Skip to main content

Abstract

Nelumbo nucifera Gaertn (2n = 16) (Nelumbonaceae), also known as the Sacred Lotus is an imperative perennial plant of aquatic habitat renowned for its prominent, beautiful, and magnificent flowers with diverse colors and owning nutritional and medicinal significance. Lotus of Asian countries are in shades of pink to pure white. Many bioactive chemical constituents mainly alkaloids, terpenoids, flavonoids, and phenolics have been identified in lotus. The medicinal principles relating to phytochemical and pharmacological activities mainly include antioxidant potential. In recent times, attention has mounted significantly in finding antioxidants from natural sources for utilization in foods or medicines. Because of the appraisal of antioxidant activity of plants as medicine, Nelumbo nucifera Gaertn which is very significant against damage triggered by the free radicals within a cell and reactive oxygen species (ROS) in a living being was explored for the antioxidant prospective of flowers, receptacles, leaves, seeds, and rhizomes. This chapter aims at understanding the antioxidant properties of different plant parts (leaves, flowers, receptacle, seeds, and rhizomes) of Nelumbo nucifera Gaertn, phytochemistry of its various bioactive compounds over and above alkaloids, flavonoids, glycosides, triterpenoids, etc., and the benefits derived from these phytoconstituents.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Anonymous (1966) The wealth of India. A dictionary of Indian raw materials and industrial products. Council of Scientific Industrial Research, New Delhi

    Google Scholar 

  • Anonymous (1982) Pharmacognosy of indigenous drugs vol. 2. Central Council for Research in Ayurveda and Siddha, New Delhi, p 806

    Google Scholar 

  • Anonymous (1992) The wealth of India. A dictionary of Indian raw materials and industrial products, vol III, 2nd edn. Council of Scientific Industrial Research, New Delhi, pp 336–354

    Google Scholar 

  • Arjun P, Saranya Sivan PS, Mohana Priya S, Krishnamoorthy M, Balasubramanian K (2012) Phytochemical analysis and anticancer activity of Nelumbo nucifera Gaertn extracts. J Acad Indus Res 1(2):81–85

    Google Scholar 

  • Bera S, Bhattacharya S, Pandey JN, Biswas M (2011) Thin layer chromatographic profiling and evaluation of analgesic activity of Nelumbo nucifera leaf extracts in Swiss mice. J Adv Pharm Educ Res (JAPER) 1(6):259–265

    Google Scholar 

  • Bi Y, Yang G, Li H, Zhang G, Guo Z (2006) Characterization of the chemical composition of Lotus plumele oil. J Agric and Food Chem 54(20):7672–7677. https://doi.org/10.1021/jf0607011

    Article  CAS  Google Scholar 

  • Brindha B, Arthi D (2010a) Antimicrobial activity of white and pink Nelumbo nucifera Gaertn flowers. Asian J Pharm Health Care (AJPRHC) 2(2):147–155

    Google Scholar 

  • Brindha D, Arthi D (2010b) Antiplatelet activity of white and pink Nelumbo nucifera Gaertn Flowers. Br J of Pharmaceut Sci 46(3):579–583. https://doi.org/10.1590/S1984-82502010000300023

    Article  Google Scholar 

  • Chakravarthi PV, Gopakumar N (2009) Evaluation of analgesic activity of Lotus seeds (Nelumbo nucifera) in albino rats. Vet World 2(9):355–357

    Google Scholar 

  • Chatterjee A, Pakrashi SC (1991) The treatise on Indian medicinal plants, vol I, 1st edn. Publication and Information Directorate, New Delhi, pp 94–96

    Google Scholar 

  • Chauhan A, Agarwal M (2009) Pharmacological evaluation for the antifertility effect of the ethanolic seed extract of Nelumbo nucifera (Sacred Lotus). Pharmacology online 2(1):636–643

    Google Scholar 

  • Chen Y, Fan GR, Wu HL, Wu YT, Mitchell A (2007) Separation, identification and rapid determination of liensine, isoliensinine and neferine from embryo of the seed of Nelumbo nucifera Gaertn. by liquid chromatography coupled to diode array detector and tandem mass spectrometry. J Pharm Biomed Anal 43(1):99–104

    Article  PubMed  CAS  Google Scholar 

  • Chen S, Wu B, Fang J, Liu Y, Zhang H, Fang L, Le G, Li S (2012) Analysis of flavonoids from lotus (Nelumbo nucifera) leaves using high performance liquid chromatography/photodiode array detector tandem electrospray ionization mass spectrometry and an extraction method optimized by orthogonal design. J Chromatogr A 1227:145–153

    Article  PubMed  CAS  Google Scholar 

  • Chen S, Xiang Y, Deng J, Liu YL, Li SH (2013) Simultaneous analysis of anthocyanin and non- anthocyanin flavonoid in various tissues of different lotus (Nelumbo) cultivars by HPLC-DAD-ESI-MSn. PLoS One 8(4):1–13

    CAS  Google Scholar 

  • Cho EJ, Yokozawa T, Rhyu DY, Kim SC, Shibahara N, Park JC (2003) Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1, 1-diphenyl-2-picrylhydrazyl radical. Phytomedicine 10:544–551

    Article  PubMed  CAS  Google Scholar 

  • Choe JH, Jang A, Lee ES, Choi JH, Choi YS, Han DJ, Kim HY, Lee MA, Shim SY, Kim CJ (2011) Oxidative and color stability of cooked ground pork containing lotus leaf (Nelumbo Nucifera) and Barley Leaf (Hordeum Vulgare) powder during refrigerated storage. Meat Sci 87:12–18. https://doi.org/10.1016/j.meatsci.2010.08.011

