Abstract
Twelve subjects (3 male) took part in a randomised double-blind four way crossover study designed to examine the cognitive and psychomotor effects of single doses of dextroproxyphene. On four study days one week apart each subject received each study product (i) dextropropoxyphene napsylate 100 mg, (ii) dextropropoxyphene napsylate 200 mg, (iii) lorazepam 2 mg and (iv) placebo. Performance measures were simple reaction time, choice reaction time, number vigilance, memory scanning, word recall (immediate and delayed), word recognition, picture recognition, critical flicker fusion threshold (CFFT) and visual analogue scales of alertness, calmness and contentment. Lorazepam had a marked effect on the range of tests used illustrating the sensitivity of the best battery. This was in contrast to the effects of dextropropoxyphene. A dose related effect in CFFT was detected, the 200 mg dose producing a significant decrease in CFFT throughout the testing period. Dextropropoxyphene also showed a tendency to improve scores on the verbal memory tasks. These data indicate that dextropropoxyphene in the usual doses does not produce significant impairment of cognitive and psychomotor function.
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Bailie R, Christmas L, Price N, Restall J, Simpson P M, Wesnes K (1989) Effects of temazepam premedication on cognitive recovery following alfentanil/propofol anaesthesia. Br J Anaesth 63:68–75
Beaver W T (1984) Analgesic efficacy of dextropropoxyphene and dextropropoxyphene containing combinations: a review. Human Toxicology 3:191S-220S
Birch B, Curran H V (1990) The differential effects of flumazenil on the psychomotor and amnesic actions of midazolam. J Psychopharmacol 4:29–34
Bond A, Lader M (1974) The use of analogue scales in rating subjective feelings. Br J Med Psychol 47:211–218
Curran H V, Allen D, Lader M (1987) The effects of single doses of alpidem and lorazepam on memory and psychomotor performance in normal humans. J Psychopharmacol 2:81–89
Edwards C, Gard P R, Handley S L, Hunter M, Whittington R M (1982) Distalgesic and ethanol-impaired function. Lancet II:384
Girre C, Hirschhorn M, Bertaux L, Palombo S, Dellatolas F, Ngo R, et al (1991) Enhancement of propoxyphene bioavailability by ethanol. Relation to psychomotor and cognitive function in healthy subjects. Eur J Clin Pharmacol 41:147–142
Hanks G W, Hoskin P J (1987) Opioid analgesics in the treatment of pain in patients with cancer. Palliat Med 1:1–25
Jaffe J H, Martin W R (1990) Opioid analgesics and antagonists. In: Goodman Gilman (eds) The Pharmacological Basis of Therapeutics. Pergamon Press, Oxford New York, pp 485–521
Liljequist R (1981) Codeine-induced memory changes: nature and relationship to opiate system. Eur J Clin Pharmacol 20:99–107
Link C G G, Leigh T J, Dennison J K (1993) The effects of BRL 46470A, a novel 5-HT3 receptor antagonist, and lorazepam on psychometric performance and the EEG. Br J Clin Pharmacol 35:395–399
Nickander R C, Emmerson J L, Hynes M D, Steinberg M I, Sullivan H R (1984) Pharmacologic and toxic effects in animals of dextropropoxyphene and its major metabolite norpropoxyphene: a review. Human Toxicology 3:13S-36S
Perrier D, Gibaldi M (1972) Influence of first-pass effect on the systemic availability of propoxyphene. J Clin Pharmacol 12:449–452
Saarialho-Kere U, Julkunen H, Mattila M J, Seppala T (1988) Psychomotor performance of patients with rheumatoid arthritis: cross-over comparison of dextropropoxyphene, dextropropoxyphene plus amitriptyline, indomethacin and placebo. Pharmacol Toxicol 63:286–292
Wesnes K, Simpson P, Kidd A (1988) An investigation of the range of cognitive impairments induced by Scopolamine 0.6 mg sc. Hum Psychopharmacol 3:27–41
Wesnes K A, Simpson P M, Christmas L, McClelland G R, Joiner I M (1989) Acute cognitive effects of moclobemide and trazodone, alone and in combination with alcohol in the elderly. Br J Clin Pharmacol 27:647
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O'Neill, W.M., Hanks, G.W., White, L. et al. The cognitive and psychomotor effects of opioid analgesics. Eur J Clin Pharmacol 48, 447–453 (1995). https://doi.org/10.1007/BF00194333
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DOI: https://doi.org/10.1007/BF00194333