Skip to main content
SpringerLink
Log in

The sources of genetic variability in highly inbred long-term selected strains of Drosophila melanogaster

  • Published:
Genetica Aims and scope Submit manuscript

Abstract

A highly inbred, long-term selected for low fitness strain LA of Drosophila melanogaster posesses a significant mutational load and unusually high rates of spontaneous mutability as revealed by CyL/Pm method. Our results indicate that during cross of CyL/Pm to LA strains, destabilization of copia-like and mobile elements and induction of H-E hybrid dysgenesis take place. The role of these processes in causing considerable genetic variability of LA strain is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Ashburner, M., 1989. Drosophila: A laboratory handbook. Cold Spring Harbor Laboratory Press: 1331 p.

  • Belyaeva, E. Sp., Pasyukova, E. G., Gvozdev, V. A., Ilyin, Yu. V. & Kaidanov, L. Z., 1982. Transposition of mobile dispersed genes in Drosophila melanogaster and the fitness of stocks. Mol. Gen. Genet. 185: 324–328.

    Google Scholar 

  • Blackman, R. K. & Gelbart, W. M., 1989. The transposable element hobo of Drosophila melanogaster. In: Berg, D. & Howe, M. (eds). Mobile DNA. American Society for Microbiology Publications: 523–529.

  • Blackman, R. K., Grimalia, R., Koehler, M. M. D. & Gelbart, W. M., 1987. Mobilization of hobo elements residing within the decapentaplegic gene complex: suggestion of a new hybrid dysgenesis system in Drosophila melanogaster. Cell 49: 497–505.

    Google Scholar 

  • Gvozdev, V. A., Belyaeva, E. Sp., Ilyin, Y. V., Amosova, I. S. & Kaidanov, L. Z., 1981. Selection and transposition of mobile dispersed genes in Drosophila melanogaster. Cold Spring Harbor Symp. Quant. Biol. 45: 673–685.

    Google Scholar 

  • Kaidanov, L. Z., 1980. The analysis of genetic consequences of selection and inbreeding in Drosophila melanogaster. Genetica 52/53: 165–181.

    Google Scholar 

  • Kaidanov, L. Z., 1990. The rules of genetical alterations in Drosophila melanogaster inbred lines determined by selection. Arh. biol. nauka, Beograd 42: 131–148.

    Google Scholar 

  • Kaidanov, L. Z. & Ryazanova, L. A., 1987. Characteristic of the spontaneous mutation process in the chromosome 2 in high inbred lines of Drosophila melanogaster. Vestnik Leningr. Univ. 17: 84–90.

    Google Scholar 

  • Kidwell, M. G., 1986. P-M mutagenesis. In: D. B. Roberts (ed). Drosophila: A practical approach. IRL Press: 59–81.

  • Lefevre, G. Tr., 1976. A photographic representation and interpretation of the polytene chromosomes of D.melanogaster salivary glands. In: M. Ashburner, E. Novitsky (eds.). The genetic and biology of Drosophila. Vol. 1a, Academic Press: 32–64.

  • Lim, T., 1988. Intrachromosomal rearrangements mediated by hobo transposons in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 85: 9153–9157.

    Google Scholar 

  • Pasyukova, E. G., Belyaeva, E. Sp., Ilvinskaya, L. E. & Gvozdev, V. A., 1987. Transposition of mobile dispersed genes (mdg) detected in mixed Drosophila melanogaster genomes carrying combinations of chromosomal pairs originated from different stocks. Genetica (USSR) 23: 605–615.

    Google Scholar 

  • Pasyukova, E. G., Belyaeva, E. Sp., Kogan, G. L., Kaidanov, I. Z. & Gvozdev, V. A., 1986. Concerted transposition of mobile genetic elements coupled with fitness changes in Drosophila melanogaster. Mol. Biol. Evol. 3: 299–312.

    Google Scholar 

  • Stamatis, N., Monastirioti, M., Yannopoulos, G. & Louis, C., 1989. The P-M and 23.5MRF (hobo) systems of hybrid dysgenesis in Drosophila melanogaster are independent of each other. Genetics 123: 379–387.

    Google Scholar 

  • Yannopoulos, G., Stamatis, N. & Eeken, T. C. T., 1986. Differences in the cytotype and hybrid dysgenesis inducer ability of different P strains of Drosophila melanogaster. Experientia 42: 1283–1285.

    Google Scholar 

  • Yannopoulos, G., Stamatis, N., Monastirioti, M., Hatropoutos, P. & Louis, C., 1987. Hobo is responsible for induction of hybrid dysgenesis by strains of Drosophila melanogaster bearing the male recombination factor 23.5MRF. Cell 49: 487–495.

    Google Scholar 

  • Yannopoulos, G., Zacharopoulou, A. & Stamatis, N., 1982. Unstable chromosomal rearrangements associated with male recombination in Drosophila melanogaster. Mutat. Res. 96: 41–51.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Genetics and Breeding, Leningrad State University, 199034, Leningrad, USSR

    L. Z. Kaidanov, V. N. Bolshakov & P. N. Tzygvintzev

  2. Institute of Molecular Genetics, USSR Academy of Sciences, 123182, Moscow, USSR

    V. A. Gvozdev

Authors
  1. L. Z. Kaidanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. N. Bolshakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. N. Tzygvintzev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. A. Gvozdev
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kaidanov, L.Z., Bolshakov, V.N., Tzygvintzev, P.N. et al. The sources of genetic variability in highly inbred long-term selected strains of Drosophila melanogaster . Genetica 85, 73–78 (1991). https://doi.org/10.1007/BF00056108

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00056108

Keywords

Search

Navigation