    Article  PubMed  Google Scholar 

  • Choi YS, Choi JH, Kim HY, Kim HW, Lee MA, Chung HJ, Lee SK, Kim CJ (2011) Effect of lotus (Nelumbo nucifera) leaf powder on the quality characteristics of chicken patties in refrigerated storage. Korean J Food Sci Anim Resour 31(1):9–18

    Article  Google Scholar 

  • Chopra RN (1958) Indigenous drugs of India, 2nd edn. U N Dhur and Sons Pvt., Calcutta, p 679

    Google Scholar 

  • Chopra RN, Nayara SL, Chopra IC (1956) Glossary of Indian medicinal plants. Council of Scientific and Industrial Research, New Delhi, p 174

    Google Scholar 

  • Chu P, Chen HH, Zhou YL, Li Y, Ding Y, Jiang LW, Tsang EWT, Wu KQ, Huang SZ (2012) Proteomic and functional analyses of Nelumbo nucifera annexins involved in seed thermotolerance and germination vigor. Planta 235(6):1271–1288

    Article  PubMed  CAS  Google Scholar 

  • Das S, Ray B, Ghosal PK (1992) Structural studies of a polysaccharide from the seeds of Nelumbo nucifera. Carbohydr Res 224:331–335

    Article  CAS  Google Scholar 

  • Deepa PK, Usha PTA, Chandrasekharan Nair AM, Prasannakumari KT (2009) Antipyretic activity of seeds from red and white type of lotus (Nelumbo nucifera) in Albino rat. Vet World 2(6):213–214

    Google Scholar 

  • Deng J, Chen S, Yin XJ, Wang K, Liu YL, Li SH, Yang PF (2013) Systematic qualitative and quantitative assessment of anthocyanins, flavones and flavonols in the petals of 108 lotus (Nelumbo nucifera) cultivars. Food Chem 139(1–4):307–312

    Article  PubMed  CAS  Google Scholar 

  • Devkota SR, Paudel KR, Sharma K et al (2015) Investigation of antioxidant and anti-inflammatory activity of roots of Rumex nepalensis. World J Pharm Pharm Sci (WJPPS) 4(3):582–594

    Google Scholar 

  • Dey TB, Chakraborty S, Jain KK, Sharma A, Kuhad RC (2016) Antioxidant phenolics and their microbial production by submerged and solid state fermentation process: a review. Trends Food Sci Technol 53:60–74

    Article  CAS  Google Scholar 

  • Du H, You JS, Zhao X, Park JY, Kim SH, Chang KJ (2010) Antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet. J Biomed Sci 17(1):S42–S47. https://doi.org/10.1186/1423-0127-17-S1-S39

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Duan Y, Zhang H, Xu F, Xie B, Yang X, Wang Y, Yan Y (2004) Inhibition effect of procyanidins from lotus seedpod on mouse B16 melanoma in vivo and in vitro. Food Chem 122:84–91

    Article  CAS  Google Scholar 

  • Duan Y, Zhang H, Xie B, Yan Y, Li J, Xu F, Qin Y (2010) Whole body radioprotective activity of an acetone-water extract from the seedpod of Nelumbo nucifera Gaertn. Seedpod Food Chem Toxicol 48(12):3374–3338

    Article  PubMed  CAS  Google Scholar 

  • Duke JA, Bogenschutz-Godwin MJ, duCellier J, Duke AK (2002) Handbook of medicinal herbs. CRC Press, Boca Raton, p 595

    Book  Google Scholar 

  • Durairaj B, Dorai A (2014) Free radical scavenging potential of Nelumbo nucifera Gaertn flowers (white and pink). Int J Nat Sci Res 2(8):133–146

    Google Scholar 

  • Feng CY, Li SS, Yin DD, Zhang HJ, Tian DK, Wu Q, Wang LJ, Su S, Wang LS (2016) Rapid determination of flavonoids in plumules of sacred lotus cultivars and assessment if their antioxidant activities. Ind Crop Prod 87:96–104

    Article  CAS  Google Scholar 

  • Follett J, Douglas J (2003) Lotus root: production in Asia and potential for New Zealand. In Combined proceedings international plant propagators society, vol 53, pp 79–83

    Google Scholar 

  • Furukawa H (1966) Studies on the alkaloids of Nelumbo nucifera Gaertn. NMR spectra of Liensinine type alkaloids. J Pharm Soc Jpn 86(10):883–886

    Article  CAS  Google Scholar 

  • Furukawa H, Yang TH, Lin TJ (1965) On the alkaloids of Nelumbo nucifera Gaertn. XI. Alkaloids of loti embryo. 4. Structure of lotusine, a new water soluble quaternary base. J Pharm Soc Jpn 85(5):472–475

    Article  CAS  Google Scholar 

  • Gong YS, Liu LG, Xie BJ, Liao YC, Yang EL, Sun ZD (2008) Ameliorative effects of lotus seedpod proanthocyanidins on cognitive deficits and oxidative damage in senescence-accelerated mice. Behav Brain Res 194:100–107

    Article  PubMed  CAS  Google Scholar 

  • Goo HR, Choi JS, Na DH (2009) Simultaneous determination of quercetin and its glycosides from the leaves of Nelumbo nucifera by reversed-phase high-performance liquid chromatography. Arch Pharm Res 32(2):201–206. https://doi.org/10.1007/s12272-009-1136-y

