Skip to main content
SpringerLink
Log in

Inflammatorischer pseudotumor der leber —seltene differentialdiagnose einer unklaren hepatischen raumforderung Fallbericht und literaturbersicht

Inflammatory pseudotumor of the liver — rare differential diagnosis of an unknown hepatic mass. Case report and review of the literature

  • Originalarbeit
  • Published:
Langenbecks Archiv für Chirurgie Aims and scope Submit manuscript

Abstract

Hepatic masses are predominantly malignant, and whereas benign tumors are rare. We report the case of a 65-year-old man who presented with an anomalous hepatic mass. Following explorative laparotomy and left lateral segmentectomy (II/III), the patient was diagnosed as having an inflammatory pseudotumor of the liver. So far only 102 cases of “inflammatory pseudotumor of the liver” have been reported in the literature. Asia is a geographical center for this tumor entity, which mostly affects men. The major symptoms are nonspecific: fever, weight loss and general fatigue. The prognosis of “inflammatory pseudotumor of the liver” is very good. In 98% of the cases, a cure has been obtained after surgical therapy, but conservative therapy approaches also yield good results.

Zusammenfassung

Raumforderungen der Leber sind überwiegend maligne, benigne Tumoren der Leber sind selten. Wir berichten über den Fall eines 65 Jahre alten Patienten, dessen unklare Raumforderung der Leber sich erst nach explorativer Laparotomie mit anschließender links-lateraler Segmentresektion (II/III) als inflammatorischer Pseudotumor der Leber herausstellte. In der vorliegenden Literatur sind bis 1996 weltweit lediglich 102 Fälle mit der Diagnose inflammatorischer Pseudotumor der Leber publiziert worden. Ein geographischer Schwerpunkt für diese Tumorentität liegt in Asien, wobei überwiegend Männer betroffen sind. Die Hauptsymptomatik äußert sich unspezifisch in Fieber, Gewichtsverlust und allgemeiner Schwäche. Die Prognose der Erkrankung ist sehr gut. Nach operativer Therapie wird in 98% der Fälle eine Heilung erzielt, aber auch konservative Therapieansätze weisen gute Ergebnisse auf.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Abehsera M, Vilgrain V, Belghiti J, Flejou JF, Nahum H (1995) Inflammatory pseudotumor of the liver: radiologic-pathologic correlation. J Comput Assist Tomogr 19:80–83

    Google Scholar 

  2. Akiyama T, Saito H, Kiriyama M, Tomita F, Kosaka T, Kita I, Takashima S, Matsunou H (1995) A case of gallbladder cancer associated with a common bile duct neuroma, and a cystic lesion of the liver with histological findings similar to those of an inflammatory pseudotumor. J Gastroenterol 30:408–412

    Google Scholar 

  3. Andreola S, Catteoretti G, Laombardi L, Audisio RA (1990) Inflammatory pseudotumor of the liver: report of two cases. Tumori 76:517–523

    Google Scholar 

  4. Anthony PP, Telesinghe P (1986) Inflammatory pseudotumor of the liver. J Clin Pathol 39:761–768

    Google Scholar 

  5. Broughan TA, Fischer WL, Tuthill RJ (1993) Vascular invasion by hepatic inflammatory pseudotumor. A clinicopathololic study. Cancer 71:2934–2940

    Google Scholar 

  6. Brunn WJ, Johnson LC (1939) Two interesting benign lung tumors of contradictory histopathology. Remarks of the necessity for maintaining the chest tumor registry. J Thorac Cardiovasc Surg 9:119–131

    Google Scholar 

  7. Ceppa P, Pastorino A, Colacino R, Baccini P, Badini A, Savarino V (1994) Inflammatory pseudotumor of the liver: report of a case with cytological and histological findings. Pathologica 86:423–426

    Google Scholar 

  8. Chen KTK (1984) Inflammatory pseudotumor of the liver. Hum Pathol 15:694–696

    Google Scholar 

  9. Collina G, Baruzzi G, Eusebi V (1987) Inflammatory pseudotumor of the liver: report of two cases. Tumori 73:407–412

    Google Scholar 

  10. Crawford JM (1994) Liver and biliary tract. In: RS Cotran (ed) Robbins pathologic basis of disease; 5th edn. Saunders, Philadelphia

    Google Scholar 

  11. Feng YQ (1991) Hepatic inflammatory pseudotumor. A report of 5 cases. Chung-Hua Wai Ko Tsa Chih 29:101–103

    Google Scholar 

  12. Flisak ME, Budris DM, Olson MC, Zarling EJ (1994) Inflammatory pseudotumor of the liver: appearance on MRI. Clin Imaging 18:1–3

