Abstract
Epidemiological observations indicate that high plasma fibrinogen levels are strongly correlated to the frequency of two major thrombotic complications of atherosclerosis: stroke and myocardial infarction. Thrombosis is increasingly recognized as a central mechanism in stroke and myocardial infartion, and fibrinogen is involved in events thought to play a major role in thrombosis. Therefore, elucidation of the relationship between fibrinogen and thrombosis may strengthen the predictive value of this protein and define new interventions against stroke and myocardial infarction. In addition, advances in the understanding of the atherogenic potential of several risk factors of coronary heart disease took advantage of information emerging from the measurement of the factor in population-based studies. Thus, it is conceivable that measuring plasma fibrinogen to predict stroke and myocardial infarction is a major direction to be followed to gain insight into the thrombogenic potential on this protein and inspire new strategies against thrombotic complications of atherosclerosis.
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AltieriD.C.,MannucciP.M., andCapitanioA.M. (1986): Binding of Fibrinogen to Human Monocytes -J. Clin. Invest78: 968–976.
BalleisenL.,BaileyJ.,EppingP.H.,ShulteH. andVan deLooJ. (1985): Epidemiological Study on Factor VII — Factor VIII and Fibrinogen in an Industrial Population I — Baseline Data on the Relation to the Age, Gender, Body Weight, Smoking, Alcohol, Pill Using and Menopause - Thrombos. Haemostas.54: 475–479.
BarbieriC.,BalconiG.,DejanaE. andDonatiM.B. (1981): Evidence that Vascular Endothelial Cells can Induce the Retraction of Fibrin clots - Proc. Soc. Exp. Biol. Med.168: 204–7.
ChapmanJr.H.A.,VavrinZ. andHibbaJ.B. (1983): Coordinate Expression of Macrophage Procoagulant and Fibrinolytic Activityin vitro andin vivo - J. Immunol130: 261–6.
ColvinR.B. andDvorackH.F. (1981): Fibrinogen/ Fibrin on the Surface of Macrophages, Detection, Distribution, Binding Requirements and Possible Role in Macrophage Adherence Phenomena - J. Exp. Med.142: 1377–90.
DaviesM.J.,WoolfN. andRobertsonW.B. (1976): Pathology of Acute Myocardial Infarction with Particular Reference to Occlusive Coronary Thrombi- Br. Heart J.38: 659–64.
DejanaE.,LanguinoL.R.,PolentaruttiN.,BalconiG.,RyckewaertJ.J.,LarrieuM.J.,DonatiM.B.,MantovaniA. andMarguerieG. (1985): Interaction between Fibrinogen and Cultured Endothelial Cells. —Induction of Migration and Specific Binding - J. Clin. Invest75: 11–8.
DiMinnoG. andManciniM. (1990): Measuring plasma fibrinogen to predict stroke and myocardial infarction - Arteriosclerosis10: 1–7.
FitzgeraldD.J.,RoyL.,CatellaF. andFitzgeraldG.A. (1986): Platelet Activation in Unstable Angina - N. Engl. J. Med.315: 983–9.
ForresterJ.S.,LitvackF.,GrundfestW. andHickeyA. (1987): A Perspective of Coronary Disease Seen Through the Arteries of Living Man - Circulation75: 505–13.
FusterV. andCheseboroJ.H. (1986): Mechanisms of Unstable Angina - New Engl. Med.315: 1023–5.
GallusA.S. (1986): The Use of Antithrombotic Drugs in Artery Disease - Clin. Haematol.15: 509–60.
GrundyS.M. (1986): State of the Art: Cholesterol and Coronary Heart Disease. A New Era - JAMA256: 2849–58.
HamstenA.,IseliusL.,DeFaireU. andBlombackM. (1987): Genetic and Cultural Inheritance of Plasma Fibrinogen Concentration - Lancetii: 988–91.
HantganR.R.,FrancisC.W.,ScheragaH.A. andMarderV.J. (1987): Fibrinogen Structure and Physiology - In: Hemostasis and Thrombosis Basic Principles and Clinical Practice - Colman R.W., Hirsh J., Marder V.J., Salzman E.W. - Eds. Second Edition - Philadelphia, J.B. Lippincott Co. 269–88.
HirshJ. (1987): Hyperreactive Platelets and Complications of Coronary Artery Disease - N. Engl. J. Med.316: 1543–4.
HoggN. (1983): Human Monocytes are Associated with the Formation of Fibrin - J. Exp. Med.157: 473–85.
HumphriesS.E.,CookM.,DubowitzM.,StirlingY. andMeadeT.W. (1987): Role of Genetic Variations at the Fibrinogen Locus in Determination of Plasma Fibrinogen Concentrations - Lanceti: 1452–5.