    Article  PubMed  CAS  Google Scholar 

  • Guo H (2009) Cultivation of lotus (Nelumbo nucifera Gaertn. ssp. nucifera) and its utilization in China. Genet Resour Crop Evol 56(3):323–330

    Article  Google Scholar 

  • Gutteridge JM, Halliwell B (2000) Free radicals and antioxidants in the year 2000-A historical look to the future. Ann N Y Acad Sci 899:136–147

    Article  PubMed  CAS  Google Scholar 

  • Ham YK, Hwang KE, Song DH, Kim YJ, Shin DJ, Kim KI, Lee HJ, Kim NR, Kim CJ (2017) Lotus (Nelumbo nucifera) rhizome as an antioxidant dietary Fiber in cooked sausage: effects on physicochemical and sensory characteristics. Korean J Food Sci Anim Resour 37:219–227. https://doi.org/10.5851/kosfa.2017.37.2.219

    Article  PubMed  PubMed Central  Google Scholar 

  • Harborne JB (1998) Phytochemical methods, 3rd edn. Chapman & Hall, London

    Google Scholar 

  • Harer WB (1985) Pharmacological and biological properties of the Egyptian lotus. J Am Res Cent Egypt (JARCE) 22:49–54

    Article  Google Scholar 

  • Horwitz W (2000) Official methods of analysis of AOAC international, 17th Ed., vol. 2. AOAC international, Maryland. Chapter 45: p5

    Google Scholar 

  • Hu SY (2005) Food plants of China. The Chinese University Press, Hong Kong, New Territories, 844 pp

    Google Scholar 

  • Hu M, Skibsted LH (2002) Antioxidative capacity of rhizome extract and rhizome knot extract of edible lotus (Nelumbo nuficera). Food Chem 76:327–333

    Google Scholar 

  • Huang B, Ban XQ, He JS, Tong J, Tian J, Wang YW (2010a) Comparative analysis of essential oil components and antioxidant activity of extracts of Nelumbo nucifera Gaertn from various areas of China. J Agric Food Chem 58(1):441–448

    Article  PubMed  CAS  Google Scholar 

  • Huang B, Ban XQ, He JS, Tong J, Tian J, Wang YW (2010b) Hepatoprotective and antioxidant activity of ethanolic extracts of edible lotus (Nelumbo nucifera Gaertn.) leaves. Food Chem 120(3):873–878

    Article  CAS  Google Scholar 

  • Huang B, He J, Ban X, Zeng H, Yao X, Wang Y (2011) Antioxidant activity of bovine and porcine meat treated with extracts from edible lotus (Nelumbo nucifera) rhizome knot and leaf. Meat Sci 87:46–53

    Article  PubMed  CAS  Google Scholar 

  • Huralikuppi JC, Christopher AB, Stephen P (1991) Antidiabetic effect of Nelumbo nucifera (Gaertn): Part I preliminary studies in rabbits. Phytother Res 5:54–58

    Article  Google Scholar 

  • Hwang D, Charchoghlyan H, Lee JS, Kim M (2015) Bioactive compounds and antioxidant activities of the Korean lotus leaf (Nelumbo nucifera) condiment: volatile and nonvolatile metabolite profiling during fermentation. Int J Food Sci Tech (IJFST) 50:1988–1995

    Article  CAS  Google Scholar 

  • Hyun AJ, Jung EK, Hae YC, Jae SC (2003) Antioxidant principles of Nelumbo nucifera stamens. Arch Pharm Res 26:279–285

    Article  Google Scholar 

  • Hyun SK, Jung YJ, Chung HY, Jung HA, Choi JS (2006) Isorhamnetin glycosides with free radical and ONOO- scavenging activities from the stamens of Nelumbo nucifera Gaertn. Arch Pharm Res 29(4):287–292

    Article  PubMed  CAS  Google Scholar 

  • Ibrahim N, Eraqy EW (1996) Protein content and amino acid composition of Nelumbo nucifera Gaertn seeds and its evaluation as hypoglycemic agent. Egypt J Pharm Sci 37:635–641

    CAS  Google Scholar 

  • Indrayan AK, Sharma SD, Kumar DN, Kumar M (2005) Determination of nutritive value and analysis of mineral elements for some medicinally valued plants from Uttaranchal. Curr Sci 89:1252–1255

    CAS  Google Scholar 

  • Jiqu X, Shuang R, Bijun X, Zhida S, Li Z, Hailei W, Ping Y, Liping H, Liegang L (2010) Procyanidins extracted from the lotus seedpod ameliorate age-related antioxidant deficit in aged rats. J Gerontol 65:236–241

    Google Scholar 

  • Jung HA, Kim JE, Chung HY, Choi JS (2003) Antioxidant principles of Nelumbo nucifera Gaertn stamens. Arch Pharm Res 26(4):279–285

    Article  PubMed  CAS  Google Scholar 

  • Jung IC, Park HS, Choi YJ, Park SS, Kim MJ, Park KS (2011) The effect of adding lotus root and leaf powder on the quality characteristics of cooked pork patties. Korean J Food Cookery Sci 27:783–791. https://doi.org/10.9724/kfcs.2011.27.6.783

    Article  Google Scholar 

  • Karadag A, Ozcelik B, Saner S (2009) Review of methods to determine antioxidant capacities. Food Anal Method 2:41–60

    Article  Google Scholar 

  • Karki R, Jung MA, Kim KJ, Kim DW (2012) Inhibitory effect of Nelumbo nucifera (Gaertn.) on the development of atopic dermatitis-like skin lesions in NC/Nga mice. Evid Based Complement Alternat Med 2012:153568

