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Morphology of the perivascular regions of the rat neural lobe in relation to hormone release

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Summary

Neural lobes of rats subjected to dehydration by drinking 2% saline for four days were examined electron microscopically and compared to untreated controls. The ultrastructure of the blood vessels and the tissues surrounding them were examined and it was found that, although few exocytotic figures could be seen in either group of animals, a significantly larger (P<0.01) number of small vesicles were found in nerve endings adjacent to the perivascular space in the saline treated group when compared to nerve endings not closely associated with blood vessels. No differences were found in the control group of animals, which supports the suggestion that the vesicles could arise from a membrane recapture process.

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References

  • Barer, R., Lederis, K.: Ultrastructure of the rabbit neurohypophysis with special reference to the release of hormones. Z. Zellforsch. 75, 201–239 (1966)

    Google Scholar 

  • Bargmann, W., Gaudecker, B. von: Über die Ultrastruktur neurosekretorischer Elementar-granula. Z. Zellforsch. 96, 495–504 (1969)

    Google Scholar 

  • Bern, H. A.: The secretory neurone as a doubly specialized cell. In: General physiology of cell specialization, eds. D. Mazia and A. Tyler, New York: McGraw Hill p. 349–366 (1963)

    Google Scholar 

  • Bodian, D.: Cytological aspects of neurosecretion in opossum neurohypophysis. Bull. Johns Hopk. Hosp. 113, 57–93 (1963)

    Google Scholar 

  • Bodian, D.: Herring bodies and neuro-apocrine secretion in the monkey. An electron microscopic study of the fate of the neurosecretory product. Bull. Johns Hopk. Hosp. 118, 282–326 (1966)

    Google Scholar 

  • Boudier, J. A., Detieux, Y.: Effects de la colchicine sur la recharge en neurosécrétat de la neurohypophyse du rat après deplétion par privation d'eau. J. Neurovisc. Rel. 32, 282–297 (1972)

    Google Scholar 

  • Brettschneider, H.: Die Feinstruktur des nervösen Paranchyms von Infundibulum und und Neurohypophyse. Z. mikr.-anat. Forsch. 64, 575–590 (1958)

    Google Scholar 

  • Christ, J. F., Bak, I. J.: Some fine structural observations on the small vesicular components in the posterior pituitary nerve fibers of the rabbit. Z. mikr.-anat. Forsch. 81, 329–344 (1970)

    Google Scholar 

  • Daniel, A. R., Lederis, K.: Effects of ether anaesthetic and haemorrhage on hormone storage and ultrastructure of the rat neurohypophysis. J. Endocr. 34, 91–104 (1966)

    Google Scholar 

  • De Robertis, E.: Ultrastructure and function in some neurosecretory systems. In: Neurosecretion, eds. H. Heller and R.B. Clark, p. 3–20. New York: Academic Press 1962

    Google Scholar 

  • Douglas, W. W., Nagasawa, J.: Membrane vesiculation at sites of exocytosis in the neurohypophysis, adenohypophysis and adrenal medulla: a device for membrane conservation. J. Physiol. (Lond.) 218, 94–95 (1971)

    Google Scholar 

  • Douglas, W. W., Nagasawa, J., Schulz, R.: Coated microvesicles in neurosecretory terminals of posterior pituitary glands shed their coats to become smooth “synaptic vesicles”. Nature (Lond.) 232, 340–341 (1971a)

    Google Scholar 

  • Douglas, W. W., Nagasawa, J., Schulz, R.: Electron microscopic studies on the mechanism of secretion of posterior pituitary hormones and significance of microvesicles (“synaptic vesicles”). In: Subcellular organisation and function of endocrine tissues, eds. H. Heller and K. Lederis, p. 353–378. New York: Cambridge University Press 1971b

    Google Scholar 

  • Duffy, P. E., Menefee, M.: Electron microscopic observations of neuroseeretory granules, nerve and glial fibres and blood vessels in the median eminence of the rabbit. Amer. J. Anat. 117, 251–286 (1965)

    Google Scholar 

  • Duncan, D.: An electron microscopic study of the neurohypophysis of a bird,Gallus Domesticus. Anat. Rec. 125, 457–471 (1956)

    Google Scholar 

  • Dyball, R. E. J., Morris, J. F., Heap, P. F.: The ultrastructure of the hypothalamo-neurohypophysial system of the rat in relation to its secretory and electrical activity. J. Physiol. (Lond.) 222, 22P (1972)

  • Gerschenfeld, H. M., Tramezzani, J. H., De Robertis, E.: Ultrastructure and function of the neurohypophysis of the toad. Endocrinology 66, 741–762 (1960)

    Google Scholar 

  • Hartmann, J. F.: Electron microscopy of the neurohypophysis in normal and histamine treated rats. Z. Zellforsch. 48, 291–308 (1958)

    Google Scholar 

  • Holmes, R. L., Knowles, F. G. W.: “Synaptic” vesicles in the neurohypophysis. Nature (Lond.) 185, 710 (1960)

    Google Scholar 

  • Jones, C. W., Pickering, B. T.: Comparison of the effects of water deprivation and sodium chloride imbibition on the hormone content of the neurohypophysis of the rat. J.Physiol. (Lond.) 203, 449–458 (1969)

