Abstract
Effects of chronic dietary exposure to low levels of PCBs (polychlorinated biphenyls) on reproduction, growth and whole body burdens were investigated in three generations of Peromyscus polionotus. Mated pairs were maintained on a diet containing 5 mg/kg PCBs (Aroclor 1254®) for 12 months, beginning exposure as young adults; matched controls received a similar diet without PCBs. Offspring were maintained on the parental regime and paired at maturity with non-siblings in the same group. In first and second generation offspring, birth and weaning weights were significantly lower in PCB-exposed animals; in the second generation, there were also significantly fewer mice born/month, longer intervals prior to birth of the first litter, and decreased survival to weaning (25 days) among exposed mice. Whole body residue of PCBs increased significantly with each generation of exposure. This study clearly shows that chronic exposure to PCBs at a dosage of 5 mg/kg depressed fertility, growth and survival in Peromyscus, and that these effects were amplified through multigenerational exposure.
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Batty J, Levitt RA, Biondo N, Polin D (1990) An ecotoxicological study of a population of the white-footed mouse (Peromyscus leucopus) inhabiting a polychlorinated biphenyls-contaminated area. Arch Environ Contam Toxicol 19:282–290
Borlakoglu JT, Clarke S, Huang SW, Dils RR, Haegel KD, Gibson GG (1992) Lactational transfer of 3,3′, 4,4′-tetrachloro-and 2,2′,4,4′,5,5′-hexachlorobiphenyl induces cytochrome P450VA1 in neonates. Biochem Pharmacol 43:153–157
Dawson WD (1965) Fertility and size inheritance in a Peromyscus species cross. Evolution 19:44–55
Dawson WD, Reuning SR, Finlay MF (1982). Immunological factors in Peromyscus speciation. J Exptl Zool 224:1–12
Finlay MF, Philips A, Kennedy N (1979) Effect of cadmium on reproduction and health in Peromyscus (white-footed mice). In: Animals as monitors of environmental pollution. National Academy of Sciences, Washington, DC, p 379
Fuller GB, Hobson WC (1987) Effect of PCBs on reproduction in mammals. In: Ward JS (ed) PCBs in the environment. CRC Press, Ann Arbor, MI, p 101
George CJ, George WJ (1990) Environmental Health. In: Cockerham LG, Shane BS (eds) Basic environmental toxicology. CRC Press, Ann Arbor MI, p 427
Hansen LG (1994) Halogenated aromatic compounds. In: Cockerham LB, Shane BS (eds) Basic environmental toxicology. CRC Press, Ann Arbor MI, p 199
Jensen AA (1983) Chemical contaminants in human milk. Residue Rev 89:1–109
Linzey AV (1987) Effects of polychlorinated biphenyl exposure on reproductive success of white-footed mice (Peromyscus leucopus). Arch Environ Contam Toxicol 16:455–460
— (1988) Effects of chronic polychlorinated biphenyls exposure on growth and reproduction of second generation white-footed mice (Peromyscus leucopus). Arch Environ Contam Toxcol 17:39–45
Litterst CL, Farber TM, Baker AM, VanLoon EJ (1972) Effect of polychlorinated biphenyls on hepatic microsomal enzymes in the rat. Toxicol Appl Pharmacol 23:112–122
McBee K, Bickham JW (1990) Animals as bioindicators of environmental toxicology. In: Genoways HH (ed) Current mammalogy, vol 2. Plenum Press, NY, p 37
Meserve LA, Murray BA, Landis JA (1992) Influence of maternal ingestion of Aroclor 1254® (PCB) or FireMaster BP-6® (PBB) on unstimulated and stimulated corticosterone levels in young rats. Bull Environ Contam Toxicol 48:715–720
Shull LR, Bleavins MR, Olson BA, Aulerich RJ (1982) Polychlorinated biphenyls (Aroclor® 1016 and 1242): Effect on hepatic microsomal mixed function oxidases in mink and ferrets. Arch Environ Contam Toxicol 11:313–321
Silberhorn EM, Glauert HP, Robertson LW (1990) Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs. Crit Rev Toxicol 20:439–496
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McCoy, G., Finlay, M.F., Rhone, A. et al. Chronic polychlorinated biphenyls exposure on three generations of oldfield mice (Peromyscus polionotus): Effects on reproduction, growth, and body residues. Arch. Environ. Contam. Toxicol. 28, 431–435 (1995). https://doi.org/10.1007/BF00211624
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DOI: https://doi.org/10.1007/BF00211624