    Article  PubMed  PubMed Central  Google Scholar 

  • Karki R, Jeon ER, Kim DW (2013) Nelumbo nucifera Gaertn leaf extract inhibits neointimal hyperplasia through modulation of smooth muscle cell proliferation and migration. Nutrition 29(1):268–275

    Article  PubMed  CAS  Google Scholar 

  • Kashiwada Y, Aoshima A, Ikeshiro Y, Chen YP, Furukawa H, Itoigawa M, Fujioka T, Mihashi K, Cosentino LM, Morris SL, Lee KH (2005) Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure activity correlations with related alkaloids. Bioorg Med Chem 13(2):443–448

    Article  PubMed  CAS  Google Scholar 

  • Khare CP (2004) Indian herbal remedies: rational western therapy, ayurvedic, and other traditional usage, Botany, 1st edn. Springer, New York, pp 326–327

    Book  Google Scholar 

  • Kim J, Kang M, Cho C, Chung H, Kang C, Parvez S et al (2006) Effects of Nelumbinis semen on contractile dysfunction in ischemic and reperfused rat heart. Arch Pharm Res 29:777–785

    Article  PubMed  CAS  Google Scholar 

  • Kim T, Hj K, Sk C, Wy K, Baek H, Hy J, Kim BY, Kim D (2011) Nelumbo nucifera extracts as whitening and antiwrinkle cosmetic agent. Korean J Chem Eng 28(2):424–427

    Article  CAS  Google Scholar 

  • Kirtikar KR, Basu BD (1933) In: Blatter E, Caius JF, Mhaskar KS (eds) Indian Medicinal Plants I-IV. India, Lalit Mohan Basu, Allahabad

    Google Scholar 

  • Kirtikar KR, Basu BD (1975) Indian medicinal plants, 2nd edn. International Book Distributors, New Delhi, pp 116–120

    Google Scholar 

  • Krishnamoorthy G, Chellappan DR, Joseph J, Ravindhran D, Shabi MM, Uthrapathy S et al (2009) Antioxidant activity of Nelumbo nucifera (Gaertn) flowers in isolated perfused rat kidney. Rev Bras Farmacogn 19(1b):224–229

    Article  CAS  Google Scholar 

  • Kubo N, Hirai M, Kaneko A, Tanaka D, Kasumi K (2009) Development and characterization of simple sequence repeat (SSR) markers in the water lotus (Nelumbo nucifera). Aquat Bot 90:191–194

    Article  CAS  Google Scholar 

  • Ku-Lee H, Mun-Choi Y, Ouk-Noh D, Joo-Suh H (2005) Antioxidant effect of Korean traditional Lotus liquor (Yunyupju). Int J Food Sci Technol 40:709–787

    Article  CAS  Google Scholar 

  • Kunitomo J, Yoshikawa Y, Tanaka S, Imori Y, Isoi K, Masada Y, Hashimoto K, Inoue T (1973) Alkaloids of Nelumbo nucifera. Phytochemistry 12(3):699–701

    Article  CAS  Google Scholar 

  • Kuo YC, Lin YL, Liu CP, Tsai WJ (2005) Herpes simplex virus type 1 propagation in HeLa cells interrupted by Nelumbo nucifera. J Biomed Sci 12(6):1021–1034

    Article  PubMed  Google Scholar 

  • Kupchan SM, Dasgupta B, Fujita E, King ML (1963) The alkaloids of American lotus, Nelumbo lutea. Tetrahedron 19:227–232

    Article  CAS  Google Scholar 

  • La Cour B, Molgaard P, Yi Z (1995) Traditional Chinese medicine in treatment of hyperlipidaemia. J Ethnopharmacol 46(2):125–129

    Article  PubMed  Google Scholar 

  • Lee MW, Kim JS, Cho SM, Kim JH, Lee JS (2001) Antidiabetic constituent from the nodes of lotus rhizome (Nelumbo nucifera Gaertn). Nat Prod Sci 7:107–109

    Google Scholar 

  • Lee HK, Choi YM, Noh DO, Suh HJ (2005) Antioxidant effect of Korean traditional lotus liquor (Yunyupju). Int J Food Sci Technol 40(7):709–715

    Article  CAS  Google Scholar 

  • Lee H, Kim Y, Kim HJ et al (2012) Herbal formula, PM014, attenuates lung inflammation in a murine model of chronic obstructive pulmonary disease. Evid Based Complement Alternat Med 2012:769830

    PubMed  PubMed Central  Google Scholar 

  • Lim TK (2016) Edible medicinal and non-medicinal plants: volume 11, modified stems, roots, bulbs. Springer, Heidelberg

    Book  Google Scholar 

  • Lim SS, Jung YJ, Hyun SK, Lee YS, Choi JS (2006) Rat lens aldose reductase inhibitory constituents of Nelumbo nucifera Gaertn stamens. Phytother Res 20(10):825–830

    Article  PubMed  CAS  Google Scholar 

  • Lin JY, Wu AR, Liu CJ, Lai YS (2006) Suppressive effects of lotus plumule (Nelumbo nucifera Geartn) supplementation on LPS-induced systemic inflammation in a BALB/c mouse model. J Food Drug Anal 14(3):273–278

    CAS  Google Scholar 

  • Lin RJ, Wu MH, Ma YH, Chung LY, Chen CY, Yen CM (2014) Anthelmintic activities of Aporphine from Nelumbo nucifera Gaertn. cv. Rosa-plena against Hymenolepis nana. Int J Mol Sci 15:3624–3639