    Google Scholar 

  13. Fukuya T, Honda H, Matsumata T, Kawanami T, Shimoda Y, Muranaka T, Hayashi T, Maeda T, Sakai H, Masuda K (1994) Diagnosis of inflammatory pseudotumor of the liver: value of CT. Am J Roentgenol 163:1087–1091

    Google Scholar 

  14. Gollapudi P, Chejefee G, Zarling EJ (1992) Spontaneous regression of hepatic pseudotumor. Am J Gastroenterol 87:214–217

    Google Scholar 

  15. Gough J, Chakrabarti S (1993) Inflammatory pseudotumor of the liver in a patient with chronic sclerosing cholangitis. Am J Gastroenterol 88:1452–1453

    Google Scholar 

  16. Grouls V (1987) Pseudolymphoma (inflammatory pseudotumor) of the liver. Zentralbl Pathol 133:565–568

    Google Scholar 

  17. Hakozaki Y, Katou M, Nakagawa K, Shirahama T, Matsomoto T (1993) Improvement of inflammatory pseudotumor of the liver after nonsteroidal anti-inflammatory agent therapy. Am J Gastroenterol 88:1121–1122

    Google Scholar 

  18. Haith EE, Kepes JJ, Holder TM (1964) Inflammatory pseudotumor involving the common bile duct of a six-year-old-boy: successful pancreatico-duodenectomy. Surgery 56:436–441

    Google Scholar 

  19. Hata Y, Sasaki F, Mutuoka S; Hamada H (1992) Inflammatory pseudotumor of the liver in children: report of cases and review of literature. J Pediatr Surg 27:1549–1552

    Google Scholar 

  20. Heneghan MA, Kaplan CG, Priebe CJ, Partin J, Partin JS (1984) Inflammatory pseudotumor of the liver: a rare cause of obstructive jaundice and portal hypertension in a child. Pediatr Radiol 14:433–435

    Google Scholar 

  21. Hertzer NR, Hawk WA, Hermann RE (1971) Inflammatory lesions of the liver which simulate tumor: report of two cases in children. Surgery 69:839–846

    Google Scholar 

  22. Higuchi M, Uchida N, Hattori Y (1982) A case of hepatic xanthogranuloma. Gastroenterol Surg 5:2066–2068

    Google Scholar 

  23. Hirasawa R, Shimohara Y, Yabe H, Tobita A, Kataoka H, Okada K, Ito H, Miyake M (1988) A case of inflammatory pseudotumor of the liver. Nippon Naika Gakkai Zasshi 77:1710–1714

    Google Scholar 

  24. Horiuchi R, Uchida T, Kojima T, Shikata T (1990) Inflammatory pseudotumor of the liver: clinicopathologic study and review of the literature. Cancer 65:1583–1590

    Google Scholar 

  25. Ikeda H, Oka T, Imafuku U (1990) A case of inflammatory pseudotumor of the gallbladder and bile duct. Am J Gastroenterol 85:203–206

    Google Scholar 

  26. Imazato M, Isobe Y, Ueno E (1990) Inflammatory pseudotumor of the liver. Am J Roentgenol 154:201

    Google Scholar 

  27. Isobe H, Nishi Y, Fukotomi T, Iwamoto H, Nakamuta M, Sakai H, Andoh B, Sakamoto S, Nawata H (1991) Inflammatory pseudotumor of the liver associated with acute myelomonocytic leukemia. Am J Gastroenterol 86:238–240

    Google Scholar 

  28. Irie H, Muranka T, Nanjo T, Hamada K, Oshiumi Y (1989) Inflammatory pseudotumor of the liver. Radiation Medicine 7:217–219

    Google Scholar 

  29. Jackson B, Gatling R (1991) Inflammatory pseudotumor of the liver. Surgery 109:329–332

    Google Scholar 

  30. Jais P, Berger JF, Vissuzaine C, Paramelle O, Clays-Schouman E, Potet F, Mignon M (1995) Regression of inflammatory pseudotumor of the liver under conservative therapy. Dig Dis Sci 40:752–756

    Google Scholar 

  31. Jiminez-Mejias ME, Ferrer T, Fernandez-Alomso J, Bernardo A, Leon J, Alarcon A (1989) Inflammatory pseudotumor of the liver. Rev Esp Enferm Dig 76:177–180

