Summary
Some controversy has existed regarding the nosology of meningeal hemangiopericytoma. In the WHO's classification of 1979 these tumours were included as a subgroup of meningiomas, but for some authors, they should not be classified as meningiomas. Cytogenetic studies on meningioma demonstrate monosomy or partial deletion of chromosome 22 in 60% of these tumors. There have been few cytogenetic studies about meningeal hemangiopericytoma. We present here the results of cytogenetic studies and fluorescence in situ hybridization in six cases of meningeal hemangiopericytoma. In these tumours we have never found monosomy 22, but all six cases were hyperdiploid. These cytogenetic data might provide additional evidence to differenciate the meningeal hemangiopericytoma from the meningioma.
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References
Zülch KJ: International histological classification of tumors. In: Histological types of tumors of the central nervous system. World Health Organization (ed), Genova 1979, pp 40–52
Jellinger K, Paulus W Slowik F: The enigma of meningeal hemangiopericytoma. Brain Tumor Pathol 8:33–43,1991
Kleihues P, Burger PC, Scheithauer BW: Histological typing of the tumours of the central nervous system. 2ndEd Springer-Verlag (ed), Berlin 1993, pp 7–8
Lopez-Gines C, Piquer J, Cedra Nicolas M, Barcia Salorio J, Barcia Marino C: Meningiomas: Karyotypes and histological patterns. Clin Neuropathol 8:130–133,1989
Mark J: Chromosomal patterns in human meningiomas. Eur J Cancer 6:489–498,1970
Poulsgård L, Schøder HD, Rønne M:Cytogenetic studies of 11 meningiomas and their clinical significance. II. Anticancer Res 10:535–538, 1990
Yamada K, Kondo T, Yoshioka M, Oami H: Cytogenetic studies in 20 human brain tumors: association of n° 22 chromosome abnormalities with tumors of the brain. Cancer Genet Cytogenet 2:293–307,1980
Zankl H, Zang KD: Correlation between clinical and cytogenetic data in 180 meningiomas. Cancer Genet Cytogenet 1:351–356,1980
Becher R, Wake N, Gibas Z, Ochi H, Sandberg AA: Chromosome changes in soft tissue sarcomas. J Nat Cancer Inst 72:823–831,1984
Bello MJ, Rey JA, Pestana A, De Campos JM, Sarasa JL, Kusak ME, Vaquero J: Meningeal hemangiopericytoma or hemangiopericytic meningioma? A cytogenetic and molecular analysis. Cancer Genet Cytogenet 63:78–80,1992
Limon J, Rao U, Dal Cin P, Gibas Z, Sandberg AA: Translocation (13; 22) in a hemangiopericytoma. Cancer Genet Cytogenet 21:309–318,1986
Mandahl N, Orndal C, Heim S, Witten H, Rydholm A, Bauer HCF, Mitelman F: Aberrations of chromosome segment 12q13–15 characterize a subgroup of hemangiopericytomas. Cancer 71:3009–3013,1993
Sreekantaiah C, Bridge JA, Rao UNM, Neff JR, Sandberg AA: Clonal chromosomal abnormalities in hemangiopericytoma. Cancer Genet Cytogenet 54:173–181,1991
Dutrillaux B, LeJeune J: Sur une nouvelle technque d'analyse du caryotype humain. (A new technique for human karyotype analysis) C R Acad Sci (Paris) 272:2638–2640,1971
ISCN: An international system for human cytogenetic nomenclature. High resolution banding. Cytogenet Cell Genet 31:1–23,1981
Arnoldus PJ, Noordermeer IA, Boudewijn Peters AC, Voormolen JH, Bots GT, Raap AK, Van der Ploeg M: Interphase cytogenetics of brain tumors. Genes Chrom Cancer 3:101–107,1991
DeLattre O, Azambuja CJ, Aurias A, Zucman J, Peter M, Zhang F, Hors-Cayla MC, Rouleau G, Thomas G: Mapping of human chromosome 22 with a panel of somatic cell hybrids. Genomics 9:721–727 1991
Benkhalifa M, Arnold N, Le Corvaisier B, Geinex A, Malet P: Human sex determination by in situ hybridization using non radioactive probes. Genet Set Evol 23:70s–72s,1991
Al Saadi A, Latimer F, Madercic M, Robbins T: Cytogenetic studies of human brain tumors and their clinical significance: II meningioma. Cancer Genet Cytogenet 26:127–141, 1991
Katsuyama J, Papenhausen RR, Hertz F, Gazivoda P, Hirano A, Koss LG: Chromosome abnormalities in meningiomas. Cancer Genet Cytogenet 22:63–68,1986
Mitelman F: Chromosome 22. In: Catalog of chromosome aberrations in cancer. Wiley-Liss Inc (ed) 4th edition New-York 1991 pp 1636–1639
Rey JA, Bello MJ, De Campos JM, Kusak E, Moreno S: Chromosomal involvement secondary to −22 in human meningiomas. Cancer Genet Cytogenet 33:275–290,1988
Vagner-Capodano AM, Grisoli F, Gambarelli D, Sedan R, Pellet W, DeVictor B: Correlation between cytogenetic and histopathological findings in 75 human meningiomas. Neurosurgery 32:892–900,1993
Henn W, Wullich B, Thönnes M, Steudel WI, Feiden W, Zang KD: Recurrent t(12;19) (q13; q13–3) in intracranial and extracranial hemangiopericytoma. Cancer Genet Cytogenet 71:151–154,1993
Sandberg AA: Historical background. In: The chromosomes in human cancer and leukemia: Elsevier Science Publishing Co, Inc (ed) New-York 1990, pp 1–10
Dumanski JP, Rouleau GA, Nordenskjöld M, Collins VP: Molecular genetic analysis of chromosome 22 in 81 cases of meningiomas. Cancer Res 50:5863–5867,1990
Sanson M, Richard S, DeLattre O, Foncin JF, Cornu P, Thomas G: Genotypic differences in hemangiopericytic meningioma. Human Pathol 22:402,1991
Bouillot P, Figarella-Branger D, De Victor B: Quantitative analysis imaging of estrogen and progesteron receptors, p52, growth factors (Ki 67) immunocytochemical assays in 52 meningiomas: correlations with clinical and morphological data. J Neurosurg 81, 765–773,1994
Figarella-Branger D, Pellissier JF, Bouillot P, Bianco N, Mayan M, Grisoli F, Rougon G: Expression of N-CAM isoforms and epithelial cadherin adhesion molecules in 47 human meningiomas. Correlation with clinical and morphological data. Modern Pathol 7, 752–761,1994
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Zattara-Cannoni, H., North, M.O., Gambarelli, D. et al. The contribution of cytogenetics to the histogenesis of meningeal hemangiopericytoma. J Neuro-Oncol 29, 137–142 (1996). https://doi.org/10.1007/BF00182136
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DOI: https://doi.org/10.1007/BF00182136