    Google Scholar 

  • Knowles, F. G. W.: Evidence for a dual control, by neurosecretion, of hormone synthesis and hormone release in the pituitary of the dogfish Scilliorhinus stellaris. Phil. Trans, roy. Soc. B 249, 435–456 (1965)

    Google Scholar 

  • Koelle, G. B., Geesey, C.: Localisation of acetylcholinesterase in the neurohypophysis and its functional implications. Proc. Soc. exp. Biol. (N.Y.) 106, 625–628 (1961)

    Google Scholar 

  • Lederis, K.: An electron microscopical study of the human neurohypophysis. Z. Zellforsch. 65, 847–868 (1965)

    Google Scholar 

  • Lederis, K.: Phylogenetic aspects of the ultrastructure and function of the vertebrate hypothalamo-neurohypophysial system. J. Endocr. 32, 1 (1966)

    Google Scholar 

  • Lederis, K., Bridges, T. E., Richards, C. R., Santolaya, R. C., Zelnik, P. R.: Ultrastructural and subcellular investigations on exocytosis as a likely mechanism of hormone secretion from the urophysis and neurohypophysis. In: Neurohypophysial hormones, eds. G. E. W. Wolstenholme and J. Birch, p. 45–57. London: Churchill Livingston 1972

    Google Scholar 

  • Lederis, K., Livingston, A.: Subcellular localisation of acetylcholine in the posterior pituitary of the rabbit. J. Physiol. (Lond.) 196, 34–36P (1968)

    Google Scholar 

  • Lederis, K., Livingston, A.: Acetylcholine and related enzymes in the neural lobe and anterior hypothalamus of the rabbit. J. Physiol. (Lond.) 201, 695–709 (1969)

    Google Scholar 

  • Lederis, K., Livingston, A.: Neuronal and subcellular localization of acetylcholine in the posterior pituitary of the rabbit. J. Physiol. (Lond.) 210, 187–204 (1970)

    Google Scholar 

  • Livingston, A.: Ultrastructure of the rat neural lobe during recovery from hypertonic saline treatment. Z. Zellforsch. 137, 361–374 (1973)

    Google Scholar 

  • Livingston, A.: An ultrastructural study of the perivascular regions of the rat neural lobe in relation to hormone release. J. Endocr. 63, 52–53P (1974)

    Google Scholar 

  • Livingston, A., Sooriyamoorthy, T.: Blood flow in the neurohypophysis of the rabbit associated with hormone releasing stimuli. Brit. J. Pharmacol. 45, 142P (1971)

  • Monroe, B. G., Scott, D. E.: Ultrastructural changes in the neural lobe of the hypophysis of the rat during lactation and suckling. J. Ultrastruct. Res. 14, 497–517 (1966)

    Google Scholar 

  • Palay, S. L.: The fine structure of the neurohypophysis. In: Ultrastructure and cellular chemistry of neural tissue, ed. H. Waelsch, p. 31–49. New York: Hoeber, 1957

    Google Scholar 

  • Rodríguez, E. M.: Ultrastructure of the neurohaemal region of the toad median eminence. Z. Zellforsch. 93, 182–212 (1969a)

    Google Scholar 

  • Rodríguez, E. M.: Fixation of the central nervous stem by perfusion of the cerebral ventricles with a threefold aldehyde mixture. Brain Res. 15, 395–412 (1969b)

    Google Scholar 

  • Santolaya, R. C., Bridges, T. E., Lederis, K.: Elementary granules, small vesicles and exocytosis in the rat neurohypophysis after acute haemorrhage. Z. Zellforsch. 125, 277–288 (1972)

    Google Scholar 

  • Sooriyamoorthy, T., Livingston, A.: Vasodilation in the rat neurohypophysis associated with hormone-releasing stimuli. J. Endocr. 51, XI-XII (1971)

    Google Scholar 

  • Sooriyamoorthy, T., Livingston, A.: Variations in the blood volume of the neural and anterior lobes of the pituitary of the rat associated with neurohypophysial hormone-releasing stimuli. J. Endocr. 54, 407–415 (1972)

    Google Scholar 

  • Sooriyamoorthy, T., Livingston, A.: Blood flow studies in the neural lobe of the pituitary of rabbit associated with neurohypophysial hormone releasing stimuli. J. Endocr. 57, 75–85 (1973)

    Google Scholar 

  • Whitaker, S., Labella, F. S.: Ultrastructural localization of acid phosphatase in the posterior pituitary of the dehydrated rat. Z. Zellforsch. 125, 1–15 (1972)

    Google Scholar 

  • Whitaker, S., Labella, F. S., Sanwal, M.: Electron microscopic histochemistry of lysosomes in neurosecretory nerve endings and pituicytes of rat posterior pituitary. Z. Zellforsch. 111, 493–504 (1970)

    Google Scholar 

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  1. Department of Pharmacology, University of Bristol Medical School, Bristol, UK

    A. Livingston

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  1. A. Livingston
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Livingston, A. Morphology of the perivascular regions of the rat neural lobe in relation to hormone release. Cell Tissue Res. 159, 551–561 (1975). https://doi.org/10.1007/BF00221710

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