    Google Scholar 

  32. Job S, Nishimura H, Matsumoto S, Koganemuru M, Othake H, Kenmochi K, Nakayama K (1988) A case of inflammatory pseudotumor of the liver. Rinsho Hoshasen 33:1039–1042

    Google Scholar 

  33. Kaneko T, Mitarai Y, Watasugi K (1984) A case of inflammatory pseudotumor of the liver. Jpn Soc Pediatr Surg 20:167–171

    Google Scholar 

  34. Kessler E, Turani H, Kayser S, Bar-Ziv J, Chaimoff C (1988) Inflammatory pseudotumor of the liver. Liver 8:17–23

    Google Scholar 

  35. Kuhara N, Yokogawa Y, Dohmen K, Arase K, Nakamura H, Asayama R, Kato M, Nakagaki M, Nojiri I, Takahashi M (1994) Occurence of inflammatory pseudotumor of the liver after the operation for congenital common bile duct dilatation complicated with gallbladder cancer. Nippon Shokakibyo Gakkai Zasshi 91:2009–2015

    Google Scholar 

  36. Le Bail B, Saric J, Balabaud C, Bioulac-Sage P (1992) A desceptive liver tumor: inflammatory pseudotumor. Report of a case. Ann Pathol 12:396

    Google Scholar 

  37. Levitt MD, Rode J, Russell RCG (1988) Inflammatory pseudotumor of the liver. Aust N Z J Surg 58:743–745

    Google Scholar 

  38. Liessi G, Mastapasqua G, Spaliviero B, Butini R, Pavanello M (1995) Pseudotumor of the liver: its imaging with echography, computed tomography and magnetic resonance in a case. Radiol Med 89:545–548

    Google Scholar 

  39. Li GH, Li JQ, Lin YZ (1989) Inflammatory pseudotumor of the liver. J Surg Oncol 42:244–248

    Google Scholar 

  40. Lim JH, Lee JH (1995) Inflammatory pseudotumor of the liver. Ultrasound and CT features. Clin Imag 19:43–46

    Google Scholar 

  41. Lopez JI (1992) Inflammatory pseudotumor of the liver [Letter]. J Clin Gastroenterol 14:274

    Google Scholar 

  42. Lupovitch A, Chen R, Mishra S (1989) Inflammatory pseudotumor of the liver: Report of the fine needle aspiration: cytologic findings in a case initially misdiagnosed as malignant. Acta Cytol 33:259–262

    Google Scholar 

  43. Medline: National library of medicine (Bethesda USA) (1966–1996)

  44. Morita Y, Choji K, Fujita N, Uchino J, Nojima T, Manabe K (1987) A case of inflammatory pseudotumor of the liver. Rinsho Hoshasen 32:537–540

    Google Scholar 

  45. Nakajima T, Sugano I, Matsuzaki O, Nagao K, Kondo Y, Miyazaki M, Konno A, Shimura T (1993) Hepatic inflammatory lesions manifested as a pseudotumor. Report of two cases with different characteristics. Arch Pathol Lab Med 117:157–159

    Google Scholar 

  46. Newbould MJ, Kelsey A, Lendon M, Gururangan S (1992) Inflammatory pseudotumor of the liver masquerading as a metastasis in a child treated for nephroblastoma. Med Pediatr Oncol 20:172–175

    Google Scholar 

  47. Noi I, Loberant N, Cohen I (1994) Inflammatory pseudotumor of the liver. Clin Imag 18:283–285

    Google Scholar 

  48. Pack GT, Baker HW (1953) Total right lobectomy: report of a case. Ann Surg 138:253–258

    Google Scholar 

  49. Paineau J, Gaillard F, Visset J (1983) Inflammatory pseudotumor of the liver: unusual evolution of an unknown abscess? Report of one case. J Chir (Paris) 120:529–533

    Google Scholar 

  50. Pokorny CS, Painter DM, Waugh RC, Mc Caughan GW (1991) Inflammatory pseudotumor of the liver causing biliary obstruction. J Clin Gastroenterol 13:338–341

    Google Scholar 

  51. Sagaswa M, Hukuda K, Tsuchiya Y (1985) A case of hepatic granuloma presenting as a solitary tumor — the problem of differential diagnosis in hepatic tumors. Liver Biliary Syst Pancreas 11:787–791

    Google Scholar 

  52. Schwarz RE, Reynolds JC, Lotze MT (1994) “Pseudo-pseudotumor” of the liver. Adenocarcinoma presenting as an inflammatory pseudotumor. Dig Dis Sci 39:2679–2684

