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Organization of the serotoninergic system in the brain of two amphibian species, Ambystoma mexicanum (Urodela) and Typhlonectes compressicauda (Gymnophiona)

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Abstract

An immunocytochemical investigation was made of the distribution of serotonin (5-HT) in the brain of larval and adult Ambystoma mexicanum and adult Typhlonectes compressicauda. Immunoreactive perikarya can be identified in the caudal diencephalon (paraventricular organ and infundibular nucleus), in the ventral mesencephalon (interpeduncular nucleus) and in the raphe of the rhombencephalon. Immunopositive fibers and terminal arborizations are widely distributed, extending from the whole telencephalon to the spinal lemniscus area. However, the retinorecipient structures of the thalamus and mesencephalon are either very weakly innervated (Ambystoma) or completely immunonegative (Typhlonectes). The habenular system also exhibits very few 5-HT-positive structures. The major serotoninergic neuron clusters, in both Urodela and Gymnophiona, tend to gather, from the paraventricular organ to the raphe, on both sides of the sagittal plane, showing no tendency to “lateralization”. A new interpretation of the limited development of the serotoninergic system in amphibians is given.

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Authors and Affiliations

  1. Neuroembryologie, Université Paris 7, F-75005, Paris, France

    P. Clairambault, N. Christophe & C. Pairault

  2. Laboratoire d'Anatomie Comparée, Muséum d'Histoire Naturelle, F-75005, Paris, France

    M. Herbin, R. Ward & J. Reperant

  3. INSERM U-106, Hôpital de la Salpêtrière, F-75013, Paris, France

    M. Herbin & J. Reperant

  4. Laboratoire de Neuropsychologie, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada

    R. Ward

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  1. P. Clairambault
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  2. N. Christophe
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  4. M. Herbin
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  6. J. Reperant
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Clairambault, P., Christophe, N., Pairault, C. et al. Organization of the serotoninergic system in the brain of two amphibian species, Ambystoma mexicanum (Urodela) and Typhlonectes compressicauda (Gymnophiona). Anat Embryol 190, 87–99 (1994). https://doi.org/10.1007/BF00185849

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