Summary
Microspectrofluorometry, fluorescence histochemistry and light and electron microscopic autoradiography have established the presence of sub-populations of neurons in the arcuate-periventricular region of the rat hypothalamus that sequester both radiolabeled dopamine and demonstrate formaldehyde-induced fluorescence. These characteristics are consistent with a catecholaminergic function. Selective sequestration of 3H-dopamine at the light and ultrastructural level is discussed in the context of an ultrashort loop autoregulatory mechanism for this neuronal population.
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Supported by USPHS Program Project Grants NS-11642, RR-05403
USPHS Career Development Awardee K04 GM 70001.
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Scott, D.E., Sladek, J.R., Knigge, K.M. et al. Localization of dopamine in the endocrine hypothalamus of the rat. Cell Tissue Res. 166, 461–473 (1976). https://doi.org/10.1007/BF00225911
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DOI: https://doi.org/10.1007/BF00225911