    Google Scholar 

  53. Seco JI, Sanchez Mauel J, Velasco F, Rodrigez Serrano S, Velasco A (1992) Inflammatory pseudotumor of the liver. Rev Esp Enferm Dig 81:138–141

    Google Scholar 

  54. Shek WH, Ng IOL, Chan KW (1993) Inflammatory pseudotumor of the liver, report of four cases and review of the literature. Am J Surg Pathol 17:231–238

    Google Scholar 

  55. Shinada K, Uchino J, Taira T (1980) A case of inflammatory pseudotumor of the liver. Pediatr Oncol 15:26–29

    Google Scholar 

  56. Somoren A (1978) “Inflammatory pseudotumor” of the liver with occlusive phlebitis. Am J Clin Pathol 69:176–181

    Google Scholar 

  57. Sopov GA, Litovka VK, Zhurilo IP (1994) Inflammatory pseudotumor of the liver in a child. Khirurgiia 2:60

    Google Scholar 

  58. Spencer A (1968) Rare pulmonary tumors, Pathology of the lung. Pergamon Press, Oxford New York, p 930

    Google Scholar 

  59. Standiford SB, Sobel H, Dasmahapatra KS (1989) Inflammatory pseudotumor of the liver. J Surg Oncol 40:283–287

    Google Scholar 

  60. Tanino M, Ohta G, Yonashima M (1981) An autopsy case of xanthogranuloma in the liver. Nippon Shokakibyo Gakkai Zasshi 78:1803–1806

    Google Scholar 

  61. Tsao TY, Nieh S, Tseng HH, Tu YC, Liu YC, Chen VT (1990) Inflammatory pseudotumor of the liver with occlusive endophlebitis: report of a case. J Formos Med Assoc 89:818–822

    Google Scholar 

  62. Tsuuchi Y, Kojima K, Seo H, Ohkawa M, Tanabe M, Ikeda K, Satoh A, Hino I (1990) A case of pseudoinfarct of the liver. Rinsho Hoshasen 35:975–978

    Google Scholar 

  63. Uccheddu A, Faa G, Cois A, Ambu R (1995) Inflammatory pseudotumor of the liver. Tumori 81:151–156

    Google Scholar 

  64. Umiker WO, Iverson L (1954) Post-inflammatory “tumors” of the lung: report of four cases simulating xanthoma, fibroma or plasma cell tumor. J Thorac Surg 28:55–63

    Google Scholar 

  65. Ushijima J, Irie K, Nakamura Y, Morimatsu M, Miyaji S (1987) A case of inflammatory pseudotumor in the liver. Pathol Clin Med 5:479–483

    Google Scholar 

  66. Voegt U (1938) Extramedullare plasmocytoma. Virchows Arch 302:497–508

    Google Scholar 

  67. Vujanic GM, Milovanovic D, Aleksandrovic S (1992) Aggressive inflammatory pseudotumor of the abdomen 9 years after therapy for Wilms tumor. A complication, coincidence, or association? Cancer 70:2362–2366

    Google Scholar 

  68. Wee A, Nilsson B, Yap I, Chong SM (1995) Aspiration cytology of liver abscesses. With an emphasis on diagnostic pitfalls. Acta Cytol 39:453–462

    Google Scholar 

  69. Yamauchi T, Furui S, Ohtomo K (1985) A case of inflammatory pseudotumor in the liver. Rinsha Hoshasen 30:1505–1508

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chirurgische Klinik, Universität Hamburg, Hamburg, Germany

    G. Mathiak, U. Meyer-Pannwitt & G. Fröschle

  2. Institut für Pathologie, Universität Hamburg, Hamburg, Germany

    M. Mathiak & S. Schröder

  3. Abteilung für Allgemein- und Thoraxchirurgie, Christian-Albrechts-Universität, Kiel, Germany

    D. Henne-Bruns

  4. Klinikum Köln-Merheim, II. Lehrstuhl für Chirurgie der Universität zu Köln, Ostmerheimer Strasse 200, D-51109, Köln, Germany

    G. Mathiak

Authors
  1. G. Mathiak
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. U. Meyer-Pannwitt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Mathiak
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Schröder
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. Henne-Bruns
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G. Fröschle
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mathiak, G., Meyer-Pannwitt, U., Mathiak, M. et al. Inflammatorischer pseudotumor der leber —seltene differentialdiagnose einer unklaren hepatischen raumforderung Fallbericht und literaturbersicht. Langenbecks Arch Chir 381, 309–317 (1996). https://doi.org/10.1007/BF00191310

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00191310

Key words

Search

Navigation