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ling ZQ, Xie BJ, Yang EL (2005) Isolation, characterization and determination of antioxidative activity of oligomeric proanthocyanidins from the seedpod of Nelumbo nucifera Gaertn. J Agric Food Chem 53(7):2441–2445

    Article  PubMed  CAS  Google Scholar 

  • Liu CP, Tsai WJ, Lin YL, Liao JF, Chen CF, Kuo YC (2004) The extracts from Nelumbo nucifera Gaertn suppress cell cycle progression, cytokine genes expression, and cell proliferation in human peripheral blood mononuclear cells. Life Sci 75(6):699–716

    Article  PubMed  CAS  Google Scholar 

  • Liu CP, Tsai WJ, Lin YL, Liao JF, Chen CF, Kuo YC (2006) Inhibition of (S)-armepavine from Nelumbo nucifera on autoimmune disease of MRL/MpJ-lpr/lpr mice. Eur J Pharmacol 531(1–3):270–279

    Article  PubMed  CAS  Google Scholar 

  • Liu S, Wang B, Li XZ, Qi LF, Liang YZ (2009) Preparative separation and purification of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera Gaertn using high-speed counter-current chromatography. J Sep Sci 32(14):2476–2481

    Article  PubMed  CAS  Google Scholar 

  • Liu C, Kao C, Wu H, Li W, Huang C, Li H, Chen C (2014) Antioxidant and anticancer aporphine alkaloids from the leaves of Nelumbo nucifera Gaertn. cv. Rosa-plena. Molecules 19(11):17829–17838

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lopez-Alarcon C, Denicola A (2013) Evaluating the antioxidant capacity of natural products: a review on chemical and cellular-based assays. Anal Chim Acta 763:1–10

    Article  PubMed  CAS  Google Scholar 

  • Mani SS, Subramanian IP, Pillai SS, Muthusamy K (2010) Evaluation of hypoglycemic activity of inorganic constituents in Nelumbo nucifera seeds on streptozotocin-induced diabetes in rats. Biol Trace Elem Res 138(1–3):226–237

    Article  PubMed  CAS  Google Scholar 

  • Mehra KL, Kanodia KC, Srivastava RN (1975) Folk uses of plants for adornment in India. Econ Bot 29(1):39–46

    Article  Google Scholar 

  • Mehta NR, Ekta P, Pragnesh P, Patani V, Shah B (2013) Nelumbo nucifera (Lotus): a review on ethanobotany, phytochemistry and pharmacology. Indian J Pharm Biol Res (IJPBR) 1(4):152–167

    Article  CAS  Google Scholar 

  • Ming R, VanBuren R, Liu Y, Yang M, Han Y, Li LT et al (2013) Genome of the long-living sacred lotus (Nelumbo nucifera Gaertn.). Genome Biol 14:R41

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Moure A, Cruz JM, Franco D, Dominguez JM, Sineiro J, Dominguez H et al (2001) Natural antioxidants from residual sources. Food Chem 72:145–171

    Article  CAS  Google Scholar 

  • Mukherjee PK, Balasubramanian R, Saha K, Saha BP, Lal P (1995a) Hypoglycemic activity of Nelumbo nucifera rhizome (methanolic extract) in streptozotocin induced diabetic rats. Phytother Res 9:522–524

    Article  Google Scholar 

  • Mukherjee PK, Giri SN, Saha K, Pal M, Saha BP (1995b) Isolation, estimation and characterization of starch from rhizomes of Nelumbo nucifera Gaertn (Fam. Nymphaeaceae). Ind Drugs 32:392–397

    CAS  Google Scholar 

  • Mukherjee PK, Balasubramanian R, Saha K, Saha BP, Lal P (1996a) A review of Nelumbo nucifera Gaertn. Anc Sci Life 15:268–276

    PubMed  PubMed Central  CAS  Google Scholar 

  • Mukherjee PK, Balasubramanian R, Saha K, Saha BP, Lal P (1996b) A review of Nelumbo nucifera Gaertn. rhizome extract. J Ethnopharmacol 54:63–67

    Article  PubMed  CAS  Google Scholar 

  • Mukherjee PK, Das J, Saha K, Pal M, Saha BP (1996c) Diuretic activity of the rhizomes of Nelumbo nucifera Gaertn (Fam. Nymphaeaceae). Phytother Res 10:424–425

    Article  Google Scholar 

  • Mukherjee PK, Saha K, Balasubramanian R, Pal M, Saha BP (1996d) Studies on psychopharmacological effects of Nelumbo nucifera Gaertn. rhizome extract. J Ethnopharmacol 54(2):63–67

    Article  PubMed  CAS  Google Scholar 

  • Mukherjee PK, Das J, Saha K, Giri SN, Pal M, Saha BP (1996e) Antipyretic activity of Nelumbo nucifera rhizome extract. Ind J Exp Biol 34(3):275–276

    CAS  Google Scholar 

  • Mukherjee PK, Balasubramanian R, Saha K, Saha BP, Lal P (1997a) Effect of Nelumbo nucifera rhizomes extract on blood sugar level in rats. J Ethnopharmacol 58:207–213

    Article  PubMed  CAS  Google Scholar 

  • Mukherjee PK, Balasubramanian R, Saha K, Saha BP, Lal P (1997b) A review of Nelumbo nucifera. Planta Med 63:367–369

