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Non-coding RNAs and Autophagy

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Autophagy: Biology and Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1206))

Abstract

Autophagy is an important metabolic pathway of cells. Cells degrade harmful intracellular components with the aid of autophagy to maintain a healthy state. In recent decades, the study of non-coding RNA in the regulation of autophagy has been a hot area. Mounting evidence indicates that many ncRNAs are involved in the dynamic process of autophagy, and further studies were undertaken to dissect the detailed cellular and molecular mechanisms underlying this process. In this chapter, we mainly summarized the regulation of different non-coding RNAs in autophagy as well as the detailed mechanisms. Based on these findings, we also discussed the roles of non-coding RNAs in the diagnosis, treatment, and prognosis of diseases with an emphasis on their use as potential biomarkers and therapeutic targets for different diseases.

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Abbreviations

3-MA:

3-methyladenine

ADAR1:

Adenosine to inosine acting on RNA enzyme 1

ANXA2:

Annexin A2

APP:

Amyloid precursor protein

ceRNA:

Competitive endogenous RNA

circRNA:

Circular RNA

ciRNAs:

Circular intronic RNAs

CSD:

Cold shock domain

DFCP1:

Double FYVE-containing protein 1

EcircRNAs:

Exonic circRNAs

EIcircRNAs:

Exonic-intronic circRNAs

eIF4A:

Eukaryotic initiation factor 4A

gRNA:

Guide RNA

lncRNA:

Long non-coding RNA

miRNA:

Micro RNA

mRNA:

Message RNA

mt tRNAs:

Mitochondrial tRNAs

ncRNA:

Noncoding RNA

NMD:

Nonsense-mediated mRNA decay

PI3P:

Phosphatidylinositol 3-phosphate

piRNA:

Piwi-interacting

Plekhm1:

Pleckstrin homology domain-containing protein family M member 1

pre-miRNA:

Precursormicro RNA

pri-mRNA:

Primary micro RNA

PS1:

Presenilin 1

RBP:

RNA-binding protein

RES:

Ribsome entrysite

RISC:

RNA-induced silencing complex

ROS:

Reactive oxygen species

rRNA:

Ribosomal RNA

siRNA:

Small interfering

snoRNA:

Small nucleolar RNA

snRNA:

Small nuclear RNA

SR:

Serine/argine

TIPARP:

TCDD inducible poly[ADP-ribose] polymerase

tRNA:

Transfer RNA

ULK:

Unc-51-like kinase

UTR:

Untranslation region

Vps:

Vesicular protein sorting

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Author information

Authors and Affiliations

  1. Department of Pharmacology, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China

    Honghong Yao, Bing Han, Yuan Zhang, Ling Shen & Rongrong Huang

Authors
  1. Honghong Yao
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  2. Bing Han
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  3. Yuan Zhang
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  4. Ling Shen
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  5. Rongrong Huang
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Corresponding author

Correspondence to Honghong Yao .

Editor information

Editors and Affiliations

  1. Jiangsu Key Laboratory of Neuropsychiatric Diseases, Department of Pharmacology and Laboratory of Aging and Nervous Diseases, College of Pharmaceutical Sciences of Soochow University, Suzhou, China

    Zheng-Hong Qin

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Yao, H., Han, B., Zhang, Y., Shen, L., Huang, R. (2019). Non-coding RNAs and Autophagy. In: Qin, ZH. (eds) Autophagy: Biology and Diseases. Advances in Experimental Medicine and Biology, vol 1206. Springer, Singapore. https://doi.org/10.1007/978-981-15-0602-4_10

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