Summary
The release of adrenal catecholamines into the adrenal vein elicited by splanchnic nerve stimulation, was evaluated in the presence of a β-adrenoceptor agonist and both β-1 and β-2 adrenoceptor antagonists in anaesthetized and vagotomized dogs. Stimulations (0.5 V pulses of 2 ms duration for 3 min at 1 Hz) were applied before and after the i.v. infusion of the β-adrenoceptor agonist, isoproterenol (0.1 μ/kg/min). While maintaining the infusion of isoproterenol, either ICI 118551 (0.3 mg/kg), a selective β-2 adrenoceptor antagonist, or 204-155 (0.2 mg/kg), a selective β-1 adrenoceptor antagonist (Sandoz Co., Dorval, PQ, Canada), were injected intravenously and the stimulation was repeated. The results show that isoproterenol increased significantly both pre-stimulation basal levels and the stimulated release of catecholamines. These potentiated responses were significantly reversed by ICI 118551, but not by 204155. These results suggest that the release of adrenal catecholamines is locally modulated by a positive feedback mechanism through activation of β-2 adrenoceptors.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Boonyaviroj P, Gutman Y (1977) Acetylcholine and CAMP in adrenal medulla: Indirect effect. Naunyn-Schmiedeberg's Arch Pharmacol 297:241–243
Boonyaviroj P, Gutman Y (1979) Alpa- and beta-adrenoceptors and PGE2 in the modulation of catecholamine secretion from bovine adrenal medulla in vitro. J Pharm Pharmacol 31:716–717
Boudreau G, Péronnet F, Yamaguchi N, de Champlain J, Nadeau R (1987) Epinephrine modulation of norepinephrine release of the cardiac sympathetic nerves in the dog: sympathetic nerves in the dog: effect of acute prolonged exercise. Can J Sport Sci 12:4P
Bülbring E, Burn JH, de Elio FJ (1948) The secretion of adrenaline from the perfused suprarenal gland. J Physiol (Lond) 107:222–232
Collett AR, Rand MJ, Story DF (1984) Catecholamines secretion from the rabbit adrenal gland is not modulated by a mechanism involving beta-adrenoceptors. Arch Int Pharmacodyn Ther 269:63–69
Dahlof C, Hedberg A, Nerme V (1986) Evidence for prejunctionaly located beta-2 adrenoceptors in the cat spleen. Naunyn-Schmiedeberg's Arch Pharmacol 333:362–367
Foucart S, Nadeau R, de Champlain J (1987) The release of catecholamines from the adrenal medulla and its modulation by alpha-2 adrenoceptors in the anaesthetized dog. Can J Physiol Pharmacol 65:550–557
Foucart S, de Champlain J, Nadeau R (1988) In vivo modulation by α-2 adrenoceptors of adrenal catecholamines release in the anaesthetized dog. Can J Physiol Pharmacol (in press)
Hjemdhal P, Daleskog M, Kahan T (1979) Determination of plasma catecholamines by high performance liquid chromatography with electrochemical detection: comparison with a radioenzymatic method. Life Sci 25:131–138
Johnston H, Majewski H (1986) Prejunctional beta-adrenoceptors in rabbit pulmonary artery and mouse atria: effect of alphaadrenoceptor blockade and phosphodiesterase inhibition. Br J Pharmacol 87:553–562
Langer SZ (1981) Presynaptic regulation of the release of catecholamines. Pharmacol Rev 32:337–362
Majewski H (1983) Modulation of noradrenaline release through activation of presynaptic beta-adrenoceptors. J Auton Pharmacol 3:47–60
Majewski H, Rand MJ (1981) An interaction between prejunctional alpha-adrenoceptors and prejunctional beta-adrenoceptors. Eur J Pharmacol 69:493–498
Majewski H, Rand MJ (1986) A possible role of epinephrine in the development of hypertension. Med Res Rev 6:467–486
Malhotra RK, Wakade AR (1987) Vasoactive intestinal polypeptide stimulates the secretion of catecholamines from the rat adrenal gland. J Physiol (Lond) 388:285–294
Michener ML, Peach MJ (1984) Failure of beta-adrenergic receptors to modulate adrenal medullary secretion. Biochem Pharmacol 33:1819–1823
Milavec-Krizman M, Evenou J-P, Wagner H, Berthold R, Stoll AP (1985) Characterization of beta-adrenoceptor subtypes in rat kidney with new highly selective beta-1 blockers and their role in renin release. Biochem Pharmacol 34:3951–3957
Misu Y, Kubo T (1986) Presynaptic beta-adrenoceptors. Med Res Rev 6:197–225
Misu Y, Kaiho M, Ogawa K, Kubo T (1981) Adrenergic transmission failure via the blockade of presynaptic beta receptors in guinea-pig pulmonary artery. J Pharmacol Exp Ther 218:242–247
Nathanson JA (1984) ICI 118,551: an effective ocular hypotensive agent with selectivity for ciliary process beta-2 adrenoceptors and with minimal cardiac side effects. Br J Pharmacol 83:821–829
O'Donnell SR, Wanstall JC (1980) Evidence that ICI 118,551 is a potent, highly beta-2-selective adrenoceptor antagonist and can be used to characterize beta-adrenoceptor populations in tissues. Life Sci 27:671–677
Schmidt HHHW, Schurr C, Hedler L, Majewski H (1984) Local modulation of noradrenaline release in vivo: presynaptic beta-2 adrenoceptors and endogenous adrenaline. J Cardiovasc Pharmacol 6:641–649
Serck-Hansen G (1974) Effects of theophylline and propanolol on acetylcholine induced release of adrenal medullary catecholamines. Biochem Pharmacol 23:2225–2234
Starke K (1981) Presynaptic receptors. Annual Rev Pharmacol Toxicol 21:7–30
Wakade AR (1981) Studies on secretion of catecholamines evoked by acetylcholine and transmural stimulation of rat adrenal gland. J Physiol (Lond) 313:481–498
Winer BJ (1971) Single factor experiments having repeated measures on the same elements. In: Statistical principles in experimental design. McGraw-Hill, New York, pp 261–308
Yamaguchi N, de Champlain J, Nadeau RA (1977) Regulation of norepinephrine release from cardiac sympathetic fibers in the dog by presynaptic alpha- and beta-receptors. Circ Res 41:108–117
Author information
Authors and Affiliations
Additional information
Send offprint requests to S. Foucart
Rights and permissions
About this article
Cite this article
Foucart, S., Nadeau, R. & de Champlain, J. Local modulation of adrenal catecholamines release by beta-2 adrenoceptors in the anaesthetized dog. Naunyn-Schmiedeberg's Arch Pharmacol 337, 29–34 (1988). https://doi.org/10.1007/BF00169473
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00169473