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From axon–glial signalling to myelination: the integrating role of oligodendroglial Fyn kinase

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Abstract

Central nervous system myelination requires recognition and signalling processes between neuronal axons and oligodendrocytes. Complex cellular rearrangements occur in myelination-competent oligodendrocytes requiring spatio-temporal control mechanisms. Although the molecular repertoire is becoming increasingly transparent, the signalling mechanisms governing myelination initiation are only poorly understood. The non-receptor tyrosine kinase Fyn has been implicated in axon–glial signal transduction and in several cellular processes required for oligodendrocyte maturation and myelination. Here, we review oligodendroglial Fyn signalling and discuss the role of Fyn in axon–glia interaction mediating myelination.

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Abbreviations

A2RE:

hnRNP-A2 response element

Cbp:

CSK binding protein

CNS:

Central nervous system

Csk:

C-terminal Src kinase

Dcc:

Deleted in colorectal carcinoma

ECM:

Extracellular matrix

FAK:

Focal adhesion kinase

FcRγ:

γ chain of immunoglobulin Fc receptors

hnRNP:

Heterogeneous nuclear ribonucleoprotein

MAG:

Myelin-associated glycoprotein

MBP:

Myelin basic protein

OPC:

Oligodendrocyte precursor cell

PDGF:

Platelet-derived growth factor

PLP:

Proteo-lipid protein

PTP:

Receptor-like protein-tyrosine phosphatase

SH:

Src-homology domain

WAVE2:

Wiskott–Aldrich syndrome protein family member 2

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Acknowledgments

We thank Constantin Gonsior and Christine Winterstein for critical comments on the manuscript. The authors are grateful to Jacqueline Trotter and Heiko Luhmann for continuous support. E-M. K-A. would like to acknowledge support from the European Leukodystrophy Association and R.W. shows gratitude to the University of Mainz for start-up funding level 1.

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  1. Molecular Cell Biology, Department of Biology, Johannes Gutenberg University of Mainz, Bentzelweg 3, 55128, Mainz, Germany

    Eva-Maria Krämer-Albers

  2. Institute of Physiology and Pathophysiology, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55128, Mainz, Germany

    Robin White

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Correspondence to Eva-Maria Krämer-Albers or Robin White.

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Krämer-Albers, EM., White, R. From axon–glial signalling to myelination: the integrating role of oligodendroglial Fyn kinase. Cell. Mol. Life Sci. 68, 2003–2012 (2011). https://doi.org/10.1007/s00018-010-0616-z

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