    Article  PubMed  CAS  Google Scholar 

  • Mukherjee PK, Saha K, Das J, Pal M, Saha BP (1997c) Studies on the anti-inflammatory activity of rhizomes of Nelumbo nucifera. Planta Med 63(4):367–369

    Google Scholar 

  • Mukherjee PK, Mukherjee D, Maji AK, Rai S, Heinrich M (2009) The sacred lotus (Nelumbo nucifera) – phytochemical and therapeutic profile. J Pharm Pharmacol 61(4):407–422

    Article  PubMed  CAS  Google Scholar 

  • Mukherjee D, Khatua TN, Venkatesh P, Saha BP, Mukherjee PK (2010a) Immunomodulatory potential of rhizome and seed extracts of Nelumbo nucifera Gaertn. J Ethnopharmacol 128:490–494

    Article  PubMed  Google Scholar 

  • Mukherjee PKPK, Balasubramanian R, Saha K, Saha BP, Lal P (2010b) A review of Nelumbo nucifera Gaertn. J Ethnopharmacol 128:490–494

    Article  PubMed  Google Scholar 

  • Mutreja A, Agarwal M, Kushwaha S, Chauhan A (2008) Effect of Nelumbo nucifera seeds on the reproductive organs of female rats. Iran J Reprod Med 6(1):7–11

    Google Scholar 

  • Nadkarni AK (1954) Indian Materia Medica. Vol. 1 (3 rd edn). Popular Book Depot, Bombay

    Google Scholar 

  • Nagarajan S, Nair AGR, Ramkrishnan S, Subramanian SS (1966) Chemical examination of the flowers of Nelumbium speciosum willd. Curr Sci 35(7):176

    CAS  Google Scholar 

  • Nguyen Q (1999) Lotus a new crop for Australian horticulture. IHD Access Asia Newslett 2:1–5. http://www.nre.vic.gov.au/trade/asiaveg/nlaf-04c.htm

    Google Scholar 

  • Ohkoshi E, Miyazaki H, Shindo K, Watanabe H, Yoshida A, Yajima H (2007) Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice. Planta Med 73(12):1255–1259

    Article  PubMed  CAS  Google Scholar 

  • Onishi E, Yamada K, Yamada T, Kaji K, Inoue H, Seyama Y, Yamashita S (1984) Comparative effects of crude drugs on serum lipids. Chem Pharm Bull 32(2):646–650

    Article  CAS  Google Scholar 

  • Ono Y, Hattori E, Fukaya Y, Imai S, Ohizumi Y (2006) Anti-obesity effect of Nelumbo nucifera Gaertn leaves extract in mice and rats. J Ethnopharmacol 106(2):238–244

    Article  PubMed  Google Scholar 

  • Patel KK, Toppo FA, Singour PK, Chaurasiya PK, Rajak H, Pawar RS (2012) Phytochemical and pharmacological investigations on the aerial parts of Nelumbo nucifera Gaertn. For hematopoietic activity. Indian J Nat Prod Resour 3(4):512–517

    CAS  Google Scholar 

  • Phillips R, Rix M (1995) Vegetables, vol IV, 3rd edn. Macmillan Reference Books, London, pp 736–796

    Google Scholar 

  • Phonkot N, Aromdee C (2006) Determination of total flavonoids, total carotenes and antioxidant activity of 4 varieties of lotus stamens. Isan J Pharm Sci 2(2):136

    Google Scholar 

  • Phonkot N, Wangsomnuk PP, Aromdee C (2010) High-performance liquid chromatographic determination of β-carotene content in four varieties of lotus stamens. Songklanakarin J Sci Technol 32(4):373–377

    CAS  Google Scholar 

  • Qi A, Zhou D (2013) Lotus seed epicarp extract as potential antioxidant and anti-obesity additive in Chinese Cantonese sausage. Meat Sci 93:257–262

    Article  PubMed  CAS  Google Scholar 

  • Qian JQ (2002) Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives. Acta Pharmacol Sin 23(12):1086–1092

    PubMed  CAS  Google Scholar 

  • Raghunath K, Mitra R (2005) Pharmacognosy of indigenous drugs, vol 2. Central Council for Research in Ayurveda and Siddha, India, p 806

    Google Scholar 

  • Rai S, Wahile A, Mukherjee K, Saha BP, Mukherjee PK (2006) Antioxidant activity of Nelumbo nucifera (sacred lotus) seeds. J Ethnopharmacol 104(3):322–327

    Article  PubMed  Google Scholar 

  • Rakesh PD, Sekar S, Kumar KLS (2011) A comparative study on the antidiabetic effect of Nelumbo nucifera and glimepiride in streptozotocin induced diabetic rats. Int J Pharm Bio Sci 2(2):63–69

    Google Scholar 

  • Rao GMM, Pushpangadan P, Shirwaikar A (2005) Hepatoprotective activity of Nelumbo nucifera Geartn. flower an ethanopharmacological study. Acta Pharm Ceutica Turcica 47:79–88

    Google Scholar 

  • Saengkhae C, Arunnopparat W, Sungkhajorn P (2008) Antioxidant activity of Nelumbo nucifera Gaertn on oxidative stress-induced erythrocyte hemolysis in hypertensive and normotensive rats. J Physiol Sci 20(2):70–78

    Google Scholar 

  • Sayre J (2004) Native plants: propagation protocol for American lotus (Nelumbo lutea Willd). Native Plants J 15:14–17

    Article  Google Scholar 

  • Sheikh SA (2014) Ethno-medicinal uses and pharmacological activities of lotus (Nelumbo nucifera). J Med Plants Stud 2(6):42–46

