When histologically examined in utero at 105 hours post coitum embryos from A y/a × A y/a matings contained a mean (± SE) of 122.7 ± 6.5 nuclei per embryo; of these, 30.2 ± 2.4 nuclei were in the inner cell mass (ICM) and 92.5 ± 4.8 nuclei were within trophoblast cells. Embryos from ♂ A y/a × ♀ a/a matings contained a mean of 141.4 ± 10.6 nuclei per embryo of which 41.7 ± 4.5 nuclei were within the ICM and 99.7 ± 6.9 nuclei were trophoblastic. ICM cell numbers were significantly different between genotypes (P < 0.05) suggesting that homozygous A y allele expression selectively interferes with ICM versus trophoblast cell differentiation during preimplantation development.
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Cizadlo, G.R., Granholm, N.H. In vivo development of the lethal yellow (Ay/Ay) mouse embryo at 105 hours post coitum. Genetica 48, 89–93 (1978). https://doi.org/10.1007/BF00127504
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DOI: https://doi.org/10.1007/BF00127504