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Open-loop control of specific growth rate in fed-batch cultures of recombinant E.coli

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Biotechnology Techniques

Summary

A computer-based algorithm was used for the open-loop control of specific growth rate in fed-batch cultures of recombinant E.coli.. The control of nutrient feed rate to an exponential trajectory resulted in growth of the culture at a constant specific growth rate. Stable specific growth rates between 0.08 and 0.4 h−1 were achieved.

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References

  • Gregory, M.E., Dean, P, Keay, P.J. and Thornhill, N.F. (1993) Journal of Biotechnology, in press.

  • Pirt, S.J. (1975) Principles of microbe and cell cultivation. Blackwell Press. Oxford, U.K.

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Authors and Affiliations

  1. Centre for Process Systems Engineering, Imperial College of Science Technology and Medicine, SW7, London, UK

    M. E. Gregory

  2. Advanced Centre for Biochemical Engineering, University College London, WC1E 7JE, Torrington Place, London, UK

    C. Turner

Authors
  1. M. E. Gregory
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  2. C. Turner
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Gregory, M.E., Turner, C. Open-loop control of specific growth rate in fed-batch cultures of recombinant E.coli . Biotechnol Tech 7, 889–894 (1993). https://doi.org/10.1007/BF00156368

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  • DOI: https://doi.org/10.1007/BF00156368

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