    Google Scholar 

  • Shen-Miller J (2002) Sacred lotus, the long-living fruits of China Antique. Seed Sci Res 12(3):131–143

    Article  CAS  Google Scholar 

  • Shen-Miller J, Schopf JW, Harbottle G, Cao RJ, Ouyang S, Zhou KS, Southon JR, Liu GH (2002) Long-living lotus: germination and soil g-irradiation of centuries-old fruits, and cultivation, growth, and phenotypic abnormalities of offspring. Am J Bot 89:236–247

    Article  PubMed  CAS  Google Scholar 

  • Shoji N, Umeyama A, Saito N, Iuchi A, Takemoto T, Kajiwara A et al (1987) Asimilobine and liridine, serotonergic receptor antagonists from Nelumbo nucifera. Nat Prod 50:773–774

    Article  CAS  Google Scholar 

  • Shukla S, Lee JS, Park J, Hwang DJ, Park JH, Kim M (2016) Quantitative analysis of functional components from Nelumbo nucifera root-fermented broth with antioxidant and tyrosinase inhibitory effects. J Food Biochem 40:248–259

    Article  CAS  Google Scholar 

  • Sinha S, Mukherjee PK, Mukherjee K, Pal M, Mandal SC, Saha BP (2000) Evaluation of antipyretic potential of Nelumbo nucifera stalk extract. Phytother Res 14:272–274

    Article  PubMed  CAS  Google Scholar 

  • Sohn DH, Kim YC, Oh SH, Park EJ, Li X, Lee BH (2003) Hepatoprotective and free radical-scavenging effects of Nelumbo nucifera. Phytomedicine 10:165–169

    Article  PubMed  CAS  Google Scholar 

  • Sridhar KR, Bhat R (2007) Lotus – a potential nutraceutical source. J Agric Technol 3:143–155

    Google Scholar 

  • Subasini U, Thenmozhi S, Venkateswaran V, Pavani P, Diwedi S, Rajamanickam GV (2014) Phytochemical analysis and anti hyperlipidemic activity of Nelumbo nucifera in male Wistar rats. Int J Pharm Teach Pract (IJPTP) 5(1):935–940

    Google Scholar 

  • Tomita M, Watanabe Y, Furukawa H (1961) On the alkaloids of Nelumbo nucifera Gaertn. IV. Isolation of dl-armepavine. Jpn J Pharmacol Yakugaku Zasshi 81(11):1644–1647

    Article  CAS  Google Scholar 

  • Tomita M, Furukawa H, Yang TH, Lin TJ (1965) On the alkaloids of Nelumbo nucifera Gaertn Gaertn. VIII. Studies on the alkaloids of loti embryo. (1). Structure of isoliensinine, a new biscoclaurine type alkaloid. Chem Pharm Bull 13(1):39–43

    Article  CAS  Google Scholar 

  • Toyoda K (1966) Glutathione in the seed of Nelumbo nucifera. Chem Abstr 65:10959

    Google Scholar 

  • United States Department of Agriculture Agricultural Research Service (2019) Food Data Central: Food and Nutrient Database for Dietary studies with standard reference legacy release-169250, 16859. Retrieved 10-03-2020. www. fdc.nal.usda.gov

  • Ushimaru T, Kanematsu S, Katayama M, Tsuji H (2000) Antioxidative enzymes in seedlings of Nelumbo nucifera germinated under water. Physiol Plant 112:39–46

    Article  Google Scholar 

  • Vahitha Bi SM, Banumathi V, Anbu J, Anjana A, Kumar MP (2012) Aphrodisiac activity of venthamarai magarantha chooranam (stamens of Nelumbo nucifera white variety) on healthy wister albino rats. Int J Life Sci Pharma Res 2:44–50

    Google Scholar 

  • Varshney CK, Rzóska J (1976) Aquatic weeds in South East Asia, 1st edn. Springer, New Delhi, p 39

    Google Scholar 

  • Venkatesh B, Dorai A (2011) Antibacterial and antioxidant potential of white and pink Nelumbo nucifera Gaertn flowers. Int Conf Biosci Bioche Bioinform 5:213–217

    Google Scholar 

  • Wang YW (2010) Hepatoprotective and antioxidant activity of ethanolic extracts of edible lotus (Nelumbo nucifera Gaertn.) leaves. Food Chem 120:873–878

    Article  CAS  Google Scholar 

  • Wang Q, Zhang X (2005) Lotus flower cultivars in China. China Forestry Publishing House, Beijing, (ISBN:7-5038-3867-1)

    Google Scholar 

  • Wang JL, Hu XM, Yin WH, Cai HS (1991) Studies on alkaloids of Plumula Nelumbinis. Zhongguo Zhong Yao Za Zhi (J Chin Mat Med) 16(11):673–675

    CAS  Google Scholar 

  • Williamson PS, Schneider EL (1993) Nelumbonaceae. In: Kubitzki K (ed) The families and genera of vascular plants. Springer, Berlin, pp 470–473

    Google Scholar 

  • Wong CF (1987) Origin and historical record of Nelumbo nucifera, Eds. China Institute of Botany, China lotus, Beijing, Academia Sinica, Science Publishers, pp 1–8

    Google Scholar 

  • Wu MJ, Wang L, Weng CY, Yen JH (2003) Antioxidant activity of methanol extract of the lotus leaf (Nelumbo nucifera Gaertn). Am J Chin Med 31:687–698

