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Inhibitory effects of propiverine on rat and guinea-pig urinary bladder muscle

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Summary

In muscle strips isolated from guinea-pig and rat urinary bladder, propiverine (3–10 μM) inhibited carbachol-induced contractions in the presence of verapamil and Ca2+-induced contractions in excess K+ medium containing atropine, suggesting it has both anticholinergic and Ca2+ channel blocking actions.

The Ca2+ channel blocking action was also demonstrated by recording inward Ca 2+ currents in single cells dispersed from both species. The inhibition of inward currents by propiverine was three times stronger in the rat than the guinea-pig, ID50 being 7 μM for rat and 21 μM for guinea-pig. The recovery of the current after washout was faster than that of mechanical inhibition. It is concluded that propiverine blocks not only muscarinic receptors, but also Ca2+ channels at similar concentrations.

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References

  • Bolton TB (1979) Mechanisms of action of transmitters and other substances on smooth muscle. Physiol Rev 59:606–718

    Google Scholar 

  • Dorschner W, Jacob J, Höfner K, Dieterich F (1982) Die Wirkung des Anticholinergikums Mictonorm auf den unteren Harntrakt. Dt Gesundh Wesen 37:950–952

    Google Scholar 

  • Haruno A, Yamasaki Y, Miyoshi K, Miyake H, Tsuchiya K, Kosaka M, Nagai M, Iriki M (1989) Effects of propiverine hydrochloride and its metabolites on isolated guinea pig urinary bladder. Folia pharmacol japon 94:145–150

    Google Scholar 

  • Inoue R, Brading AF (1990) The properties of the ATP-induced depolarization and current in single cells isolated from the guinea-pig urinary bladder. Br J Pharmacol 100:619–625

    Google Scholar 

  • Klöckner U, Isenberg G (1985) Calcium currents of cesium loaded isolated smooth muscle cells (urinary bladder of the guinea-pig). Pflügers Arch 405:340–348

    Google Scholar 

  • Vietinghoff G, Hammer S (1981) Untersuchung der antispasmodischen Wirkung von α,α-Diphenyl-α,n-propoxy-essigsäure-4-(1-methyl-piperidyl)-ester (Mictonorm) an der isolierten Meerschweinchenharnblase. Zbl Pharm 120:1219–1224

    Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, School of Medicine, Nagoya University, 466, Nagoya, Japan

    H. Tokuno, J. U. Chowdhury & T. Tomita

Authors
  1. H. Tokuno
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  2. J. U. Chowdhury
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  3. T. Tomita
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Correspondence to: T. Tomita at the above address

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Tokuno, H., Chowdhury, J.U. & Tomita, T. Inhibitory effects of propiverine on rat and guinea-pig urinary bladder muscle. Naunyn-Schmiedeberg's Arch Pharmacol 348, 659–662 (1993). https://doi.org/10.1007/BF00167244

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  • DOI: https://doi.org/10.1007/BF00167244

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