KannelW.B.,WolfP.A.,CastelliW.P. andD'AgostinoR.B. (1987): Fibrinogen and Risk of Cardiovascular Disease. The Framingham Study - JAMA258: 118–36.
LeonardE.F. (1987): Rheology in Thrombosis - In: Hemostasis and Thrombosis Basic Principles and Clinical Practice - Colman R.W. - Hirsh J., Marder V.J. and Salzman E.W. - Eds. Second Edition -Philadelphia - J.B. Lippincott Co. 1111–22.
LoweG.D.O. (1986): Blood Rheology in Arterial Disease - Clin. Sci.71: 137–46.
McDonaghJ. andCarrellN. (1987): Disorders of Fibrinogen Structure and Function - In: Hemostasis and Thrombosis Basic Principles and Clinical Practice - Colman R.W., Hirsh J., Marder V.J. and Salzman E.W. - Eds. Second Edition - Philadelphia -J.B. Lippincott Co. 289–300.
MeadeT.W.,BrozovicM.,ChakrabartiR.R.,HainesA.P.,ImesonI.D.,MellowsS.,MillerG.I.,NorthWRSStirlingY. andTompsonS.G. (1986): Haemostatic Function and Ischemic Heart Disease: Principal Results of the Northwick Park Heart Study - Lancetii: 533–7.
MeadeT.W.,ChakrabartiR.,HainesA.P.,NorthWRSStirlingY.,ThompsonS.G. andBrozovicM. (1980): Haemostatic Function and Cardiovascular Death: Early Results of a Prospective Study - Lanceti: 1050–4.
MeadeT.W.,ImesonJ. andStirlingY. (1987): Effects of Changes in Smoking and Other Characteristics on Clotting Factors and the Risk of Ischaemic Heart Disease - Lancetii: 986–9.
Nurden A.T. (1987): Platelet-Membrane Glycoproteins and Their Clinical Aspects - In: Thrombosis and Haemostasis - Vestraete M., Vermylen J., Lijnen R. and Arnout J. - Eds. Leuven Univ. Press. 93–125.
PackhamM.A. andMustardJ.F. (1986): The role of Platelets in the Development and Complications of Atherosclerosis - Semin. Haematol.23: 8–26.
PrestonE.E. (1983): Aspirin — Prostaglandins and Peripheral Gangrene - Am. J. Med.74 (suppl.): 55–60.
SchaferA.I. (1984): Bleeding and Thrombosis in the Myeloproliferative Disorders - Blood64: 1–12.
ShelleyW.B. andJuhlinL. (1977): Induction of Fibrin Thrombi by Monocytes - Nature270: 343–344.
ShermanL.A. andLeeJ. (1987): Specific Binding of Soluble Fibrin to Macrophages - J. Exp. Med.145: 76–85.
SmithE.B. (1986): Fibrinogen, Fibrin and Fibrin Degradation Products in Relation to Atherosclerosis -Clin. Haematol.15: 355–70.
StoneM.C. andThorpeJ.M. (1985): Plasma Fibrinogen a Major Coronary Risk Factor - J. Royal Coll. Gen. Pract.35: 565–9.
ToflerG.H.,BrezinskyD.,SchaferA.I.,CzeislerC.A.,RutherfordJ.D.,WillichS.N.,GleasonR.E.,WilliamsG.H. andMullerJ.E. (1987): Concurrent Morning Increase in Platelet-Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death -N. Engl. J. Med.316: 1514–8.
WanghL.J.,HollandL.J.,SpolskiR.J.,AprisonB.S. andWeiselJ.W. (1983): Xenopus Fibrinogen: Characterization of Subunit and Hormonal Regulation of Biosynthesis - J. Biol. Chem.258: 4599–605.
WautierJ.L.,PintignyD.,WautierM.P.,PatonR.C.,GalacterosF.,PassaP. andCaenJ.P. (1983): Fibrinogen - A Modulator of Erythrocyte Adhesion to Vascular Endothelium - J. Lab. Clin. Med.101: 911–20.
WelinL.,SvardsuddK.,WilhelmsenL.,LarssonB. andTibblinG. (1987): Analysis for Risk Factors of Stroke in a Cohort of Men Born in 1913 - New Engl. J. Med.317: 521–6.
WilhelmsenK.,SvardsuddK.,Korsan-BengstenK.,LarssonB.,WelinL.,TibblinG. (1984): Fibrinogen as a Risk Factor fo Stroke and Myocardial Infarction -N. Engl. J. Med.311: 501–5.
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Di Minno, G., Cerbone, A., Margaglione, M. et al. Fibrinogen and mechanisms of thrombosis. A difficult link. Eur J Epidemiol 8 (Suppl 1), 88–91 (1992). https://doi.org/10.1007/BF00145357
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DOI: https://doi.org/10.1007/BF00145357