    Article  PubMed  Google Scholar 

  • Wu SH, Sun CR, Cao XJ, Zhou H, Hong Z, Pan YJ (2004) Preparative counter-current chromatography isolation of liensinine and its analogues from embryo of the seed of Nelumbo nucifera GAERTN. Using upright coil planet centrifuge with four multilayer coils connected in series. J Chromatogr A 1041(1–2):153–162

    Article  PubMed  CAS  Google Scholar 

  • Wu YB, Zheng LJ, Yi J, Wu JG, Chen TQ, Wu JZ (2013) Quantitative and chemical fingerprint analysis for the quality evaluation of Receptaculum Nelumbinis by RP-HPLC coupled with hierarchical clustering analysis. Int J Mol Sci 14(1):1999–2010

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Xiao JH, Zhang JH, Chen HL, Feng XL, Wang JL (2005) Inhibitory effect of isoliensinine on bleomycin induced pulmonary fibrosis in mice. Planta Med 71:225–230

    Article  PubMed  CAS  Google Scholar 

  • Yang DM, Wang QS, Ke LQ, Jiang JM, Ying TJ (2007) Antioxidant activities of various extracts of lotus (Nelumbo nuficera Gaertn) rhizome. Asia Pac J Clin Nutr 16(Suppl 1):158–163

    PubMed  Google Scholar 

  • Yang RZ, Wei XL, Gao FF, Wang LS, Zhang HJ, Xu YJ, Li CH, Ge YX, Zhang JJ, Zhang J (2009) Simultaneous analysis of anthocyanins and flavonols in petals of lotus (Nelumbo) cultivars by high-performance liquid chromatography-photodiode array detection/electrospray ionization mass spectrometry. J Chromatogr A 1216:106–112

    Article  PubMed  CAS  Google Scholar 

  • Yang M, Han Y, VanBuren R, Ming R, Xu L, Han Y et al (2012) Genetic linkage maps for Asian and American lotus constructed using novel SSR markers derived from the genome of sequenced cultivar. BMC Genomics 13:653

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yen GC, Duh PD, Su HJ (2005) Antioxidant properties of lotus seed and its effect on DNA damage in human lymphocytes. Food Chem 89:379–385

    Article  CAS  Google Scholar 

  • Yen GC, Duh PD, Yeha CT, Wu CH (2006) Scavenging effects of lotus seed extracts on reactive nitrogen species. Food Chem 94(4):596–602

    Article  CAS  Google Scholar 

  • You PZ (1998) Chinese Materia Medica: chemistry, pharmacology and applications. Harwood Academic Publishers, Amsterdam, ISBN:90-5702-285

    Google Scholar 

  • You JS, Lee YJ, Kim KS, Kim SH, Chang KJ (2014) Antiobesity and hypolipidaemic effects of Nelumbo nucifera Gaertn seed ethanol extract in human pre-adipocytes and rats fed a high-fat diet. J Sci Food Agric 94(3):568–575

    Article  PubMed  CAS  Google Scholar 

  • Youn UJ, Lee JH, Lee YJ, Nam JW, Bae H, Seo EK (2010) Regulation of the 5-HT3A receptor-mediated current by alkyl 4-hydroxybenzoates isolated from the seeds of Nelumbo nucifera. Chem Biodivers 7(9):2296–2302

    Article  PubMed  CAS  Google Scholar 

  • Yu J, Hu WS (1997) Effects of neferine on platelet aggregation in rabbits. Acta Pharm Sin 32:1–4

    CAS  Google Scholar 

  • Zhang XH, Zhang B, Gong PL, Zeng FD (2004) Protective effect of procyanidins from the seedpod of the lotus on myocardial ischemia and its mechanisms. Yao Xue Xue Bao 39:747–750

    PubMed  CAS  Google Scholar 

  • Zhang L, Tu ZC, Wang H et al (2015) Response surface optimization and physicochemical properties of polysaccharides from Nelumbo nucifera leaves. Int J Biol Macromol 74:103–110. https://doi.org/10.1016/j.ijbiomac.2014.11.020

    Article  PubMed  CAS  Google Scholar 

  • Zheng LJ, Wu YB, Wu JG, Tan CJ, Yi J, Chen TQ, Wu JZ (2012) Antioxidant activity of lotus (Nelumbo nucifera Gaertn.) receptacles of eleven cultivars grown in China. J Med Plants Res 6(10):1902–1911. https://doi.org/10.5897/JMPR11.1373

    Article  Google Scholar 

  • Zhou T, Luo D, Li X, Luo Y (2009) Hypoglycemic and hypolipidemic effects of flavonoids from lotus (Nelumbo nucifera Gaertn) leaf in diabetic mice. J Med Plant Res 3(4):290–300

    Google Scholar 

  • Zhu M, Liu T, Zhang C, Guo M (2017) Flavonoids of Lotus (Nelumbo nucifera) Seed embryos and their antioxidant potential. J Food Sci 82(8):1834–1841. https://doi.org/10.1111/1750-3841.13784

    Article  PubMed  CAS  Google Scholar 

  • Zoecklin BW, Fugelsang KC, Gump BH, Nury FS (1995) Wine analysis and production. Chapman and Hall, New York, p 621

    Book  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Pandita, A., Pandita, D. (2020). Lotus (Nelumbo nucifera Gaertn). In: Nayik, G.A., Gull, A. (eds) Antioxidants in Vegetables and Nuts - Properties and Health Benefits. Springer, Singapore. https://doi.org/10.1007/978-981-15-7470-2_2

Download citation

Publish with us

Policies and ethics