions. Exp Brain Res 39: 461–471

    Google Scholar 

Download references

Author information

Author notes

  1. G. Andersson

    Present address: Dept. of Physiology, University of Bristol Medical School, University Walk, BS8 1TD, Bristol, England

Authors and Affiliations

  1. Institute of Physiology, University of Lund, Sölvegatan 19, S-223 62, Lund, Sweden

    G. Andersson

Authors
  1. G. Andersson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Andersson, G. Mutual inhibition between olivary cell groups projecting to different cerebellar microzones in the cat. Exp Brain Res 54, 293–303 (1984). https://doi.org/10.1007/BF00236230

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00236230

Key words

Search

Navigation