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Cellular Signal-Regulated Schwann Cell Myelination and Remyelination

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Myelin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1190))

Abstract

Increasing studies have demonstrated multiple signaling molecules responsible for oligodendrocytes and Schwann cells development such as migration, differentiation, myelination, and axo-glial interaction. However, complicated roles in these events are still poorly understood. This chapter focuses on well established intracellular signaling transduction and recent topics that control myelination and are elucidated from accumulating evidences. The underlying molecular mechanisms, which involved in membrane trafficking through small GTPase Arf6 and its activator cytohesins, demonstrate the crosstalk between well established intracellular signaling transduction and a new finding signaling pathway in glial cells links to physiological phenotype and essential role in peripheral nerve system (PNS). Since Arf family proteins affect the expression levels of myelin protein zero (MPZ) and Krox20, which is a transcription factor regulatory factor in early developmental stages of Schwann cells, Arf proteins likely to be key regulator for Schwann cells development. Herein, we discuss how intracellular signaling transductions in Schwann cells associate with myelination in CNS and PNS.

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Authors and Affiliations

  1. Graduate School of Brain Science, Doshisha University, Kyotanabe-shi, Kyoto, Japan

    Tomohiro Torii

  2. Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan

    Yuki Miyamoto

  3. Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan

    Junji Yamauchi

Authors
  1. Tomohiro Torii
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  2. Yuki Miyamoto
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  3. Junji Yamauchi
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Corresponding author

Correspondence to Junji Yamauchi .

Editor information

Editors and Affiliations

  1. Diabetic Neuropathy Project, Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

    Kazunori Sango

  2. Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan

    Junji Yamauchi

  3. Department of Rehabilitation for the Movement Functions, Research Institute, National Rehabilitation Center, Tokorozawa, Saitama, Japan

    Toru Ogata

  4. Department of Neuroscience, Cell Biology, and Physiology, Boonshoft School of Medicine, Wright State University, Dayton, OH, USA

    Keiichiro Susuki

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Torii, T., Miyamoto, Y., Yamauchi, J. (2019). Cellular Signal-Regulated Schwann Cell Myelination and Remyelination. In: Sango, K., Yamauchi, J., Ogata, T., Susuki, K. (eds) Myelin. Advances in Experimental Medicine and Biology, vol 1190. Springer, Singapore. https://doi.org/10.1007/978-981-32-9636-7_1

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